DegronMD

Uniprot ID: O14974

Source protein: Protein phosphatase 1 regulatory subunit 12A

Source gene: PPP1R12A

Class: DEG_SCF_FBW7_1

Location: 395:401

E3 ligase: FBXW7

DEGRON score: 0.9748

ASA_SCORE: 86.6

COIL: 0.9317

CONS_SCORE: 0.3443

DSS_SCORE: 0.5601

HELIX: 0.0157

FCONS_SCORE: 0.9178

RIG_SCORE: 0.7082

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A391T	TCGA-CN-6988	HNSC	TCGA	VTTPTVS	DEG_SCF_FBW7_1	0.2222
p.A391T	DO14208	HNSC	ICGC	VTTPTVS	DEG_SCF_FBW7_1	0.2222
p.P392H	TCGA-GN-A265	SKCM	TCGA	VTTPTVS	DEG_SCF_FBW7_1	0.25
p.P392H	DO37491	SKCM	ICGC	VTTPTVS	DEG_SCF_FBW7_1	0.25
p.A405T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VTTPTVS	DEG_SCF_FBW7_1	0.2222
p.A405T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VTTPTVS	DEG_SCF_FBW7_1	0.2222
p.A394S	SIDM00710	Small Cell Lung Carcinoma	GDSC	VTTPTVS	DEG_SCF_FBW7_1	0.3056
p.A394S	ACH-000394	Lung Cancer	CCLE	VTTPTVS	DEG_SCF_FBW7_1	0.3056
p.A394S	NCI-H2081	lung	COSMIC	VTTPTVS	DEG_SCF_FBW7_1	0.3056
p.L407V	H2373	pleura	COSMIC	VTTPTVS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SCF_FBW7_1	395:401	VTTPTVS	FBXW7	0.9748	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons