DegronMD - Q8NBI3(DRAXIN)

FUNCTION: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255|HAMAP-Rule:MF_03060}.

GO - Biological processes (BP): anterior commissure morphogenesis [GO:0021960]; axon guidance [GO:0007411]; commissural neuron differentiation in spinal cord [GO:0021528]; dorsal spinal cord development [GO:0021516]; forebrain development [GO:0030900]; negative regulation of axon extension [GO:0030517]; negative regulation of cano... View more >>

GO - Molecular function (MF):

GO - Cellular component (CC): extracellular region [GO:0005576]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T51M	DO228929	LICA	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	DO51953	PRAD	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	SIDM00596	Endometrial Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	ACH-000552	Colon/Colorectal Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	ACH-000941	Endometrial/Uterine Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	ACH-000954	Endometrial/Uterine Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	ACH-001517	Endometrial/Uterine Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	ACH-001611	Brain Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.T51M	HEC-1	endometrium	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7423
p.N124S	TCGA-DX-A6YS	SARC	TCGA	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation altering degron motif	0.7069
p.N124S	DO220005	SARC	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation altering degron motif	0.7069
p.P52T	TCGA-IB-7651	PAAD	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7031
p.P52T	DO46657	PAAD	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.7031
p.R125Q	TCGA-D1-A16X	UCEC	TCGA	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation altering degron motif	0.6218
p.R125Q	DO41799	UCEC	ICGC	EKENR	DEG_APCC_KENBOX_2	121:125	Mutation altering degron motif	0.6218
p.W50C	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.5889
p.W50C	ACH-000888	Lung Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.5889
p.W50C	NCI-H1793	lung	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.5889
p.A54V	TCGA-FR-A7U9	SKCM	TCGA	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.5825
p.A54V	DO48546	SKCM	ICGC	LWTPQAS	DEG_SCF_FBW7_1	49:55	Mutation altering degron motif	0.5825

Showing 1 to 20 of 83 entries

Previous1 2 3 4 5Next

Kaplan plot for DRAXIN in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DRAXIN

UniProt ID: Q8NBI3

Entrez ID: 374946

Protein name: Draxin (Dorsal inhibitory axon guidance protein) (Dorsal repulsive axon guidance protein) (Neucrin)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DRAXIN in