DegronMD - Q96MM7(HS6ST2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P581L	TCGA-AJ-A3BH	UCEC	TCGA	QKENR	DEG_APCC_KENBOX_2	571:575	Mutation rewiring degron network	0.1667
p.P581L	TCGA-NH-A8F8	COAD	TCGA	QKENR	DEG_APCC_KENBOX_2	571:575	Mutation rewiring degron network	0.1667
p.K562N	TCGA-GN-A265	SKCM	TCGA	QKENR	DEG_APCC_KENBOX_2	571:575	Mutation rewiring degron network	0.0833
p.H569N	SIDM00092	Ovarian Carcinoma	GDSC	QKENR	DEG_APCC_KENBOX_2	571:575	Mutation rewiring degron network	0.2778
p.H569N	ACH-000617	Ovarian Cancer	CCLE	QKENR	DEG_APCC_KENBOX_2	571:575	Mutation rewiring degron network	0.2778
p.H569N	OVCAR-4	ovary	COSMIC	QKENR	DEG_APCC_KENBOX_2	571:575	Mutation rewiring degron network	0.2778

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons