DegronMD

Uniprot ID: Q8TC05

Source protein: Nuclear protein MDM1

Source gene: MDM1

Class: DEG_SPOP_SBC_1

Location: 373:377

E3 ligase: SPOP

DEGRON score: 0.9916

ASA_SCORE: 85.64

COIL: 0.9528

CONS_SCORE: 0.5924

DSS_SCORE: 0.344

HELIX: 0.0268

FCONS_SCORE: 1.1352

RIG_SCORE: 0.7311

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V383A	TCGA-AD-6964	COAD	TCGA	VSSTT	DEG_SPOP_SBC_1	0.1667
p.S372F	DO2401	BRCA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.3056
p.S372F	DO48981	CESC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.3056
p.K365N	DO40884	UCEC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1111
p.Q387H	DO42472	UCEC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.0556
p.F374C	ACH-000608	Ovarian Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	0.7108
p.N385H	ACH-001991	Primary	CCLE	VSSTT	DEG_SPOP_SBC_1	0.1111
p.S363N	Caov-4	ovary	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.0556
p.S363N	JAR	placenta	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	656:660	VSSTT	SPOP	0.9967	More...
Q15398	Disks large-associated protein 5	DEG_SPOP_SBC_1	220:224	VSSTT	SPOP	0.781	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	420:424	VSSTT	SPOP	0.9437	More...
Q8NHH9	Atlastin-2	DEG_SPOP_SBC_1	33:37	VSSTT	SPOP	0.999	More...
Q8TBY9	Cilia- and flagella-associated protein 251	DEG_SPOP_SBC_1	229:233	VSSTT	SPOP	0.9658	More...
Q8TC05	Nuclear protein MDM1	DEG_SPOP_SBC_1	373:377	VSSTT	SPOP	0.9916	More...
Q8TF66	Leucine-rich repeat-containing protein 15	DEG_SPOP_SBC_1	502:506	VSSTT	SPOP	0.584	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1165:1169	VSSTT	SPOP	0.9972	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	354:358	VSSTT	SPOP	0.9025	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	845:849	VSSTT	SPOP	0.9657	More...
A6NMB9	Fidgetin-like protein 2	DEG_SPOP_SBC_1	21:25	VSSTT	SPOP	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons