DegronMD - O14974(PPP1R12A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T807I	TCGA-55-8511	LUAD	TCGA	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.1111
p.T807I	DO24940	LUAD	ICGC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.1111
p.T646R	TCGA-59-2351	OV	TCGA	AASTT	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.7876
p.T646R	DO31240	OV	ICGC	AASTT	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.7876
p.A629S	TCGA-62-A46P	LUAD	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7588
p.A629S	DO25767	LUAD	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7588
p.Q767R	TCGA-63-A5ML	LUSC	TCGA	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2222
p.Q767R	DO219151	LUSC	ICGC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2222
p.I814L	TCGA-77-7463	LUSC	TCGA	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.3056
p.I814L	DO26716	LUSC	ICGC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.3056
p.S657F	TCGA-77-A5G3	LUSC	TCGA	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation altering degron motif	0.6871
p.S657F	TCGA-DK-AA6U	BLCA	TCGA	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation altering degron motif	0.6871
p.S657F	DO219008	BLCA	ICGC	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation altering degron motif	0.6871
p.S657F	DO45456	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation altering degron motif	0.6871
p.Q681K	TCGA-85-6561	LUSC	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.1389
p.Q681K	DO26518	LUSC	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.1389
p.P568S	TCGA-A5-A1OF	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.5641
p.P568S	DO42568	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.5641
p.A629V	TCGA-AX-A2HD	UCEC	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.5825
p.A629V	DO42608	UCEC	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.5825
p.T761M	TCGA-B5-A3FC	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation blocking phosphorylation signal	0.5
p.T761M	TCGA-D1-A103	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation blocking phosphorylation signal	0.5
p.T761M	DO42312	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation blocking phosphorylation signal	0.5
p.T761M	DO41871	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation blocking phosphorylation signal	0.5
p.V626F	TCGA-BH-A0DK	BRCA	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7068
p.V626F	DO1305	BRCA	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7068
p.T807P	TCGA-CK-4951	COAD	TCGA	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.1111
p.T807P	DO10582	COAD	ICGC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.1111
p.A391T	TCGA-CN-6988	HNSC	TCGA	VTTPTVS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.2222
p.A391T	DO14208	HNSC	ICGC	VTTPTVS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.2222
p.E616D	TCGA-D3-A2JN	SKCM	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation rewiring degron network	0.3056
p.E616D	DO47590	SKCM	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation rewiring degron network	0.3056
p.T609A	TCGA-DI-A1BU	UCEC	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation blocking phosphorylation signal	0.5556
p.T609A	DO42023	UCEC	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation blocking phosphorylation signal	0.5556
p.R667I	TCGA-DS-A1OB	CESC	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.8102
p.R667I	DO6323	CESC	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.8102
p.A615V	TCGA-DX-AB2Q	SARC	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2778
p.A615V	DO220087	SARC	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2778
p.L562V	TCGA-EY-A1GI	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1944
p.L562V	DO41211	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1944
p.S565C	TCGA-FJ-A3Z7	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2778
p.S565C	DO463	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2778
p.S565C	SIDM00845	Burkitt's Lymphoma	GDSC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2778
p.S565C	SIDM00461	Acute Myeloid Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2778
p.S565C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2778
p.S565C	SIDM01519	Head and Neck Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2778
p.S565C	ACH-000786	Lymphoma	CCLE	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2778
p.S565C	ACH-000992	Head and Neck Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2778
p.S658Y	TCGA-FS-A1ZP	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation altering degron motif	0.712
p.S658Y	DO37703	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation altering degron motif	0.712
p.P392H	TCGA-GN-A265	SKCM	TCGA	VTTPTVS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.25
p.P392H	DO37491	SKCM	ICGC	VTTPTVS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.25
p.R557K	TCGA-XF-AAN2	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0556
p.R557K	DO219052	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0556
p.R768H	DO229389	BTCA	ICGC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.25
p.R638T	DO6254	CESC	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation rewiring degron network	0.0833
p.R638T	DO6254	CESC	ICGC	AASTT	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.2222
p.T631A	DO227802	COCA	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation blocking phosphorylation signal	0.7222
p.R666H	DO222737	COCA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.7133
p.R666C	DO50442	ESAD	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.719
p.G813V	DO222750	ESCA	ICGC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.2778
p.E764K	DO14566	HNSC	ICGC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1389
p.P771Q	DO228952	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation altering degron motif	0.7035
p.T765N	DO228974	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation blocking phosphorylation signal	0.6111
p.T659K	DO229019	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation altering degron motif	0.7306
p.T661N	DO229028	LICA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.1944
p.T661N	DO229028	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation rewiring degron network	0.3056
p.T661N	DO229037	LICA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.1944
p.T661N	DO229037	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation rewiring degron network	0.3056
p.A580D	DO229025	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0833
p.T628K	DO229027	LICA	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7306
p.T650K	DO229036	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.2222
p.T650K	DO229036	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation rewiring degron network	0.1667
p.Q649K	DO229041	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.25
p.Q649K	DO229041	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation rewiring degron network	0.1389
p.K829E	DO229052	LICA	ICGC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation substituting flanking lysine	0.1667
p.E672K	DO229052	LICA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.7022
p.E672K	DO229054	LICA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.7022
p.A684G	DO52686	MALY	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.0556
p.P780S	DO220879	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1944
p.R612C	DO37074	READ	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation rewiring degron network	0.1944
p.T779A	SIDM00625	Other Sarcomas	GDSC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2222
p.T779A	MES-SA	soft tissue	COSMIC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2222
p.V626A	SIDM00845	Burkitt's Lymphoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.6936
p.V626A	SIDM00461	Acute Myeloid Leukemia	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.6936
p.V626A	SIDM01519	Head and Neck Carcinoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.6936
p.V626A	ACH-000786	Lymphoma	CCLE	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.6936
p.V626A	ACH-000992	Head and Neck Cancer	CCLE	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.6936
p.V626A	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.6936
p.A405T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VTTPTVS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.2222
p.A405T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VTTPTVS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.2222
p.Q767H	SIDM00885	Breast Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2222
p.Q767H	ACH-000111	Breast Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2222
p.Q767H	HCC1187	breast	COSMIC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.2222
p.T628M	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7423
p.T628M	SIDM00878	Breast Carcinoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7423
p.T628M	SIDM01101	Neuroblastoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7423
p.R820K	SIDM00998	Glioblastoma	GDSC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.3056
p.R820K	SIDM00391	Plasma Cell Myeloma	GDSC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.3056
p.R820K	8-MG-BA	central nervous system	COSMIC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.3056
p.R820K	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.3056
p.T619A	SIDM00333	Endometrial Carcinoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7139
p.T619A	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7139
p.T619A	MFE-319	endometrium	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7139
p.L613S	SIDM01113	Other Sarcomas	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.L613S	ACH-000939	Sarcoma	CCLE	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.L613S	SK-UT-1	soft tissue	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.T619N	SIDM00683	Prostate Carcinoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7055
p.T619N	ACH-000977	lymph node	CCLE	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7055
p.T619N	LNCaP-Clone-FGC	prostate	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.7055
p.A394S	SIDM00710	Small Cell Lung Carcinoma	GDSC	VTTPTVS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.3056
p.A394S	ACH-000394	Lung Cancer	CCLE	VTTPTVS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.3056
p.A394S	NCI-H2081	lung	COSMIC	VTTPTVS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.3056
p.I814T	SIDM00720	Mesothelioma	GDSC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.3056
p.I814T	SIDM01664	Prostate Carcinoma	GDSC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.3056
p.E679K	ACH-000712	Lung Cancer	CCLE	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.1944
p.T563A	MFE-319	endometrium	COSMIC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2222
p.R673T	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.7876
p.R633T	D-423MG	central nervous system	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.R633T	D-423MG	central nervous system	COSMIC	AASTT	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.0833
p.Q680H	HCC1187	breast	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation blocking phosphorylation signal	0.6111
p.R628L	NCI-H2347	lung	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	617:629	Mutation altering degron motif	0.8428
p.R664T	D-423MG	central nervous system	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.2778
p.R664T	D-423MG	central nervous system	COSMIC	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation rewiring degron network	0.2222
p.R764K	8-MG-BA	central nervous system	COSMIC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1389
p.R764K	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	PVSTS	DEG_SPOP_SBC_1	771:775	Mutation rewiring degron network	0.1389
p.L557S	SK-UT-1	soft tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0556
p.R659L	NCI-H2347	lung	COSMIC	VSSTT	DEG_SPOP_SBC_1	656:660	Mutation altering degron motif	0.8428
p.T563N	LNCaP-Clone-FGC	prostate	COSMIC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2222
p.R820H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	TKENE	DEG_APCC_KENBOX_2	815:819	Mutation rewiring degron network	0.3056
p.L407V	H2373	pleura	COSMIC	VTTPTVS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.1667
p.V570A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R12A

UniProt ID: O14974

Entrez ID: 4659

Protein name: Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP1R12A in