DegronMD

Uniprot ID: P19174

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Source gene: PLCG1

Class: DEG_APCC_KENBOX_2

Location: 1214:1218

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7615

ASA_SCORE: 96.16

COIL: 0.8652

CONS_SCORE: 0.2148

DSS_SCORE: 0.2572

HELIX: 0.064

FCONS_SCORE: 0.7045

RIG_SCORE: 0.725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1221R	TCGA-DD-AADO	LIHC	TCGA	AKENG	DEG_APCC_KENBOX_2	0.6944
p.F1212L	DO224977	BRCA	ICGC	AKENG	DEG_APCC_KENBOX_2	0.2778
p.G1225V	DO229027	LICA	ICGC	AKENG	DEG_APCC_KENBOX_2	0.1389
p.N1218K	DO229042	LICA	ICGC	AKENG	DEG_APCC_KENBOX_2	0.6918
p.L1220R	DO52241	LIHC	ICGC	AKENG	DEG_APCC_KENBOX_2	0.2778
p.I1207F	SIDM00820	Kidney Carcinoma	GDSC	AKENG	DEG_APCC_KENBOX_2	0.1389
p.I1207F	RCC-ER	kidney	COSMIC	AKENG	DEG_APCC_KENBOX_2	0.1389
p.T1227M	SIDM00839	Colorectal Carcinoma	GDSC	AKENG	DEG_APCC_KENBOX_2	0.5278
p.T1227M	ACH-000950	Colon/Colorectal Cancer	CCLE	AKENG	DEG_APCC_KENBOX_2	0.5278
p.T1227M	LoVo	large_intestine	COSMIC	AKENG	DEG_APCC_KENBOX_2	0.5278
p.I1207M	ACH-000975	Lung Cancer	CCLE	AKENG	DEG_APCC_KENBOX_2	0.1389
p.L1221F	ACH-001456	Colon/Colorectal Cancer	CCLE	AKENG	DEG_APCC_KENBOX_2	0.6944
p.T1226M	LoVo	large_intestine	COSMIC	AKENG	DEG_APCC_KENBOX_2	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	DEG_APCC_KENBOX_2	1214:1218	AKENG	APC,CDC20,FZR1	0.7615	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_APCC_KENBOX_2	1562:1566	AKENG	APC,CDC20,FZR1	0.5835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons