DegronMD

Uniprot ID: Q8TC05

Source protein: Nuclear protein MDM1

Source gene: MDM1

Class: DEG_APCC_KENBOX_2

Location: 706:710

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5277

ASA_SCORE: 99.5

COIL: 0.3268

CONS_SCORE: 0.3417

DSS_SCORE: 0.6219

HELIX: 0.6722

FCONS_SCORE: 0.9911

RIG_SCORE: 0.7543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E708D	TCGA-AA-3977	COAD	TCGA	RKENF	DEG_APCC_KENBOX_2	0.6758
p.E708D	DO8730	COAD	ICGC	RKENF	DEG_APCC_KENBOX_2	0.6758
p.K707N	TCGA-BG-A222	UCEC	TCGA	RKENF	DEG_APCC_KENBOX_2	0.6918
p.K707N	DO42977	UCEC	ICGC	RKENF	DEG_APCC_KENBOX_2	0.6918
p.R706M	TCGA-E6-A1LX	UCEC	TCGA	RKENF	DEG_APCC_KENBOX_2	0.7521
p.R706M	DO41020	UCEC	ICGC	RKENF	DEG_APCC_KENBOX_2	0.7521
p.L700V	TCGA-GM-A2D9	BRCA	TCGA	RKENF	DEG_APCC_KENBOX_2	0.1667
p.L700V	DO4810	BRCA	ICGC	RKENF	DEG_APCC_KENBOX_2	0.1667
p.A696D	DO229041	LICA	ICGC	RKENF	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TC05	Nuclear protein MDM1	DEG_APCC_KENBOX_2	706:710	RKENF	APC,CDC20,FZR1	0.5277	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons