DegronMD

Uniprot ID: Q8NBI3

Source protein: Draxin

Source gene: DRAXIN

Class: DEG_SCF_FBW7_1

Location: 49:55

E3 ligase: FBXW7

DEGRON score: 0.7468

ASA_SCORE: 78.9286

COIL: 0.8064

CONS_SCORE: 0.5631

DSS_SCORE: 0.6683

HELIX: 0.1666

FCONS_SCORE: 0.9341

RIG_SCORE: 0.6628

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R60L	TCGA-64-1676	LUAD	TCGA	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60L	DO23629	LUAD	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.G46D	TCGA-CN-5367	HNSC	TCGA	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.G46D	DO15894	HNSC	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.P62L	TCGA-D7-A4YX	STAD	TCGA	LWTPQAS	DEG_SCF_FBW7_1	0.1389
p.P62L	DO47997	STAD	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.1389
p.A48S	TCGA-DX-A6YS	SARC	TCGA	LWTPQAS	DEG_SCF_FBW7_1	0.3056
p.A48S	DO220005	SARC	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.3056
p.R58C	TCGA-DY-A1DF	READ	TCGA	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58C	DO51491	PACA	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58C	DO37058	READ	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58C	SIDM00730	Small Cell Lung Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58C	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58C	NCI-H2227	lung	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.P62Q	TCGA-ER-A198	SKCM	TCGA	LWTPQAS	DEG_SCF_FBW7_1	0.1389
p.P62Q	DO47563	SKCM	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.1389
p.H57R	TCGA-EY-A2OM	UCEC	TCGA	LWTPQAS	DEG_SCF_FBW7_1	0.2778
p.H57R	DO43025	UCEC	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.2778
p.A54V	TCGA-FR-A7U9	SKCM	TCGA	LWTPQAS	DEG_SCF_FBW7_1	0.5825
p.A54V	DO48546	SKCM	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.5825
p.P62S	TCGA-FW-A3R5	SKCM	TCGA	LWTPQAS	DEG_SCF_FBW7_1	0.1389
p.P62S	DO37406	SKCM	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.1389
p.P52T	TCGA-IB-7651	PAAD	TCGA	LWTPQAS	DEG_SCF_FBW7_1	0.7031
p.P52T	DO46657	PAAD	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.7031
p.T51M	DO228929	LICA	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.7423
p.T51M	DO51953	PRAD	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.7423
p.T51M	SIDM00596	Endometrial Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.7423
p.T51M	ACH-000552	Colon/Colorectal Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	0.7423
p.T51M	ACH-000941	Endometrial/Uterine Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	0.7423
p.T51M	ACH-000954	Endometrial/Uterine Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	0.7423
p.T51M	ACH-001517	Endometrial/Uterine Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	0.7423
p.T51M	ACH-001611	Brain Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	0.7423
p.T51M	HEC-1	endometrium	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	0.7423
p.E39D	DO229008	LICA	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.0556
p.K65T	DO23368	LINC	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.1667
p.R59L	DO228308	MALY	ICGC	LWTPQAS	DEG_SCF_FBW7_1	0.2222
p.R60W	SIDM00866	Breast Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM01080	Oral Cavity Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM00928	Breast Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM01044	Other Solid Cancers	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM01148	Plasma Cell Myeloma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM01073	Other Blood Cancers	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM00151	Ovarian Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM00778	Colorectal Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM00868	Non-Cancerous	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM01680	Non-Cancerous	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM00929	Chondrosarcoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60W	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R58H	SIDM01034	B-Lymphoblastic Leukemia	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58H	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58H	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58H	SIDM00970	Bladder Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58H	SIDM00591	Oral Cavity Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58H	SIDM01551	Gastric Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58H	SIDM01728	Endometrial Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58H	SIDM01573	Plasma Cell Myeloma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R58H	SIDM01588	Endometrial Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.25
p.R60Q	SIDM00882	Breast Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.R60Q	HCC1419	breast	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	0.1944
p.W50C	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	LWTPQAS	DEG_SCF_FBW7_1	0.5889
p.W50C	ACH-000888	Lung Cancer	CCLE	LWTPQAS	DEG_SCF_FBW7_1	0.5889
p.W50C	NCI-H1793	lung	COSMIC	LWTPQAS	DEG_SCF_FBW7_1	0.5889

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LWTPQAS

Degron related mutations and impact score

Drug responses associated with DRAXIN mutations

All proteins holding degron of LWTPQAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NBI3	Draxin	DEG_SCF_FBW7_1	49:55	LWTPQAS	FBXW7	0.7468	More...