DegronMD

Uniprot ID: Q15398

Source protein: Disks large-associated protein 5

Source gene: DLGAP5

Class: DEG_SCF_FBW7_1

Location: 337:342

E3 ligase: FBXW7

DEGRON score: 0.992

ASA_SCORE: 77.1167

COIL: 0.8457

CONS_SCORE: 0.3833

DSS_SCORE: 0.345

HELIX: 0.0543

FCONS_SCORE: 0.9397

RIG_SCORE: 0.7853

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N334S	TCGA-BA-4077	HNSC	TCGA	LTPSYT	DEG_SCF_FBW7_1	0.25
p.N334S	DO15647	HNSC	ICGC	LTPSYT	DEG_SCF_FBW7_1	0.25
p.R331K	TCGA-D8-A1JA	BRCA	TCGA	LTPSYT	DEG_SCF_FBW7_1	0.1667
p.R331K	DO2819	BRCA	ICGC	LTPSYT	DEG_SCF_FBW7_1	0.1667
p.D351N	TCGA-DK-A1AC	BLCA	TCGA	LTPSYT	DEG_SCF_FBW7_1	0.0833
p.D351N	DO514	BLCA	ICGC	LTPSYT	DEG_SCF_FBW7_1	0.0833
p.P330H	TCGA-EE-A2MQ	SKCM	TCGA	LTPSYT	DEG_SCF_FBW7_1	0.1389
p.P330H	DO37810	SKCM	ICGC	LTPSYT	DEG_SCF_FBW7_1	0.1389
p.E349K	TCGA-LP-A4AV	CESC	TCGA	LTPSYT	DEG_SCF_FBW7_1	0.1389
p.E349K	DO44275	CESC	ICGC	LTPSYT	DEG_SCF_FBW7_1	0.1389
p.V350A	DO227987	COCA	ICGC	LTPSYT	DEG_SCF_FBW7_1	0.1111
p.E352Q	DO228900	LICA	ICGC	LTPSYT	DEG_SCF_FBW7_1	0.0556
p.P345S	DO222702	MELA	ICGC	LTPSYT	DEG_SCF_FBW7_1	0.25
p.R331T	SIDM00870	Breast Carcinoma	GDSC	LTPSYT	DEG_SCF_FBW7_1	0.1667
p.R331T	ACH-000725	Breast Cancer	CCLE	LTPSYT	DEG_SCF_FBW7_1	0.1667
p.R331T	HCC202	breast	COSMIC	LTPSYT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15398	Disks large-associated protein 5	DEG_SCF_FBW7_1	337:342	LTPSYT	FBXW7	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons