DegronMD

Uniprot ID: Q9H7N4

Source protein: Splicing factor, arginine/serine-rich 19

Source gene: SCAF1

Class: DEG_SPOP_SBC_1

Location: 845:849

E3 ligase: SPOP

DEGRON score: 0.9657

ASA_SCORE: 85.1

COIL: 0.9162

CONS_SCORE: 0.5136

DSS_SCORE: 0.3937

HELIX: 0.04

FCONS_SCORE: 0.9407

RIG_SCORE: 0.7033

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S856T	TCGA-CK-4951	COAD	TCGA	VSSTT	DEG_SPOP_SBC_1	0.5833
p.S856T	DO10582	COAD	ICGC	VSSTT	DEG_SPOP_SBC_1	0.5833
p.T848S	TCGA-RD-A8NB	STAD	TCGA	VSSTT	DEG_SPOP_SBC_1	0.6005
p.T848S	DO228246	BRCA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.6005
p.T848S	DO50142	STAD	ICGC	VSSTT	DEG_SPOP_SBC_1	0.6005
p.V837M	DO50970	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1111
p.T848A	DO230453	UTCA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.7139
p.A838V	SIDM02041	Colorectal Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.1389
p.I841F	SIDM01157	Other Solid Cancers	GDSC	VSSTT	DEG_SPOP_SBC_1	0.2222
p.I841F	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.2222
p.T849N	SIDM00497	Colorectal Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.8166
p.T849N	ACH-000683	Colon/Colorectal Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	0.8166

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	656:660	VSSTT	SPOP	0.9967	More...
Q15398	Disks large-associated protein 5	DEG_SPOP_SBC_1	220:224	VSSTT	SPOP	0.781	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	420:424	VSSTT	SPOP	0.9437	More...
Q8NHH9	Atlastin-2	DEG_SPOP_SBC_1	33:37	VSSTT	SPOP	0.999	More...
Q8TBY9	Cilia- and flagella-associated protein 251	DEG_SPOP_SBC_1	229:233	VSSTT	SPOP	0.9658	More...
Q8TC05	Nuclear protein MDM1	DEG_SPOP_SBC_1	373:377	VSSTT	SPOP	0.9916	More...
Q8TF66	Leucine-rich repeat-containing protein 15	DEG_SPOP_SBC_1	502:506	VSSTT	SPOP	0.584	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1165:1169	VSSTT	SPOP	0.9972	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	354:358	VSSTT	SPOP	0.9025	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	845:849	VSSTT	SPOP	0.9657	More...
A6NMB9	Fidgetin-like protein 2	DEG_SPOP_SBC_1	21:25	VSSTT	SPOP	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons