DegronMD

Uniprot ID: O14974

Source protein: Protein phosphatase 1 regulatory subunit 12A

Source gene: PPP1R12A

Class: DEG_COP1_1

Location: 617:629

E3 ligase: COP1

DEGRON score: 0.9994

ASA_SCORE: 102.6769

COIL: 0.7701

CONS_SCORE: 0.3334

DSS_SCORE: 0.5491

HELIX: 0.2145

FCONS_SCORE: 0.9912

RIG_SCORE: 0.7222

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A629S	TCGA-62-A46P	LUAD	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	0.7588
p.A629S	DO25767	LUAD	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	0.7588
p.A629V	TCGA-AX-A2HD	UCEC	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	0.5825
p.A629V	DO42608	UCEC	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	0.5825
p.V626F	TCGA-BH-A0DK	BRCA	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	0.7068
p.V626F	DO1305	BRCA	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	0.7068
p.E616D	TCGA-D3-A2JN	SKCM	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	0.3056
p.E616D	DO47590	SKCM	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	0.3056
p.T609A	TCGA-DI-A1BU	UCEC	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	0.5556
p.T609A	DO42023	UCEC	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	0.5556
p.A615V	TCGA-DX-AB2Q	SARC	TCGA	DSTEKEKDSVPTA	DEG_COP1_1	0.2778
p.A615V	DO220087	SARC	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	0.2778
p.R638T	DO6254	CESC	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	0.0833
p.T631A	DO227802	COCA	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	0.7222
p.T628K	DO229027	LICA	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	0.7306
p.R612C	DO37074	READ	ICGC	DSTEKEKDSVPTA	DEG_COP1_1	0.1944
p.V626A	SIDM00845	Burkitt's Lymphoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	0.6936
p.V626A	SIDM00461	Acute Myeloid Leukemia	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	0.6936
p.V626A	SIDM01519	Head and Neck Carcinoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	0.6936
p.V626A	ACH-000786	Lymphoma	CCLE	DSTEKEKDSVPTA	DEG_COP1_1	0.6936
p.V626A	ACH-000992	Head and Neck Cancer	CCLE	DSTEKEKDSVPTA	DEG_COP1_1	0.6936
p.V626A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	0.6936
p.T628M	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	0.7423
p.T628M	SIDM00878	Breast Carcinoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	0.7423
p.T628M	SIDM01101	Neuroblastoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	0.7423
p.T619A	SIDM00333	Endometrial Carcinoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	0.7139
p.T619A	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSTEKEKDSVPTA	DEG_COP1_1	0.7139
p.T619A	MFE-319	endometrium	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	0.7139
p.L613S	SIDM01113	Other Sarcomas	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	0.2222
p.L613S	ACH-000939	Sarcoma	CCLE	DSTEKEKDSVPTA	DEG_COP1_1	0.2222
p.L613S	SK-UT-1	soft_tissue	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	0.2222
p.T619N	SIDM00683	Prostate Carcinoma	GDSC	DSTEKEKDSVPTA	DEG_COP1_1	0.7055
p.T619N	ACH-000977	lymph_node	CCLE	DSTEKEKDSVPTA	DEG_COP1_1	0.7055
p.T619N	LNCaP-Clone-FGC	prostate	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	0.7055
p.R633T	D-423MG	central_nervous_system	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	0.2222
p.R628L	NCI-H2347	lung	COSMIC	DSTEKEKDSVPTA	DEG_COP1_1	0.8428

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSTEKEKDSVPTA

Degron related mutations and impact score

Drug responses associated with PPP1R12A mutations

All proteins holding degron of DSTEKEKDSVPTA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_COP1_1	617:629	DSTEKEKDSVPTA	COP1	0.9994	More...