DegronMD

Degron: DEAYSPPP

Uniprot ID: Q9H7N4

Source protein: Splicing factor, arginine/serine-rich 19

Source gene: SCAF1

Class: CBL_PTK

Location: 235:242

E3 ligase: CBL

DEGRON score: 0.9921

ASA_SCORE: 99.5875

COIL: 0.9253

CONS_SCORE: 0.4266

DSS_SCORE: 0.8156

HELIX: 0.0629

FCONS_SCORE: 1.0153

RIG_SCORE: 0.5891

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y238H	DO222576	COCA	ICGC	DEAYSPPP	CBL_PTK	0.834
p.D235Y	DO871	BOCA	ICGC	DEAYSPPP	CBL_PTK	0.7325
p.P241L	TCGA-A5-A2K3	UCEC	TCGA	DEAYSPPP	CBL_PTK	0.6471
p.P241L	DO43899	UCEC	ICGC	DEAYSPPP	CBL_PTK	0.6471
p.Y228C	TCGA-EM-A3O3	THCA	TCGA	DEAYSPPP	CBL_PTK	0.5833
p.Y228C	DO48109	THCA	ICGC	DEAYSPPP	CBL_PTK	0.5833
p.P244L	DO233855	GACA	ICGC	DEAYSPPP	CBL_PTK	0.2778
p.E245Q	DO48454	BLCA	ICGC	DEAYSPPP	CBL_PTK	0.25
p.P230A	TCGA-D8-A1JK	BRCA	TCGA	DEAYSPPP	CBL_PTK	0.1944
p.P230A	DO3880	BRCA	ICGC	DEAYSPPP	CBL_PTK	0.1944
p.P230L	DO220879	MELA	ICGC	DEAYSPPP	CBL_PTK	0.1944
p.D229H	DO50316	ESAD	ICGC	DEAYSPPP	CBL_PTK	0.1667
p.P250H	SIDM00789	Colorectal Carcinoma	GDSC	DEAYSPPP	CBL_PTK	0.1111
p.P250H	ACH-000997	Colon/Colorectal Cancer	CCLE	DEAYSPPP	CBL_PTK	0.1111
p.P250H	ACH-001061	Colon/Colorectal Cancer	CCLE	DEAYSPPP	CBL_PTK	0.1111
p.P250H	HCT-15	large_intestine	COSMIC	DEAYSPPP	CBL_PTK	0.1111
p.D226N	TCGA-AP-A0LM	UCEC	TCGA	DEAYSPPP	CBL_PTK	0.0833
p.D226N	DO43306	UCEC	ICGC	DEAYSPPP	CBL_PTK	0.0833

Showing 1 to 18 of 18 entries

Drug responses associated with SCAF1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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All proteins holding degron of DEAYSPPP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7N4	Splicing factor, arginine/serine-rich 19	CBL_PTK	235:242	DEAYSPPP	CBL	0.9921	More...

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