DegronMD

Uniprot ID: O75116

Source protein: Rho-associated protein kinase 2

Source gene: ROCK2

Class: DEG_APCC_KENBOX_2

Location: 1060:1064

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9504

ASA_SCORE: 110.62

COIL: 0.0388

CONS_SCORE: 0.5116

DSS_SCORE: 0.5934

HELIX: 0.9626

FCONS_SCORE: 1.1776

RIG_SCORE: 0.6993

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1072C	TCGA-77-6843	LUSC	TCGA	EKENR	DEG_APCC_KENBOX_2	0.1111
p.S1072C	DO27588	LUSC	ICGC	EKENR	DEG_APCC_KENBOX_2	0.1111
p.E1062D	TCGA-AA-A00N	COAD	TCGA	EKENR	DEG_APCC_KENBOX_2	0.6758
p.E1062D	DO224847	BRCA	ICGC	EKENR	DEG_APCC_KENBOX_2	0.6758
p.E1062D	DO227473	BRCA	ICGC	EKENR	DEG_APCC_KENBOX_2	0.6758
p.M1068V	TCGA-DF-A2KN	UCEC	TCGA	EKENR	DEG_APCC_KENBOX_2	0.2222
p.M1068V	DO223282	UCEC	ICGC	EKENR	DEG_APCC_KENBOX_2	0.2222
p.R1074S	DO229029	LICA	ICGC	EKENR	DEG_APCC_KENBOX_2	0.0556
p.I1069V	DO23448	LINC	ICGC	EKENR	DEG_APCC_KENBOX_2	0.1944
p.K1061R	DO229470	SKCA	ICGC	EKENR	DEG_APCC_KENBOX_2	0.7237
p.N1052S	SIDM00845	Burkitt's Lymphoma	GDSC	EKENR	DEG_APCC_KENBOX_2	0.1111
p.N1052S	SIDM01519	Head and Neck Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	0.1111
p.N1052S	ACH-000786	Lymphoma	CCLE	EKENR	DEG_APCC_KENBOX_2	0.1111
p.N1052S	ACH-000992	Head and Neck Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	0.1111
p.R1057W	SIDM00893	Breast Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	0.25
p.R1057W	ACH-000536	Breast Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	0.25
p.R1057W	BT-20	breast	COSMIC	EKENR	DEG_APCC_KENBOX_2	0.25
p.R1057Q	SIDM00363	Acute Myeloid Leukemia	GDSC	EKENR	DEG_APCC_KENBOX_2	0.25
p.R1057Q	ACH-000770	Leukemia	CCLE	EKENR	DEG_APCC_KENBOX_2	0.25
p.R1057Q	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	EKENR	DEG_APCC_KENBOX_2	0.25
p.D1053Y	SIDM01588	Endometrial Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	0.1389
p.D1053Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	0.1389
p.K1064R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	EKENR	DEG_APCC_KENBOX_2	0.7237

