DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DEAYSPPP
Uniprot ID:
Q9H7N4
Source protein:
Splicing factor, arginine/serine-rich 19
Source gene:
SCAF1
Class:
CBL_PTK
Location:
235:242
E3 ligase:
CBL
DEGRON score:
0.9921
ASA_SCORE:
99.5875
COIL:
0.9253
CONS_SCORE:
0.4266
DSS_SCORE:
0.8156
HELIX:
0.0629
FCONS_SCORE:
1.0153
RIG_SCORE:
0.5891
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P241L
TCGA-A5-A2K3
UCEC
TCGA
DEAYSPPP
CBL_PTK
0.6471
p.P241L
DO43899
UCEC
ICGC
DEAYSPPP
CBL_PTK
0.6471
p.D226N
TCGA-AP-A0LM
UCEC
TCGA
DEAYSPPP
CBL_PTK
0.0833
p.D226N
DO43306
UCEC
ICGC
DEAYSPPP
CBL_PTK
0.0833
p.P230A
TCGA-D8-A1JK
BRCA
TCGA
DEAYSPPP
CBL_PTK
0.1944
p.P230A
DO3880
BRCA
ICGC
DEAYSPPP
CBL_PTK
0.1944
p.Y228C
TCGA-EM-A3O3
THCA
TCGA
DEAYSPPP
CBL_PTK
0.5833
p.Y228C
DO48109
THCA
ICGC
DEAYSPPP
CBL_PTK
0.5833
p.E245Q
DO48454
BLCA
ICGC
DEAYSPPP
CBL_PTK
0.25
p.D235Y
DO871
BOCA
ICGC
DEAYSPPP
CBL_PTK
0.7325
p.Y238H
DO222576
COCA
ICGC
DEAYSPPP
CBL_PTK
0.834
p.D229H
DO50316
ESAD
ICGC
DEAYSPPP
CBL_PTK
0.1667
p.P244L
DO233855
GACA
ICGC
DEAYSPPP
CBL_PTK
0.2778
p.P230L
DO220879
MELA
ICGC
DEAYSPPP
CBL_PTK
0.1944
p.P250H
SIDM00789
Colorectal Carcinoma
GDSC
DEAYSPPP
CBL_PTK
0.1111
p.P250H
ACH-000997
Colon/Colorectal Cancer
CCLE
DEAYSPPP
CBL_PTK
0.1111
p.P250H
ACH-001061
Colon/Colorectal Cancer
CCLE
DEAYSPPP
CBL_PTK
0.1111
p.P250H
HCT-15
large_intestine
COSMIC
DEAYSPPP
CBL_PTK
0.1111
Drug responses associated with SCAF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DEAYSPPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H7N4
Splicing factor, arginine/serine-rich 19
CBL_PTK
235:242
DEAYSPPP
CBL
0.9921
More...
