DegronMD

Uniprot ID: O60237

Source protein: Protein phosphatase 1 regulatory subunit 12B

Source gene: PPP1R12B

Class: DEG_APCC_DBOX_1

Location: 616:624

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9836

ASA_SCORE: 103.0444

COIL: 0.627

CONS_SCORE: 0.4912

DSS_SCORE: 0.5465

HELIX: 0.341

FCONS_SCORE: 1.0137

RIG_SCORE: 0.7319

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E627G	TCGA-AX-A06H	UCEC	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	0.25
p.E627G	DO43530	UCEC	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.25
p.S630C	TCGA-CV-6936	HNSC	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	0.1667
p.S630C	DO14210	HNSC	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.1667
p.R624L	TCGA-D3-A2JO	SKCM	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	0.7316
p.R624L	TCGA-ET-A39R	THCA	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	0.7316
p.R624L	DO47619	SKCM	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.7316
p.R624L	DO39552	THCA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.7316
p.R624L	ACH-000871	Lung Cancer	CCLE	RRSYLTPVR	DEG_APCC_DBOX_1	0.7316
p.R624L	NCI-H510A	lung	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	0.7316
p.E626D	TCGA-FS-A1Z0	SKCM	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	0.2778
p.E626D	DO37431	SKCM	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.2778
p.P622L	TCGA-FW-A3R5	SKCM	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	0.6471
p.P622L	DO37406	SKCM	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.6471
p.S618F	DO222731	MELA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.7982
p.R617S	DO229264	THCA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.7427
p.K615E	DO229268	THCA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.3056
p.R632W	DO229250	THCA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	0.1111
p.A607T	SIDM00845	Burkitt's Lymphoma	GDSC	RRSYLTPVR	DEG_APCC_DBOX_1	0.0833
p.A607T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	0.0833
p.D633Y	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	RRSYLTPVR	DEG_APCC_DBOX_1	0.1944
p.D633Y	NCI-H810	lung	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	0.1944
p.T609S	SIDM00856	Other Solid Cancers	GDSC	RRSYLTPVR	DEG_APCC_DBOX_1	0.1389
p.T609S	G-401	soft_tissue	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	0.1389
p.A624T	SIDM01695	Acute Myeloid Leukemia	GDSC	RRSYLTPVR	DEG_APCC_DBOX_1	0.7139
p.D625G	SIDM01617	Endometrial Carcinoma	GDSC	RRSYLTPVR	DEG_APCC_DBOX_1	0.3056
p.V610L	ACH-000443	Ovarian Cancer	CCLE	RRSYLTPVR	DEG_APCC_DBOX_1	0.1667
p.V610L	OVKATE	ovary	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	0.1667
p.R613W	ACH-001233	Lung Cancer	CCLE	RRSYLTPVR	DEG_APCC_DBOX_1	0.25
p.R613W	VMRC-LCD	lung	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_APCC_DBOX_1	666:674	RRSYLTPVR	APC,CDC20,FZR1	0.9938	More...
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_APCC_DBOX_1	616:624	RRSYLTPVR	APC,CDC20,FZR1	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRSYLTPVR

Degron related mutations and impact score

Drug responses associated with PPP1R12B mutations

All proteins holding degron of RRSYLTPVR