DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
EKENR
Uniprot ID:
Q6P444
Source protein:
Mitochondrial fission regulator 2
Source gene:
MTFR2
Class:
DEG_APCC_KENBOX_2
Location:
330:334
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9887
ASA_SCORE:
112.38
COIL:
0.6736
CONS_SCORE:
0.5973
DSS_SCORE:
0.5212
HELIX:
0.301
FCONS_SCORE:
1.0827
RIG_SCORE:
0.6949
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E332D
SIDM00118
Colorectal Carcinoma
GDSC
EKENR
DEG_APCC_KENBOX_2
0.6758
p.E332D
ACH-001081
Colon/Colorectal Cancer
CCLE
EKENR
DEG_APCC_KENBOX_2
0.6758
p.E332D
HCC2998
large_intestine
COSMIC
EKENR
DEG_APCC_KENBOX_2
0.6758
p.K320N
SIDM00118
Colorectal Carcinoma
GDSC
EKENR
DEG_APCC_KENBOX_2
0.5
p.K320N
ACH-001081
Colon/Colorectal Cancer
CCLE
EKENR
DEG_APCC_KENBOX_2
0.5
p.K320N
HCC2998
large_intestine
COSMIC
EKENR
DEG_APCC_KENBOX_2
0.5
p.D326G
TCGA-UY-A78K
BLCA
TCGA
EKENR
DEG_APCC_KENBOX_2
0.2222
p.D326G
DO219031
BLCA
ICGC
EKENR
DEG_APCC_KENBOX_2
0.2222
p.D326G
SIDM01608
Endometrial Carcinoma
GDSC
EKENR
DEG_APCC_KENBOX_2
0.2222
p.D326G
ACH-000990
Endometrial/Uterine Cancer
CCLE
EKENR
DEG_APCC_KENBOX_2
0.2222
p.A322T
TCGA-AA-3977
COAD
TCGA
EKENR
DEG_APCC_KENBOX_2
0.1111
p.A322T
DO8730
COAD
ICGC
EKENR
DEG_APCC_KENBOX_2
0.1111
Showing 1 to 12 of 12 entries
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Drug responses associated with MTFR2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of EKENR
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NBI3
Draxin
DEG_APCC_KENBOX_2
121:125
EKENR
APC,CDC20,FZR1
0.7139
More...
Q6P444
Mitochondrial fission regulator 2
DEG_APCC_KENBOX_2
330:334
EKENR
APC,CDC20,FZR1
0.9887
More...
O60237
Protein phosphatase 1 regulatory subunit 12B
DEG_APCC_KENBOX_2
510:514
EKENR
APC,CDC20,FZR1
0.6136
More...
O75116
Rho-associated protein kinase 2
DEG_APCC_KENBOX_2
1060:1064
EKENR
APC,CDC20,FZR1
0.9504
More...
Showing 1 to 4 of 4 entries
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