DegronMD

Uniprot ID: O14974

Source protein: Protein phosphatase 1 regulatory subunit 12A

Source gene: PPP1R12A

Class: DEG_APCC_DBOX_1

Location: 666:674

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9938

ASA_SCORE: 110.5444

COIL: 0.7684

CONS_SCORE: 0.488

DSS_SCORE: 0.6373

HELIX: 0.1461

FCONS_SCORE: 1.2237

RIG_SCORE: 0.7295

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q681K	TCGA-85-6561	LUSC	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	0.1389
p.Q681K	DO26518	LUSC	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.1389
p.R667I	TCGA-DS-A1OB	CESC	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	0.8102
p.R667I	DO6323	CESC	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.8102
p.R666H	DO222737	COCA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.7133
p.R666C	DO50442	ESAD	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.719
p.T661N	DO229028	LICA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.1944
p.T661N	DO229037	LICA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.1944
p.E672K	DO229052	LICA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.7022
p.E672K	DO229054	LICA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.7022
p.A684G	DO52686	MALY	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.0556
p.E679K	ACH-000712	Lung Cancer	CCLE	RRSYLTPVR	DEG_APCC_DBOX_1	0.1944
p.R673T	ALL-PO	haematopoietic_and_lymphoid_tissue	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	0.7876
p.Q680H	HCC1187	breast	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	0.6111
p.R664T	D-423MG	central_nervous_system	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_APCC_DBOX_1	666:674	RRSYLTPVR	APC,CDC20,FZR1	0.9938	More...
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_APCC_DBOX_1	616:624	RRSYLTPVR	APC,CDC20,FZR1	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons