DegronMD

Uniprot ID: Q96K83

Source protein: Zinc finger protein 521

Source gene: ZNF521

Class: DEG_SPOP_SBC_1

Location: 354:358

E3 ligase: SPOP

DEGRON score: 0.9025

ASA_SCORE: 66.34

COIL: 0.7172

CONS_SCORE: 0.2941

DSS_SCORE: 0.4762

HELIX: 0.0472

FCONS_SCORE: 0.742

RIG_SCORE: 0.6314

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G350V	TCGA-05-4382	LUAD	TCGA	VSSTT	DEG_SPOP_SBC_1	0.2222
p.G350V	DO24900	LUAD	ICGC	VSSTT	DEG_SPOP_SBC_1	0.2222
p.L363F	TCGA-22-4599	LUSC	TCGA	VSSTT	DEG_SPOP_SBC_1	0.1944
p.L363F	DO26945	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.V347A	TCGA-55-7227	LUAD	TCGA	VSSTT	DEG_SPOP_SBC_1	0.1389
p.V347A	DO24050	LUAD	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1389
p.T357M	TCGA-63-A5M9	LUSC	TCGA	VSSTT	DEG_SPOP_SBC_1	0.7423
p.T357M	TCGA-86-8358	LUAD	TCGA	VSSTT	DEG_SPOP_SBC_1	0.7423
p.T357M	TCGA-SW-A7EB	STAD	TCGA	VSSTT	DEG_SPOP_SBC_1	0.7423
p.T357M	DO25471	LUAD	ICGC	VSSTT	DEG_SPOP_SBC_1	0.7423
p.T357M	DO223726	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.7423
p.T357M	DO50143	STAD	ICGC	VSSTT	DEG_SPOP_SBC_1	0.7423
p.T357M	SIDM01151	Hepatocellular Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.7423
p.T357M	ACH-000483	Liver Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	0.7423
p.T357M	SNU-182	liver	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.7423
p.L363V	TCGA-75-6211	LUAD	TCGA	VSSTT	DEG_SPOP_SBC_1	0.1944
p.L363V	DO25173	LUAD	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.S353F	TCGA-CV-7568	HNSC	TCGA	VSSTT	DEG_SPOP_SBC_1	0.3056
p.S353F	DO14160	HNSC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.3056
p.V354M	TCGA-IB-7651	PAAD	TCGA	VSSTT	DEG_SPOP_SBC_1	0.7208
p.V354M	TCGA-VS-A9UI	CESC	TCGA	VSSTT	DEG_SPOP_SBC_1	0.7208
p.V354M	DO219734	CESC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.7208
p.V354M	DO46657	PAAD	ICGC	VSSTT	DEG_SPOP_SBC_1	0.7208
p.V354M	SIDM00510	Small Cell Lung Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.7208
p.V354M	ACH-002095	Lung Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	0.7208
p.V354M	COR-L303	lung	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.7208
p.T348R	TCGA-VQ-A8DZ	STAD	TCGA	VSSTT	DEG_SPOP_SBC_1	0.1667
p.T348R	DO51755	STAD	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1667
p.T348M	DO217822	GACA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1667
p.Y351H	DO228416	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.25
p.P349S	SW684	soft_tissue	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.N347D	WM793B	skin	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	656:660	VSSTT	SPOP	0.9967	More...
Q15398	Disks large-associated protein 5	DEG_SPOP_SBC_1	220:224	VSSTT	SPOP	0.781	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	420:424	VSSTT	SPOP	0.9437	More...
Q8NHH9	Atlastin-2	DEG_SPOP_SBC_1	33:37	VSSTT	SPOP	0.999	More...
Q8TBY9	Cilia- and flagella-associated protein 251	DEG_SPOP_SBC_1	229:233	VSSTT	SPOP	0.9658	More...
Q8TC05	Nuclear protein MDM1	DEG_SPOP_SBC_1	373:377	VSSTT	SPOP	0.9916	More...
Q8TF66	Leucine-rich repeat-containing protein 15	DEG_SPOP_SBC_1	502:506	VSSTT	SPOP	0.584	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1165:1169	VSSTT	SPOP	0.9972	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	354:358	VSSTT	SPOP	0.9025	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	845:849	VSSTT	SPOP	0.9657	More...
A6NMB9	Fidgetin-like protein 2	DEG_SPOP_SBC_1	21:25	VSSTT	SPOP	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSTT

Degron related mutations and impact score

Drug responses associated with ZNF521 mutations

All proteins holding degron of VSSTT