DegronMD

Uniprot ID: Q9H7N4

Source protein: Splicing factor, arginine/serine-rich 19

Source gene: SCAF1

Class: DEG_SCF_FBW7_1

Location: 419:424

E3 ligase: FBXW7

DEGRON score: 0.9501

ASA_SCORE: 90.3833

COIL: 0.9452

CONS_SCORE: 0.4851

DSS_SCORE: 0.7797

HELIX: 0.0268

FCONS_SCORE: 1.0028

RIG_SCORE: 0.5724

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T420P	DO229010	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	0.7031
p.T420P	DO229013	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	0.7031
p.T420P	DO229016	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	0.7031
p.T420P	DO229003	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	0.7031
p.T420P	DO229005	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	0.7031
p.T428K	DO229005	COCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	0.2222
p.A417T	DO51478	PACA	ICGC	PTPAAS	DEG_SCF_FBW7_1	0.2778
p.T426S	DO229242	THCA	ICGC	PTPAAS	DEG_SCF_FBW7_1	0.2778
p.A429T	ACH-000342	Colon/Colorectal Cancer	CCLE	PTPAAS	DEG_SCF_FBW7_1	0.1944
p.F410L	ACH-000725	Breast Cancer	CCLE	PTPAAS	DEG_SCF_FBW7_1	0.0833
p.P419H	ACH-001664	Gastric Cancer	CCLE	PTPAAS	DEG_SCF_FBW7_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SCF_FBW7_1	419:424	PTPAAS	FBXW7	0.9501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons