DegronMD - Q15398(DLGAP5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M724I	TCGA-39-5028	LUSC	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6507
p.M724I	TCGA-56-A4ZK	LUSC	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6507
p.M724I	DO26442	LUSC	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6507
p.M724I	DO45496	LUSC	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6507
p.E40K	TCGA-AP-A1DV	UCEC	TCGA	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1944
p.E40K	DO43186	UCEC	ICGC	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1944
p.E40K	SIDM00193	Colorectal Carcinoma	GDSC	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1944
p.E40K	ACH-000991	Colon/Colorectal Cancer	CCLE	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1944
p.E40K	SNU-81	large intestine	COSMIC	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1944
p.P727S	TCGA-AX-A1CE	UCEC	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.5641
p.P727S	DO42280	UCEC	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.5641
p.N334S	TCGA-BA-4077	HNSC	TCGA	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.25
p.N334S	DO15647	HNSC	ICGC	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.25
p.E38G	TCGA-CW-6093	KIRC	TCGA	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.25
p.E38G	DO16248	KIRC	ICGC	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.25
p.S725G	TCGA-D1-A0ZS	UCEC	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6993
p.S725G	DO43626	UCEC	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6993
p.R41Q	TCGA-D3-A3C6	SKCM	TCGA	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1667
p.R41Q	TCGA-DF-A2KU	UCEC	TCGA	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1667
p.R41Q	DO37507	SKCM	ICGC	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1667
p.R41Q	DO223286	UCEC	ICGC	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1667
p.R41Q	SIDM01588	Endometrial Carcinoma	GDSC	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1667
p.R41Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1667
p.R331K	TCGA-D8-A1JA	BRCA	TCGA	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.1667
p.R331K	DO2819	BRCA	ICGC	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.1667
p.D351N	TCGA-DK-A1AC	BLCA	TCGA	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.0833
p.D351N	DO514	BLCA	ICGC	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.0833
p.L714F	TCGA-DK-A2I4	BLCA	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.1111
p.L714F	DO465	BLCA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.1111
p.S720F	TCGA-DU-6407	LGG	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation blocking phosphorylation signal	0.7222
p.S720F	DO22295	LGG	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation blocking phosphorylation signal	0.7222
p.S222F	TCGA-EE-A29V	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.7982
p.S222F	DO38006	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.7982
p.P727H	TCGA-EE-A2M7	SKCM	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6583
p.P727H	DO37847	SKCM	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6583
p.P727H	SIDM01074	Glioblastoma	GDSC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6583
p.P727H	ACH-000102	Brain Cancer	CCLE	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6583
p.P727H	GMS-10	central nervous system	COSMIC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6583
p.P330H	TCGA-EE-A2MQ	SKCM	TCGA	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.1389
p.P330H	DO37810	SKCM	ICGC	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.1389
p.L728V	TCGA-FD-A3B6	BLCA	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.5654
p.L728V	DO458	BLCA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.5654
p.A734T	TCGA-IB-AAUQ	PAAD	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.2222
p.A734T	DO51705	PAAD	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.2222
p.E349K	TCGA-LP-A4AV	CESC	TCGA	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.1389
p.E349K	DO44275	CESC	ICGC	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.1389
p.A225S	TCGA-MA-AA3W	CESC	TCGA	VSSTT	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.3056
p.A225S	DO219719	CESC	ICGC	VSSTT	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.3056
p.T223S	TCGA-O2-A52N	LUSC	TCGA	VSSTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6005
p.T223S	DO219217	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6005
p.R723K	TCGA-XF-A8HI	BLCA	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7237
p.R723K	DO51911	BLCA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7237
p.D713H	DO1094	BRCA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.0833
p.E722D	DO1094	BRCA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.5647
p.P217T	DO223531	CLLE	ICGC	VSSTT	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.25
p.V350A	DO227987	COCA	ICGC	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.1111
p.F45L	DO233262	GACA	ICGC	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.0556
p.S721N	DO227504	LAML	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation blocking phosphorylation signal	0.75
p.E352Q	DO228900	LICA	ICGC	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.0556
p.D713E	DO229019	LICA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.0833
p.T230K	DO229038	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1667
p.R218K	DO52666	MALY	ICGC	VSSTT	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2778
p.P345S	DO222702	MELA	ICGC	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.25
p.R331T	SIDM00870	Breast Carcinoma	GDSC	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.1667
p.R331T	ACH-000725	Breast Cancer	CCLE	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.1667
p.R331T	HCC202	breast	COSMIC	LTPSYT	DEG_SCF_FBW7_1	337:342	Mutation rewiring degron network	0.1667
p.D713V	ACH-000982	Colon/Colorectal Cancer	CCLE	ERMSLPLLA	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.0833
p.I23S	ACH-001346	Head and Neck Cancer	CCLE	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.1111
p.E38D	ACH-001973	Metastasis	CCLE	QKENR	DEG_APCC_KENBOX_2	31:35	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLGAP5

UniProt ID: Q15398

Entrez ID: 9787

Protein name: Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLGAP5 in