DegronMD

Uniprot ID: Q6P444

Source protein: Mitochondrial fission regulator 2

Source gene: MTFR2

Class: DEG_APCC_KENBOX_2

Location: 330:334

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9887

ASA_SCORE: 112.38

COIL: 0.6736

CONS_SCORE: 0.5973

DSS_SCORE: 0.5212

HELIX: 0.301

FCONS_SCORE: 1.0827

RIG_SCORE: 0.6949

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A322T	TCGA-AA-3977	COAD	TCGA	EKENR	DEG_APCC_KENBOX_2	0.1111
p.A322T	DO8730	COAD	ICGC	EKENR	DEG_APCC_KENBOX_2	0.1111
p.D326G	TCGA-UY-A78K	BLCA	TCGA	EKENR	DEG_APCC_KENBOX_2	0.2222
p.D326G	DO219031	BLCA	ICGC	EKENR	DEG_APCC_KENBOX_2	0.2222
p.D326G	SIDM01608	Endometrial Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	0.2222
p.D326G	ACH-000990	Endometrial/Uterine Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	0.2222
p.E332D	SIDM00118	Colorectal Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	0.6758
p.E332D	ACH-001081	Colon/Colorectal Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	0.6758
p.E332D	HCC2998	large_intestine	COSMIC	EKENR	DEG_APCC_KENBOX_2	0.6758
p.K320N	SIDM00118	Colorectal Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	0.5
p.K320N	ACH-001081	Colon/Colorectal Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	0.5
p.K320N	HCC2998	large_intestine	COSMIC	EKENR	DEG_APCC_KENBOX_2	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_APCC_KENBOX_2	510:514	EKENR	APC,CDC20,FZR1	0.6136	More...
O75116	Rho-associated protein kinase 2	DEG_APCC_KENBOX_2	1060:1064	EKENR	APC,CDC20,FZR1	0.9504	More...
Q6P444	Mitochondrial fission regulator 2	DEG_APCC_KENBOX_2	330:334	EKENR	APC,CDC20,FZR1	0.9887	More...
Q8NBI3	Draxin	DEG_APCC_KENBOX_2	121:125	EKENR	APC,CDC20,FZR1	0.7139	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons