DegronMD

Uniprot ID: Q15398

Source protein: Disks large-associated protein 5

Source gene: DLGAP5

Class: DEG_APCC_KENBOX_2

Location: 31:35

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.925

ASA_SCORE: 112.94

COIL: 0.2752

CONS_SCORE: 0.4798

DSS_SCORE: 0.6095

HELIX: 0.7154

FCONS_SCORE: 1.1792

RIG_SCORE: 0.6488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E40K	TCGA-AP-A1DV	UCEC	TCGA	QKENR	DEG_APCC_KENBOX_2	0.1944
p.E40K	DO43186	UCEC	ICGC	QKENR	DEG_APCC_KENBOX_2	0.1944
p.E40K	SIDM00193	Colorectal Carcinoma	GDSC	QKENR	DEG_APCC_KENBOX_2	0.1944
p.E40K	ACH-000991	Colon/Colorectal Cancer	CCLE	QKENR	DEG_APCC_KENBOX_2	0.1944
p.E40K	SNU-81	large_intestine	COSMIC	QKENR	DEG_APCC_KENBOX_2	0.1944
p.E38G	TCGA-CW-6093	KIRC	TCGA	QKENR	DEG_APCC_KENBOX_2	0.25
p.E38G	DO16248	KIRC	ICGC	QKENR	DEG_APCC_KENBOX_2	0.25
p.R41Q	TCGA-D3-A3C6	SKCM	TCGA	QKENR	DEG_APCC_KENBOX_2	0.1667
p.R41Q	TCGA-DF-A2KU	UCEC	TCGA	QKENR	DEG_APCC_KENBOX_2	0.1667
p.R41Q	DO37507	SKCM	ICGC	QKENR	DEG_APCC_KENBOX_2	0.1667
p.R41Q	DO223286	UCEC	ICGC	QKENR	DEG_APCC_KENBOX_2	0.1667
p.R41Q	SIDM01588	Endometrial Carcinoma	GDSC	QKENR	DEG_APCC_KENBOX_2	0.1667
p.R41Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	QKENR	DEG_APCC_KENBOX_2	0.1667
p.F45L	DO233262	GACA	ICGC	QKENR	DEG_APCC_KENBOX_2	0.0556
p.I23S	ACH-001346	Head and Neck Cancer	CCLE	QKENR	DEG_APCC_KENBOX_2	0.1111
p.E38D	ACH-001973	Metastasis	CCLE	QKENR	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15398	Disks large-associated protein 5	DEG_APCC_KENBOX_2	31:35	QKENR	APC,CDC20,FZR1	0.925	More...
Q96MM7	Heparan-sulfate 6-O-sulfotransferase 2	DEG_APCC_KENBOX_2	571:575	QKENR	APC,CDC20,FZR1	0.8874	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons