DegronMD

Uniprot ID: Q7RTP6

Source protein: [F-actin]-monooxygenase MICAL3

Source gene: MICAL3

Class: DEG_APCC_KENBOX_2

Location: 1562:1566

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5835

ASA_SCORE: 95.44

COIL: 0.8902

CONS_SCORE: 0.4057

DSS_SCORE: 0.6869

HELIX: 0.0828

FCONS_SCORE: 0.9984

RIG_SCORE: 0.6399

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1559L	TCGA-CG-5733	STAD	TCGA	AKENG	DEG_APCC_KENBOX_2	0.25
p.P1559L	DO38551	STAD	ICGC	AKENG	DEG_APCC_KENBOX_2	0.25
p.E1572K	TCGA-EE-A20C	SKCM	TCGA	AKENG	DEG_APCC_KENBOX_2	0.1667
p.E1572K	DO222775	MELA	ICGC	AKENG	DEG_APCC_KENBOX_2	0.1667
p.E1572K	DO47665	SKCM	ICGC	AKENG	DEG_APCC_KENBOX_2	0.1667
p.P1559Q	TCGA-FS-A1ZQ	SKCM	TCGA	AKENG	DEG_APCC_KENBOX_2	0.25
p.P1559Q	DO37442	SKCM	ICGC	AKENG	DEG_APCC_KENBOX_2	0.25
p.E1554K	TCGA-SY-A9G5	BLCA	TCGA	AKENG	DEG_APCC_KENBOX_2	0.1111
p.E1554K	DO51906	BLCA	ICGC	AKENG	DEG_APCC_KENBOX_2	0.1111
p.G1566E	DO227987	COCA	ICGC	AKENG	DEG_APCC_KENBOX_2	0.6087
p.Q1576L	DO228934	LICA	ICGC	AKENG	DEG_APCC_KENBOX_2	0.0556
p.T1574M	DO228983	LICA	ICGC	AKENG	DEG_APCC_KENBOX_2	0.5556
p.H1558P	DO229144	THCA	ICGC	AKENG	DEG_APCC_KENBOX_2	0.2222
p.H1558P	ACH-000970	Colon/Colorectal Cancer	CCLE	AKENG	DEG_APCC_KENBOX_2	0.2222
p.G1573R	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKENG	DEG_APCC_KENBOX_2	0.1389
p.R1567G	ACH-000994	Endometrial/Uterine Cancer	CCLE	AKENG	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	DEG_APCC_KENBOX_2	1214:1218	AKENG	APC,CDC20,FZR1	0.7615	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_APCC_KENBOX_2	1562:1566	AKENG	APC,CDC20,FZR1	0.5835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons