DegronMD

Uniprot ID: Q15398

Source protein: Disks large-associated protein 5

Source gene: DLGAP5

Class: DEG_APCC_DBOX_1

Location: 722:730

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7822

ASA_SCORE: 85.5

COIL: 0.7279

CONS_SCORE: 0.3179

DSS_SCORE: 0.2506

HELIX: 0.2203

FCONS_SCORE: 1.1448

RIG_SCORE: 0.789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M724I	TCGA-39-5028	LUSC	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	0.6507
p.M724I	TCGA-56-A4ZK	LUSC	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	0.6507
p.M724I	DO26442	LUSC	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.6507
p.M724I	DO45496	LUSC	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.6507
p.P727S	TCGA-AX-A1CE	UCEC	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	0.5641
p.P727S	DO42280	UCEC	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.5641
p.S725G	TCGA-D1-A0ZS	UCEC	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	0.6993
p.S725G	DO43626	UCEC	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.6993
p.L714F	TCGA-DK-A2I4	BLCA	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	0.1111
p.L714F	DO465	BLCA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.1111
p.S720F	TCGA-DU-6407	LGG	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	0.7222
p.S720F	DO22295	LGG	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.7222
p.P727H	TCGA-EE-A2M7	SKCM	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	0.6583
p.P727H	DO37847	SKCM	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.6583
p.P727H	SIDM01074	Glioblastoma	GDSC	ERMSLPLLA	DEG_APCC_DBOX_1	0.6583
p.P727H	ACH-000102	Brain Cancer	CCLE	ERMSLPLLA	DEG_APCC_DBOX_1	0.6583
p.P727H	GMS-10	central_nervous_system	COSMIC	ERMSLPLLA	DEG_APCC_DBOX_1	0.6583
p.L728V	TCGA-FD-A3B6	BLCA	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	0.5654
p.L728V	DO458	BLCA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.5654
p.A734T	TCGA-IB-AAUQ	PAAD	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	0.2222
p.A734T	DO51705	PAAD	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.2222
p.R723K	TCGA-XF-A8HI	BLCA	TCGA	ERMSLPLLA	DEG_APCC_DBOX_1	0.7237
p.R723K	DO51911	BLCA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.7237
p.D713H	DO1094	BRCA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.0833
p.E722D	DO1094	BRCA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.5647
p.S721N	DO227504	LAML	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.75
p.D713E	DO229019	LICA	ICGC	ERMSLPLLA	DEG_APCC_DBOX_1	0.0833
p.D713V	ACH-000982	Colon/Colorectal Cancer	CCLE	ERMSLPLLA	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15398	Disks large-associated protein 5	DEG_APCC_DBOX_1	722:730	ERMSLPLLA	APC,CDC20,FZR1	0.7822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERMSLPLLA

Degron related mutations and impact score

Drug responses associated with DLGAP5 mutations

All proteins holding degron of ERMSLPLLA