DegronMD

Uniprot ID: O60237

Source protein: Protein phosphatase 1 regulatory subunit 12B

Source gene: PPP1R12B

Class: DEG_APCC_KENBOX_2

Location: 510:514

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6136

ASA_SCORE: 114.1

COIL: 0.3

CONS_SCORE: 0.3927

DSS_SCORE: 0.4573

HELIX: 0.6982

FCONS_SCORE: 0.9851

RIG_SCORE: 0.7255

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V518G	TCGA-EE-A3AF	SKCM	TCGA	EKENR	DEG_APCC_KENBOX_2	0.2222
p.V518G	DO37911	SKCM	ICGC	EKENR	DEG_APCC_KENBOX_2	0.2222
p.R500L	TCGA-HJ-7597	STAD	TCGA	EKENR	DEG_APCC_KENBOX_2	0.0556
p.R500L	DO38195	STAD	ICGC	EKENR	DEG_APCC_KENBOX_2	0.0556
p.N513H	DO7801	COAD	ICGC	EKENR	DEG_APCC_KENBOX_2	0.7423
p.F502S	DO14518	HNSC	ICGC	EKENR	DEG_APCC_KENBOX_2	0.1111
p.F502S	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	EKENR	DEG_APCC_KENBOX_2	0.1111
p.F502S	SIDM00781	Colorectal Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	0.1111
p.F502S	HT	haematopoietic_and_lymphoid_tissue	COSMIC	EKENR	DEG_APCC_KENBOX_2	0.1111
p.E504K	DO222810	MELA	ICGC	EKENR	DEG_APCC_KENBOX_2	0.6111
p.F500L	DO222837	MELA	ICGC	EKENR	DEG_APCC_KENBOX_2	0.0556
p.N505H	DO36394	READ	ICGC	EKENR	DEG_APCC_KENBOX_2	0.1944
p.S506L	DO38123	SKCM	ICGC	EKENR	DEG_APCC_KENBOX_2	0.6667
p.I507V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_APCC_KENBOX_2	510:514	EKENR	APC,CDC20,FZR1	0.6136	More...
O75116	Rho-associated protein kinase 2	DEG_APCC_KENBOX_2	1060:1064	EKENR	APC,CDC20,FZR1	0.9504	More...
Q6P444	Mitochondrial fission regulator 2	DEG_APCC_KENBOX_2	330:334	EKENR	APC,CDC20,FZR1	0.9887	More...
Q8NBI3	Draxin	DEG_APCC_KENBOX_2	121:125	EKENR	APC,CDC20,FZR1	0.7139	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons