DegronMD

Uniprot ID: O60237

Source protein: Protein phosphatase 1 regulatory subunit 12B

Source gene: PPP1R12B

Class: DEG_SCF_FBW7_1

Location: 554:561

E3 ligase: FBXW7

DEGRON score: 0.9891

ASA_SCORE: 111.0375

COIL: 0.9133

CONS_SCORE: 0.3428

DSS_SCORE: 0.5088

HELIX: 0.06

FCONS_SCORE: 0.9332

RIG_SCORE: 0.7091

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T566I	TCGA-12-1089	GBM	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	0.1944
p.T566I	DO12346	GBM	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	0.1944
p.R556M	TCGA-AP-A051	UCEC	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	0.7521
p.R556M	DO42673	UCEC	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	0.7521
p.E568D	TCGA-AP-A0LM	UCEC	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	0.1389
p.E568D	DO43306	UCEC	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	0.1389
p.K555T	TCGA-AZ-4315	COAD	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	0.6195
p.K555T	DO8842	COAD	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	0.6195
p.D564N	TCGA-BR-8680	STAD	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	0.25
p.D564N	DO233884	GACA	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	0.25
p.D564N	DO47769	STAD	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	0.25
p.S547P	TCGA-E2-A1IF	BRCA	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	0.1389
p.S547P	DO4701	BRCA	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	0.1389
p.S561F	TCGA-FR-A726	SKCM	TCGA	LKRTPHKS	DEG_SCF_FBW7_1	0.9093
p.S561F	DO48665	SKCM	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	0.9093
p.R556S	DO23522	LIRI	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	0.6316
p.P546S	DO222880	MELA	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	0.1111
p.I544V	DO228619	PRAD	ICGC	LKRTPHKS	DEG_SCF_FBW7_1	0.0556
p.R561K	SIDM00845	Burkitt's Lymphoma	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	0.7237
p.R561K	SIDM00035	Thyroid Gland Carcinoma	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	0.7237
p.R561K	SIDM00461	Acute Myeloid Leukemia	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	0.7237
p.R561K	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	0.7237
p.R561K	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	0.7237
p.R561K	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	0.7237
p.R561K	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	0.7237
p.S571L	SIDM00392	Melanoma	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	0.0556
p.S571L	SK-MEL-30	skin	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	0.0556
p.T566P	SIDM00442	Thyroid Gland Carcinoma	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	0.1944
p.T566P	ML-1	thyroid	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	0.1944
p.V550I	SIDM01188	Pancreatic Carcinoma	GDSC	LKRTPHKS	DEG_SCF_FBW7_1	0.2222
p.V550I	ACH-000114	Pancreatic Cancer	CCLE	LKRTPHKS	DEG_SCF_FBW7_1	0.2222
p.V550I	SU8686	pancreas	COSMIC	LKRTPHKS	DEG_SCF_FBW7_1	0.2222
p.A563T	ACH-000166	Leukemia	CCLE	LKRTPHKS	DEG_SCF_FBW7_1	0.2778
p.D564G	ACH-000994	Endometrial/Uterine Cancer	CCLE	LKRTPHKS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKRTPHKS

Degron related mutations and impact score

Drug responses associated with PPP1R12B mutations

All proteins holding degron of LKRTPHKS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_SCF_FBW7_1	554:561	LKRTPHKS	FBXW7	0.9891	More...