DegronMD

Uniprot ID: Q8NHH9

Source protein: Atlastin-2

Source gene: ATL2

Class: DEG_SPOP_SBC_1

Location: 33:37

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 79.18

COIL: 0.8692

CONS_SCORE: 0.2904

DSS_SCORE: 0.5915

HELIX: 0.0692

FCONS_SCORE: 1.0021

RIG_SCORE: 0.6603

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S34L	TCGA-4Z-AA84	BLCA	TCGA	VSSTT	DEG_SPOP_SBC_1	0.7667
p.S34L	DO218988	BLCA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.7667
p.S27R	TCGA-51-4079	LUSC	TCGA	VSSTT	DEG_SPOP_SBC_1	0.6111
p.S27R	DO26437	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.6111
p.P26Q	TCGA-EE-A2GT	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	0.1389
p.P26Q	DO37946	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1389
p.E35Q	DO761	BLCA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.6744
p.L47V	DO2401	BRCA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.0556
p.P42L	DO228422	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.P40Q	DO228976	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.25
p.Q44K	DO229027	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1389
p.L47F	DO23666	LUAD	ICGC	VSSTT	DEG_SPOP_SBC_1	0.0556
p.K38R	DO228177	PBCA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.75
p.S38P	DO229218	THCA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.75
p.V33I	SIDM00433	T-Lymphoblastic Leukemia	GDSC	VSSTT	DEG_SPOP_SBC_1	0.7076
p.V33I	ACH-000795	Leukemia	CCLE	VSSTT	DEG_SPOP_SBC_1	0.7076
p.V33I	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.7076
p.N42D	SIDM00845	Burkitt's Lymphoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.D47G	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.0556
p.D47G	ACH-000438	Lung Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	0.0556
p.D47G	LU-65	lung	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.0556
p.T37A	SIDM01045	Endometrial Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.7139
p.T37A	ACH-000978	Endometrial/Uterine Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	0.7139
p.T37A	EN	endometrium	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.7139
p.D29G	LU-65	lung	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	656:660	VSSTT	SPOP	0.9967	More...
Q15398	Disks large-associated protein 5	DEG_SPOP_SBC_1	220:224	VSSTT	SPOP	0.781	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	420:424	VSSTT	SPOP	0.9437	More...
Q8NHH9	Atlastin-2	DEG_SPOP_SBC_1	33:37	VSSTT	SPOP	0.999	More...
Q8TBY9	Cilia- and flagella-associated protein 251	DEG_SPOP_SBC_1	229:233	VSSTT	SPOP	0.9658	More...
Q8TC05	Nuclear protein MDM1	DEG_SPOP_SBC_1	373:377	VSSTT	SPOP	0.9916	More...
Q8TF66	Leucine-rich repeat-containing protein 15	DEG_SPOP_SBC_1	502:506	VSSTT	SPOP	0.584	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1165:1169	VSSTT	SPOP	0.9972	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	354:358	VSSTT	SPOP	0.9025	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	845:849	VSSTT	SPOP	0.9657	More...
A6NMB9	Fidgetin-like protein 2	DEG_SPOP_SBC_1	21:25	VSSTT	SPOP	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons