DegronMD

Uniprot ID: Q96MM7

Source protein: Heparan-sulfate 6-O-sulfotransferase 2

Source gene: HS6ST2

Class: DEG_APCC_KENBOX_2

Location: 571:575

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8874

ASA_SCORE: 115.04

COIL: 0.5354

CONS_SCORE: 0.2421

DSS_SCORE: 0.8314

HELIX: 0.4504

FCONS_SCORE: 1.0295

RIG_SCORE: 0.6135

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P581L	TCGA-AJ-A3BH	UCEC	TCGA	QKENR	DEG_APCC_KENBOX_2	0.1667
p.P581L	TCGA-NH-A8F8	COAD	TCGA	QKENR	DEG_APCC_KENBOX_2	0.1667
p.K562N	TCGA-GN-A265	SKCM	TCGA	QKENR	DEG_APCC_KENBOX_2	0.0833
p.H569N	SIDM00092	Ovarian Carcinoma	GDSC	QKENR	DEG_APCC_KENBOX_2	0.2778
p.H569N	ACH-000617	Ovarian Cancer	CCLE	QKENR	DEG_APCC_KENBOX_2	0.2778
p.H569N	OVCAR-4	ovary	COSMIC	QKENR	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15398	Disks large-associated protein 5	DEG_APCC_KENBOX_2	31:35	QKENR	APC,CDC20,FZR1	0.925	More...
Q96MM7	Heparan-sulfate 6-O-sulfotransferase 2	DEG_APCC_KENBOX_2	571:575	QKENR	APC,CDC20,FZR1	0.8874	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons