DegronMD - Q9H7N4(SCAF1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R626W	TCGA-2Z-A9JS	KIRP	TCGA	PATSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1944
p.R626W	DO219686	KIRP	ICGC	PATSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1944
p.P241L	TCGA-A5-A2K3	UCEC	TCGA	DEAYSPPP	CBL_PTK	235:242	Mutation altering degron motif	0.6471
p.P241L	DO43899	UCEC	ICGC	DEAYSPPP	CBL_PTK	235:242	Mutation altering degron motif	0.6471
p.D226N	TCGA-AP-A0LM	UCEC	TCGA	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.0833
p.D226N	DO43306	UCEC	ICGC	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.0833
p.S856T	TCGA-CK-4951	COAD	TCGA	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation blocking phosphorylation signal	0.5833
p.S856T	DO10582	COAD	ICGC	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation blocking phosphorylation signal	0.5833
p.P230A	TCGA-D8-A1JK	BRCA	TCGA	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.1944
p.P230A	DO3880	BRCA	ICGC	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.1944
p.G767R	TCGA-EB-A42Z	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.1389
p.G767R	DO37414	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.1389
p.Y228C	TCGA-EM-A3O3	THCA	TCGA	DEAYSPPP	CBL_PTK	235:242	Mutation blocking phosphorylation signal	0.5833
p.Y228C	DO48109	THCA	ICGC	DEAYSPPP	CBL_PTK	235:242	Mutation blocking phosphorylation signal	0.5833
p.R752H	TCGA-EY-A215	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.2222
p.R752H	DO42665	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.2222
p.R752H	SIDM01273	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.2222
p.R764W	TCGA-EY-A549	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.2222
p.R764W	DO48174	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.2222
p.E1038K	TCGA-FY-A3NM	THCA	TCGA	PATTT	DEG_SPOP_SBC_1	1042:1046	Mutation rewiring degron network	0.2222
p.E1038K	DO38954	THCA	ICGC	PATTT	DEG_SPOP_SBC_1	1042:1046	Mutation rewiring degron network	0.2222
p.R770Q	TCGA-G2-A2EF	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.0556
p.R770Q	DO726	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.0556
p.R751W	TCGA-GF-A6C9	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.1944
p.R751W	DO232761	PBCA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.1944
p.R751W	DO51254	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.1944
p.T848S	TCGA-RD-A8NB	STAD	TCGA	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation altering degron motif	0.6005
p.T848S	DO228246	BRCA	ICGC	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation altering degron motif	0.6005
p.T848S	DO50142	STAD	ICGC	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation altering degron motif	0.6005
p.E1037K	TCGA-VS-A94Z	CESC	TCGA	PATTT	DEG_SPOP_SBC_1	1042:1046	Mutation rewiring degron network	0.1944
p.E1037K	DO51634	CESC	ICGC	PATTT	DEG_SPOP_SBC_1	1042:1046	Mutation rewiring degron network	0.1944
p.S761C	TCGA-ZJ-AAXT	CESC	TCGA	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.3056
p.S761C	DO219758	CESC	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.3056
p.E245Q	DO48454	BLCA	ICGC	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.25
p.D235Y	DO871	BOCA	ICGC	DEAYSPPP	CBL_PTK	235:242	Mutation altering degron motif	0.7325
p.A757T	DO225124	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation altering degron motif	0.6028
p.A757T	DO233067	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation altering degron motif	0.6028
p.A757T	DO228138	PBCA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation altering degron motif	0.6028
p.Y238H	DO222576	COCA	ICGC	DEAYSPPP	CBL_PTK	235:242	Mutation altering degron motif	0.834
p.T420P	DO229010	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	419:424	Mutation altering degron motif	0.7031
p.T420P	DO229013	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	419:424	Mutation altering degron motif	0.7031
p.T420P	DO229016	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	419:424	Mutation altering degron motif	0.7031
p.T420P	DO229003	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	419:424	Mutation altering degron motif	0.7031
p.T420P	DO229005	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	419:424	Mutation altering degron motif	0.7031
p.T428K	DO229005	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	419:424	Mutation rewiring degron network	0.2222
p.D229H	DO50316	ESAD	ICGC	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.1667
p.S196P	DO223089	ESCA	ICGC	PSSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1944
p.S758A	DO228542	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation altering degron motif	0.7588
p.S758A	DO233888	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation altering degron motif	0.7588
p.A757S	DO233884	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation altering degron motif	0.6477
p.A757S	DO229009	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation altering degron motif	0.6477
p.P244L	DO233855	GACA	ICGC	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.2778
p.S747I	DO229026	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation blocking phosphorylation signal	0.5278
p.V837M	DO50970	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation rewiring degron network	0.1111
p.S614C	DO23204	LINC	ICGC	PATSS	DEG_SPOP_SBC_1	617:621	Mutation blocking phosphorylation signal	0.6944
p.P230L	DO220879	MELA	ICGC	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.1944
p.S761F	DO220911	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.3056
p.S761F	DO222632	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.3056
p.S763F	DO220913	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.25
p.E442K	DO46384	OV	ICGC	LSLHAE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.1944
p.S759F	DO35242	PACA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation altering degron motif	0.7982
p.S759F	DO218900	SKCA	ICGC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation altering degron motif	0.7982
p.S759F	SIDM01175	Other Sarcomas	GDSC	AASSS	DEG_SPOP_SBC_1	756:760	Mutation altering degron motif	0.7982
p.A417T	DO51478	PACA	ICGC	PTPAAS	DEG_SCF_FBW7_1	419:424	Mutation rewiring degron network	0.2778
p.A1054T	DO232761	PBCA	ICGC	PATTT	DEG_SPOP_SBC_1	1042:1046	Mutation rewiring degron network	0.1111
p.S614P	DO219881	SKCA	ICGC	PATSS	DEG_SPOP_SBC_1	617:621	Mutation blocking phosphorylation signal	0.6944
p.S448F	DO218855	SKCA	ICGC	LSLHAE	LIG_APCC_ABBA_1	447:452	Mutation altering degron motif	0.7982
p.S191P	DO229144	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.0556
p.S191P	DO229151	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.0556
p.S191P	DO229092	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.0556
p.P206T	DO229208	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.3056
p.E1037V	DO229218	THCA	ICGC	PATTT	DEG_SPOP_SBC_1	1042:1046	Mutation rewiring degron network	0.1944
p.T426S	DO229242	THCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	419:424	Mutation rewiring degron network	0.2778
p.A1043T	DO229242	THCA	ICGC	PATTT	DEG_SPOP_SBC_1	1042:1046	Mutation altering degron motif	0.6028
p.T848A	DO230453	UTCA	ICGC	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation altering degron motif	0.7139
p.A838V	SIDM02041	Colorectal Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation rewiring degron network	0.1389
p.D444G	SIDM02026	Colorectal Carcinoma	GDSC	LSLHAE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.25
p.P250H	SIDM00789	Colorectal Carcinoma	GDSC	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.1111
p.P250H	ACH-000997	Colon/Colorectal Cancer	CCLE	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.1111
p.P250H	ACH-001061	Colon/Colorectal Cancer	CCLE	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.1111
p.P250H	HCT-15	large intestine	COSMIC	DEAYSPPP	CBL_PTK	235:242	Mutation rewiring degron network	0.1111
p.P197S	SIDM00695	Melanoma	GDSC	PSSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2222
p.P197S	ACH-000322	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2222
p.P197S	ACH-002458	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2222
p.P197S	ACH-002460	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2222
p.P197S	HT-144	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2222
p.I841F	SIDM01157	Other Solid Cancers	GDSC	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation rewiring degron network	0.2222
p.I841F	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation rewiring degron network	0.2222
p.T849N	SIDM00497	Colorectal Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation altering degron motif	0.8166
p.T849N	ACH-000683	Colon/Colorectal Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	845:849	Mutation altering degron motif	0.8166
p.A429T	ACH-000342	Colon/Colorectal Cancer	CCLE	PTPAAS	DEG_SCF_FBW7_1	419:424	Mutation rewiring degron network	0.1944
p.F410L	ACH-000725	Breast Cancer	CCLE	PTPAAS	DEG_SCF_FBW7_1	419:424	Mutation rewiring degron network	0.0833
p.R627H	ACH-000938	Leukemia	CCLE	PATSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1667
p.S625L	ACH-000971	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.A458T	ACH-000973	Bladder Cancer	CCLE	LSLHAE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.1667
p.R751Q	ACH-000973	Bladder Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.1944
p.E1039Q	ACH-000997	Colon/Colorectal Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	1042:1046	Mutation rewiring degron network	0.25
p.E1039Q	ACH-001061	Colon/Colorectal Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	1042:1046	Mutation rewiring degron network	0.25
p.S746R	ACH-001303	Neuroblastoma	CCLE	AASSS	DEG_SPOP_SBC_1	756:760	Mutation blocking phosphorylation signal	0.5
p.E452Q	ACH-001402	Cervical Cancer	CCLE	LSLHAE	LIG_APCC_ABBA_1	447:452	Mutation altering degron motif	0.6744
p.P419H	ACH-001664	Gastric Cancer	CCLE	PTPAAS	DEG_SCF_FBW7_1	419:424	Mutation altering degron motif	0.7694
p.S453P	ACH-001735	Leukemia	CCLE	LSLHAE	LIG_APCC_ABBA_1	447:452	Mutation blocking phosphorylation signal	0.75
p.S1049T	ACH-001961	Gallbladder Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	1042:1046	Mutation rewiring degron network	0.25
p.P213L	ACH-002027	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCAF1

UniProt ID: Q9H7N4

Entrez ID: 58506

Protein name: Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCAF1 in