DegronMD - Q8TC05(MDM1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E708D	TCGA-AA-3977	COAD	TCGA	RKENF	DEG_APCC_KENBOX_2	706:710	Mutation altering degron motif	0.6758
p.E708D	DO8730	COAD	ICGC	RKENF	DEG_APCC_KENBOX_2	706:710	Mutation altering degron motif	0.6758
p.V383A	TCGA-AD-6964	COAD	TCGA	VSSTT	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.1667
p.K707N	TCGA-BG-A222	UCEC	TCGA	RKENF	DEG_APCC_KENBOX_2	706:710	Mutation altering degron motif	0.6918
p.K707N	DO42977	UCEC	ICGC	RKENF	DEG_APCC_KENBOX_2	706:710	Mutation altering degron motif	0.6918
p.R706M	TCGA-E6-A1LX	UCEC	TCGA	RKENF	DEG_APCC_KENBOX_2	706:710	Mutation altering degron motif	0.7521
p.R706M	DO41020	UCEC	ICGC	RKENF	DEG_APCC_KENBOX_2	706:710	Mutation altering degron motif	0.7521
p.L700V	TCGA-GM-A2D9	BRCA	TCGA	RKENF	DEG_APCC_KENBOX_2	706:710	Mutation rewiring degron network	0.1667
p.L700V	DO4810	BRCA	ICGC	RKENF	DEG_APCC_KENBOX_2	706:710	Mutation rewiring degron network	0.1667
p.S372F	DO2401	BRCA	ICGC	VSSTT	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.3056
p.S372F	DO48981	CESC	ICGC	VSSTT	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.3056
p.A696D	DO229041	LICA	ICGC	RKENF	DEG_APCC_KENBOX_2	706:710	Mutation rewiring degron network	0.0556
p.K365N	DO40884	UCEC	ICGC	VSSTT	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.1111
p.Q387H	DO42472	UCEC	ICGC	VSSTT	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.0556
p.F374C	ACH-000608	Ovarian Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	373:377	Mutation altering degron motif	0.7108
p.N385H	ACH-001991	Primary	CCLE	VSSTT	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.1111
p.S363N	Caov-4	ovary	COSMIC	VSSTT	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.0556
p.S363N	JAR	placenta	COSMIC	VSSTT	DEG_SPOP_SBC_1	373:377	Mutation rewiring degron network	0.0556

Kaplan plot for MDM1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MDM1

UniProt ID: Q8TC05

Entrez ID: 56890

Protein name: Nuclear protein MDM1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MDM1 in