DegronMD

Uniprot ID: Q8NBI3

Source protein: Draxin

Source gene: DRAXIN

Class: DEG_APCC_KENBOX_2

Location: 121:125

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7139

ASA_SCORE: 107.66

COIL: 0.8076

CONS_SCORE: 0.6017

DSS_SCORE: 0.5185

HELIX: 0.1024

FCONS_SCORE: 1.0843

RIG_SCORE: 0.6317

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R135H	TCGA-AP-A051	UCEC	TCGA	EKENR	DEG_APCC_KENBOX_2	0.0556
p.R135H	DO42673	UCEC	ICGC	EKENR	DEG_APCC_KENBOX_2	0.0556
p.A116P	TCGA-BR-4361	STAD	TCGA	EKENR	DEG_APCC_KENBOX_2	0.1944
p.A116P	DO38887	STAD	ICGC	EKENR	DEG_APCC_KENBOX_2	0.1944
p.R125Q	TCGA-D1-A16X	UCEC	TCGA	EKENR	DEG_APCC_KENBOX_2	0.6218
p.R125Q	DO41799	UCEC	ICGC	EKENR	DEG_APCC_KENBOX_2	0.6218
p.N124S	TCGA-DX-A6YS	SARC	TCGA	EKENR	DEG_APCC_KENBOX_2	0.7069
p.N124S	DO220005	SARC	ICGC	EKENR	DEG_APCC_KENBOX_2	0.7069
p.G114R	TCGA-FR-A8YC	SKCM	TCGA	EKENR	DEG_APCC_KENBOX_2	0.1389
p.G114R	DO50301	SKCM	ICGC	EKENR	DEG_APCC_KENBOX_2	0.1389
p.L117F	TCGA-X6-A7WA	SARC	TCGA	EKENR	DEG_APCC_KENBOX_2	0.2222
p.L117F	DO220312	SARC	ICGC	EKENR	DEG_APCC_KENBOX_2	0.2222
p.R131M	DO233766	GACA	ICGC	EKENR	DEG_APCC_KENBOX_2	0.1667
p.L112H	DO220876	MELA	ICGC	EKENR	DEG_APCC_KENBOX_2	0.0833
p.P127S	DO222494	MELA	ICGC	EKENR	DEG_APCC_KENBOX_2	0.2778
p.P127S	SIDM00362	Burkitt's Lymphoma	GDSC	EKENR	DEG_APCC_KENBOX_2	0.2778
p.P127S	ACH-002293	Lymphoma	CCLE	EKENR	DEG_APCC_KENBOX_2	0.2778
p.P127S	P32-ISH	haematopoietic_and_lymphoid_tissue	COSMIC	EKENR	DEG_APCC_KENBOX_2	0.2778
p.T132N	DO30060	OV	ICGC	EKENR	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_APCC_KENBOX_2	510:514	EKENR	APC,CDC20,FZR1	0.6136	More...
O75116	Rho-associated protein kinase 2	DEG_APCC_KENBOX_2	1060:1064	EKENR	APC,CDC20,FZR1	0.9504	More...
Q6P444	Mitochondrial fission regulator 2	DEG_APCC_KENBOX_2	330:334	EKENR	APC,CDC20,FZR1	0.9887	More...
Q8NBI3	Draxin	DEG_APCC_KENBOX_2	121:125	EKENR	APC,CDC20,FZR1	0.7139	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons