DegronMD - Q8NBI3(DRAXIN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R60L	TCGA-64-1676	LUAD	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60L	DO23629	LUAD	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R135H	TCGA-AP-A051	UCEC	TCGA	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.0556
p.R135H	DO42673	UCEC	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.0556
p.A116P	TCGA-BR-4361	STAD	TCGA	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.1944
p.A116P	DO38887	STAD	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.1944
p.G46D	TCGA-CN-5367	HNSC	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.G46D	DO15894	HNSC	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R125Q	TCGA-D1-A16X	UCEC	TCGA	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation altering degron motif	0.6218
p.R125Q	DO41799	UCEC	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation altering degron motif	0.6218
p.P62L	TCGA-D7-A4YX	STAD	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1389
p.P62L	DO47997	STAD	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1389
p.A48S	TCGA-DX-A6YS	SARC	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.3056
p.A48S	DO220005	SARC	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.3056
p.N124S	TCGA-DX-A6YS	SARC	TCGA	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation altering degron motif	0.7069
p.N124S	DO220005	SARC	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation altering degron motif	0.7069
p.R58C	TCGA-DY-A1DF	READ	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58C	DO51491	PACA	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58C	DO37058	READ	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58C	SIDM00730	Small Cell Lung Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58C	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58C	NCI-H2227	lung	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.P62Q	TCGA-ER-A198	SKCM	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1389
p.P62Q	DO47563	SKCM	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1389
p.H57R	TCGA-EY-A2OM	UCEC	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.2778
p.H57R	DO43025	UCEC	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.2778
p.A54V	TCGA-FR-A7U9	SKCM	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.5825
p.A54V	DO48546	SKCM	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.5825
p.G114R	TCGA-FR-A8YC	SKCM	TCGA	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.1389
p.G114R	DO50301	SKCM	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.1389
p.P62S	TCGA-FW-A3R5	SKCM	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1389
p.P62S	DO37406	SKCM	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1389
p.P52T	TCGA-IB-7651	PAAD	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7031
p.P52T	DO46657	PAAD	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7031
p.L117F	TCGA-X6-A7WA	SARC	TCGA	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.2222
p.L117F	DO220312	SARC	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.2222
p.R131M	DO233766	GACA	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.1667
p.T51M	DO228929	LICA	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	DO51953	PRAD	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	SIDM00596	Endometrial Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	ACH-000552	Colon/Colorectal Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	ACH-000941	Endometrial/Uterine Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	ACH-000954	Endometrial/Uterine Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	ACH-001517	Endometrial/Uterine Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	ACH-001611	Brain Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	HEC-1	endometrium	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.E39D	DO229008	LICA	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.0556
p.K65T	DO23368	LINC	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation substituting flanking lysine	0.1667
p.R59L	DO228308	MALY	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.2222
p.L112H	DO220876	MELA	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.0833
p.P127S	DO222494	MELA	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.2778
p.P127S	SIDM00362	Burkitt's Lymphoma	GDSC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.2778
p.P127S	ACH-002293	Lymphoma	CCLE	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.2778
p.P127S	P32-ISH	haematopoietic and lymphoid tissue	COSMIC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.2778
p.T132N	DO30060	OV	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation rewiring degron network	0.1389
p.R60W	SIDM00866	Breast Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM01080	Oral Cavity Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM00928	Breast Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM01044	Other Solid Cancers	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM01148	Plasma Cell Myeloma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM01073	Other Blood Cancers	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM00151	Ovarian Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM00778	Colorectal Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM00868	Non-Cancerous	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM01680	Non-Cancerous	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM00929	Chondrosarcoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60W	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R58H	SIDM01034	B-Lymphoblastic Leukemia	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58H	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58H	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58H	SIDM00970	Bladder Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58H	SIDM00591	Oral Cavity Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58H	SIDM01551	Gastric Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58H	SIDM01728	Endometrial Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58H	SIDM01573	Plasma Cell Myeloma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R58H	SIDM01588	Endometrial Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.25
p.R60Q	SIDM00882	Breast Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.R60Q	HCC1419	breast	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation rewiring degron network	0.1944
p.W50C	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.5889
p.W50C	ACH-000888	Lung Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.5889
p.W50C	NCI-H1793	lung	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.5889

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DRAXIN

UniProt ID: Q8NBI3

Entrez ID: 374946

Protein name: Draxin (Dorsal inhibitory axon guidance protein) (Dorsal repulsive axon guidance protein) (Neucrin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DRAXIN in