DegronMD - O60237(PPP1R12B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T566I	TCGA-12-1089	GBM	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.1944
p.T566I	TCGA-12-1089	GBM	TCGA	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.T566I	DO12346	GBM	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.1944
p.T566I	DO12346	GBM	ICGC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.G594R	TCGA-19-1790	GBM	TCGA	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.3056
p.G594R	DO12328	GBM	ICGC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.3056
p.L588F	TCGA-55-7911	LUAD	TCGA	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1389
p.L588F	TCGA-55-7911	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.L588F	TCGA-DS-A0VM	CESC	TCGA	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1389
p.L588F	TCGA-DS-A0VM	CESC	TCGA	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.L588F	DO6258	CESC	ICGC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1389
p.L588F	DO6258	CESC	ICGC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.L588F	DO24821	LUAD	ICGC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1389
p.L588F	DO24821	LUAD	ICGC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.R586H	TCGA-AA-3842	COAD	TCGA	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.0833
p.R586H	TCGA-AA-3842	COAD	TCGA	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.R586H	TCGA-BR-4184	STAD	TCGA	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.0833
p.R586H	TCGA-BR-4184	STAD	TCGA	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.R586H	DO9394	COAD	ICGC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.0833
p.R586H	DO9394	COAD	ICGC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.R586H	DO38328	STAD	ICGC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.0833
p.R586H	DO38328	STAD	ICGC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.R556M	TCGA-AP-A051	UCEC	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.7521
p.R556M	DO42673	UCEC	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.7521
p.E568D	TCGA-AP-A0LM	UCEC	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.1389
p.E568D	TCGA-AP-A0LM	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.E568D	DO43306	UCEC	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.1389
p.E568D	DO43306	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.P579Q	TCGA-AP-A1DR	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.3056
p.P579Q	DO43747	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.3056
p.E627G	TCGA-AX-A06H	UCEC	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.25
p.E627G	DO43530	UCEC	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.25
p.K555T	TCGA-AZ-4315	COAD	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.6195
p.K555T	DO8842	COAD	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.6195
p.D564N	TCGA-BR-8680	STAD	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.25
p.D564N	TCGA-BR-8680	STAD	TCGA	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.D564N	DO233884	GACA	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.25
p.D564N	DO233884	GACA	ICGC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.D564N	DO47769	STAD	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.25
p.D564N	DO47769	STAD	ICGC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.S630C	TCGA-CV-6936	HNSC	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1667
p.S630C	DO14210	HNSC	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1667
p.R624L	TCGA-D3-A2JO	SKCM	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation altering degron motif	0.7316
p.R624L	TCGA-ET-A39R	THCA	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation altering degron motif	0.7316
p.R624L	DO47619	SKCM	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation altering degron motif	0.7316
p.R624L	DO39552	THCA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation altering degron motif	0.7316
p.R624L	ACH-000871	Lung Cancer	CCLE	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation altering degron motif	0.7316
p.R624L	NCI-H510A	lung	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation altering degron motif	0.7316
p.S547P	TCGA-E2-A1IF	BRCA	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.1389
p.S547P	DO4701	BRCA	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.1389
p.V518G	TCGA-EE-A3AF	SKCM	TCGA	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation rewiring degron network	0.2222
p.V518G	DO37911	SKCM	ICGC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation rewiring degron network	0.2222
p.S561F	TCGA-FR-A726	SKCM	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.9093
p.S561F	DO48665	SKCM	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.9093
p.E626D	TCGA-FS-A1Z0	SKCM	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.2778
p.E626D	DO37431	SKCM	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.2778
p.P622L	TCGA-FW-A3R5	SKCM	TCGA	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation altering degron motif	0.6471
p.P622L	DO37406	SKCM	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation altering degron motif	0.6471
p.R500L	TCGA-HJ-7597	STAD	TCGA	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation rewiring degron network	0.0556
p.R500L	DO38195	STAD	ICGC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation rewiring degron network	0.0556
p.N513H	DO7801	COAD	ICGC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation altering degron motif	0.7423
p.L601F	DO229003	COCA	ICGC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation altering degron motif	0.587
p.F502S	DO14518	HNSC	ICGC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation rewiring degron network	0.1111
p.F502S	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation rewiring degron network	0.1111
p.F502S	SIDM00781	Colorectal Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation rewiring degron network	0.1111
p.F502S	HT	haematopoietic and lymphoid tissue	COSMIC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation rewiring degron network	0.1111
p.A592D	DO229036	LICA	ICGC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.25
p.R556S	DO23522	LIRI	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.6316
p.S618F	DO222731	MELA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation altering degron motif	0.7982
p.P546S	DO222880	MELA	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.1111
p.E504K	DO222810	MELA	ICGC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation blocking phosphorylation signal	0.6111
p.F500L	DO222837	MELA	ICGC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation rewiring degron network	0.0556
p.I544V	DO228619	PRAD	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.0556
p.N505H	DO36394	READ	ICGC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation rewiring degron network	0.1944
p.S506L	DO38123	SKCM	ICGC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation blocking phosphorylation signal	0.6667
p.R617S	DO229264	THCA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation altering degron motif	0.7427
p.K615E	DO229268	THCA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.3056
p.R632W	DO229250	THCA	ICGC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1111
p.R561K	SIDM00845	Burkitt's Lymphoma	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.7237
p.R561K	SIDM00035	Thyroid Gland Carcinoma	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.7237
p.R561K	SIDM00461	Acute Myeloid Leukemia	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.7237
p.R561K	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.7237
p.R561K	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.7237
p.R561K	DND-41	haematopoietic and lymphoid tissue	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.7237
p.R561K	Daudi	haematopoietic and lymphoid tissue	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation altering degron motif	0.7237
p.I605V	SIDM00845	Burkitt's Lymphoma	GDSC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.25
p.I605V	Daudi	haematopoietic and lymphoid tissue	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.25
p.A607T	SIDM00845	Burkitt's Lymphoma	GDSC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.0833
p.A607T	SIDM00845	Burkitt's Lymphoma	GDSC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1944
p.A607T	Daudi	haematopoietic and lymphoid tissue	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.0833
p.A607T	Daudi	haematopoietic and lymphoid tissue	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1944
p.D633Y	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation substituting flanking lysine	0.1944
p.D633Y	NCI-H810	lung	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation substituting flanking lysine	0.1944
p.S571L	SIDM00392	Melanoma	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.0556
p.S571L	SIDM00392	Melanoma	GDSC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.25
p.S571L	SK-MEL-30	skin	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.0556
p.S571L	SK-MEL-30	skin	COSMIC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.25
p.I507V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	510:514	Mutation rewiring degron network	0.25
p.T609S	SIDM00856	Other Solid Cancers	GDSC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1389
p.T609S	SIDM00856	Other Solid Cancers	GDSC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1389
p.T609S	G-401	soft tissue	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1389
p.T609S	G-401	soft tissue	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1389
p.T566P	SIDM00442	Thyroid Gland Carcinoma	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.1944
p.T566P	SIDM00442	Thyroid Gland Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.T566P	ML-1	thyroid	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.1944
p.T566P	ML-1	thyroid	COSMIC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.P578S	SIDM00210	Ovarian Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.6752
p.P578S	A2780	ovary	COSMIC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.6752
p.V550I	SIDM01188	Pancreatic Carcinoma	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.2222
p.V550I	ACH-000114	Pancreatic Cancer	CCLE	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.2222
p.V550I	SU8686	pancreas	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.2222
p.T589S	SIDM00461	Acute Myeloid Leukemia	GDSC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1667
p.T589S	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1667
p.A624T	SIDM01695	Acute Myeloid Leukemia	GDSC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation altering degron motif	0.7139
p.D625G	SIDM01617	Endometrial Carcinoma	GDSC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.3056
p.A563T	ACH-000166	Leukemia	CCLE	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.2778
p.V610L	ACH-000443	Ovarian Cancer	CCLE	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1667
p.V610L	ACH-000443	Ovarian Cancer	CCLE	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1111
p.V610L	OVKATE	ovary	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.1667
p.V610L	OVKATE	ovary	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.1111
p.P579T	ACH-000631	Brain Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.3056
p.P579T	KS-1	central nervous system	COSMIC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.3056
p.D572Y	ACH-000789	Lung Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2778
p.D572Y	NCI-H810	lung	COSMIC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2778
p.A592P	ACH-000806	Lymphoma	CCLE	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.25
p.A592P	L-540	haematopoietic and lymphoid tissue	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.25
p.D564G	ACH-000994	Endometrial/Uterine Cancer	CCLE	LKRTPHKS	DEG_SCF_FBW7_1	554:561	Mutation rewiring degron network	0.25
p.D564G	ACH-000994	Endometrial/Uterine Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.C581Y	ACH-000999	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.25
p.C581Y	SNU-1040	large intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.25
p.N593S	ACH-001131	Skin Cancer	CCLE	VTATPVLS	DEG_SCF_FBW7_1	595:602	Mutation rewiring degron network	0.2778
p.R613W	ACH-001233	Lung Cancer	CCLE	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.25
p.R613W	VMRC-LCD	lung	COSMIC	RRSYLTPVR	DEG_APCC_DBOX_1	616:624	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R12B

UniProt ID: O60237

Entrez ID: 4660

Protein name: Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP1R12B in