Drug responses associated with ROCK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00185	SKCM\|melanoma	p.S1194P (No)	GDSC	GSK269962A	1.1912
SIDM00185	SKCM\|melanoma	p.S1194P (No)	GDSC	GSK429286A	115.1635
SIDM00185	SKCM\|melanoma	p.S1194P (No)	GDSC	WZ3105	9.1043
SIDM00185	SKCM\|melanoma	p.S1194P (No)	GDSC	GSK269962A	54.6441
SIDM00839	COREAD\|large_intestine	p.W138fs*12 (No)	GDSC	GSK429286A	257.4486
SIDM00839	COREAD\|large_intestine	p.W138fs*12 (No)	GDSC	WZ3105	4.3026
SIDM00839	COREAD\|large_intestine	p.W138fs*12 (No)	GDSC	GSK269962A	4.4261
SIDM00839	COREAD\|large_intestine	p.W138fs*12 (No)	GDSC	AZD5363	3.8912
SIDM00572	STAD\|stomach	p.E514K (No)	GDSC	GSK429286A	251.7114
SIDM00572	STAD\|stomach	p.E514K (No)	GDSC	WZ3105	2.4062
SIDM00572	STAD\|stomach	p.E514K (No)	GDSC	GSK269962A	19.3649
SIDM00572	STAD\|stomach	p.E514K (No)	GDSC	AZD5363	76.129
SIDM00688	DLBC\|B_cell_lymphoma	p.R881T (No)	GDSC	GSK429286A	16.2494
SIDM00688	DLBC\|B_cell_lymphoma	p.R881T (No)	GDSC	WZ3105	0.1556
SIDM00688	DLBC\|B_cell_lymphoma	p.R881T (No)	GDSC	AZD5363	6.3004
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.R1380* (No)	GDSC	GSK269962A	13.9107
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.R1380* (No)	GDSC	GSK269962A	16.1349
SIDM00227	NB\|neuroblastoma	p.Q1000H (No)	GDSC	GSK269962A	0.0641
SIDM00227	NB\|neuroblastoma	p.Q1000H (No)	GDSC	GSK429286A	5.8876
SIDM00227	NB\|neuroblastoma	p.Q1000H (No)	GDSC	WZ3105	0.1374
SIDM00227	NB\|neuroblastoma	p.Q1000H (No)	GDSC	GSK269962A	0.0726
SIDM00227	NB\|neuroblastoma	p.Q1000H (No)	GDSC	AZD5363	37.536
SIDM00227	NB\|neuroblastoma	p.G266V (No)	GDSC	GSK269962A	0.0641
SIDM00227	NB\|neuroblastoma	p.G266V (No)	GDSC	GSK429286A	5.8876
SIDM00227	NB\|neuroblastoma	p.G266V (No)	GDSC	WZ3105	0.1374
SIDM00227	NB\|neuroblastoma	p.G266V (No)	GDSC	GSK269962A	0.0726
SIDM00227	NB\|neuroblastoma	p.G266V (No)	GDSC	AZD5363	37.536
SIDM00959	LAML\|acute_myeloid_leukaemia	p.E639D (No)	GDSC	GSK269962A	0.9074
SIDM00959	LAML\|acute_myeloid_leukaemia	p.E639D (No)	GDSC	GSK429286A	14.8445
SIDM00959	LAML\|acute_myeloid_leukaemia	p.E639D (No)	GDSC	WZ3105	0.4498
SIDM00959	LAML\|acute_myeloid_leukaemia	p.E639D (No)	GDSC	GSK269962A	2.9751
SIDM00272	BRCA\|breast	p.E197K (No)	GDSC	GSK429286A	243.0517
SIDM00272	BRCA\|breast	p.E197K (No)	GDSC	WZ3105	0.3136
SIDM00272	BRCA\|breast	p.E197K (No)	GDSC	GSK269962A	11.4947
SIDM00272	BRCA\|breast	p.E197K (No)	GDSC	GSK269962A	4.3991
SIDM00272	BRCA\|breast	p.E197K (No)	GDSC	AZD5363	5.2309
SIDM00214	COREAD\|large_intestine	p.W138fs*31 (No)	GDSC	GSK429286A	114.299
SIDM00214	COREAD\|large_intestine	p.W138fs*31 (No)	GDSC	WZ3105	3.0933
SIDM00214	COREAD\|large_intestine	p.W138fs*31 (No)	GDSC	GSK269962A	0.9948
SIDM00214	COREAD\|large_intestine	p.W138fs*31 (No)	GDSC	AZD5363	12.702
SIDM00781	COREAD\|large_intestine	p.K1308fs*5 (No)	GDSC	GSK429286A	195.0132
SIDM00781	COREAD\|large_intestine	p.K1308fs*5 (No)	GDSC	WZ3105	0.5516
SIDM00781	COREAD\|large_intestine	p.K1308fs*5 (No)	GDSC	GSK269962A	11.8983
SIDM00781	COREAD\|large_intestine	p.K1308fs*5 (No)	GDSC	AZD5363	80.704
SIDM01034	UNCLASSIFIED\|B_cell_leukemia	p.K310N (No)	GDSC	GSK429286A	38.2251
SIDM01034	UNCLASSIFIED\|B_cell_leukemia	p.K310N (No)	GDSC	WZ3105	0.1674
SIDM01034	UNCLASSIFIED\|B_cell_leukemia	p.K310N (No)	GDSC	GSK269962A	3.3341
SIDM01034	UNCLASSIFIED\|B_cell_leukemia	p.K310N (No)	GDSC	AZD5363	6.64
SIDM01162	KIRC\|kidney	p.K471N (No)	GDSC	GSK429286A	37.1664
SIDM01162	KIRC\|kidney	p.K471N (No)	GDSC	WZ3105	14.3148
SIDM01162	KIRC\|kidney	p.K471N (No)	GDSC	GSK269962A	2.9164
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.R491L (No)	GDSC	GSK269962A	15.7631
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.R491L (No)	GDSC	GSK429286A	34.1585
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.R491L (No)	GDSC	WZ3105	19.8766
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.R491L (No)	GDSC	GSK269962A	12.7684
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.R491L (No)	GDSC	AZD5363	24.761
SIDM01007	ALL\|lymphoblastic_leukemia	p.K1307R (No)	GDSC	GSK269962A	1.9027
SIDM01007	ALL\|lymphoblastic_leukemia	p.K1307R (No)	GDSC	GSK429286A	6.7538
SIDM01007	ALL\|lymphoblastic_leukemia	p.K1307R (No)	GDSC	WZ3105	0.0937
SIDM01007	ALL\|lymphoblastic_leukemia	p.K1307R (No)	GDSC	GSK269962A	6.5463
SIDM01007	ALL\|lymphoblastic_leukemia	p.K1307R (No)	GDSC	AZD5363	7.0564
SIDM00781	COREAD\|large_intestine	p.K310N (No)	GDSC	GSK429286A	195.0132
SIDM00781	COREAD\|large_intestine	p.K310N (No)	GDSC	WZ3105	0.5516
SIDM00781	COREAD\|large_intestine	p.K310N (No)	GDSC	GSK269962A	11.8983
SIDM00781	COREAD\|large_intestine	p.K310N (No)	GDSC	AZD5363	80.704
SIDM00980	STAD\|stomach	p.P18Q (No)	GDSC	GSK429286A	214.6125
SIDM00980	STAD\|stomach	p.P18Q (No)	GDSC	WZ3105	1.0423
SIDM00980	STAD\|stomach	p.P18Q (No)	GDSC	GSK269962A	7.8058
SIDM00980	STAD\|stomach	p.P18Q (No)	GDSC	AZD5363	2.7716
SIDM00971	BRCA\|breast	p.E836* (No)	GDSC	GSK269962A	50.5087
SIDM00971	BRCA\|breast	p.E836* (No)	GDSC	GSK269962A	18.442
SIDM00971	BRCA\|breast	p.E836* (No)	GDSC	AZD5363	43.957
SIDM00971	BRCA\|breast	p.E787Q (No)	GDSC	GSK269962A	50.5087
SIDM00971	BRCA\|breast	p.E787Q (No)	GDSC	GSK269962A	18.442
SIDM00971	BRCA\|breast	p.E787Q (No)	GDSC	AZD5363	43.957
SIDM00971	BRCA\|breast	p.L543F (No)	GDSC	GSK269962A	50.5087
SIDM00971	BRCA\|breast	p.L543F (No)	GDSC	GSK269962A	18.442
SIDM00971	BRCA\|breast	p.L543F (No)	GDSC	AZD5363	43.957
SIDM00971	BRCA\|breast	p.E541* (No)	GDSC	GSK269962A	50.5087
SIDM00971	BRCA\|breast	p.E541* (No)	GDSC	GSK269962A	18.442
SIDM00971	BRCA\|breast	p.E541* (No)	GDSC	AZD5363	43.957
SIDM00214	COREAD\|large_intestine	p.R1380* (No)	GDSC	GSK429286A	114.299
SIDM00214	COREAD\|large_intestine	p.R1380* (No)	GDSC	WZ3105	3.0933
SIDM00214	COREAD\|large_intestine	p.R1380* (No)	GDSC	GSK269962A	0.9948
SIDM00214	COREAD\|large_intestine	p.R1380* (No)	GDSC	AZD5363	12.702
SIDM00175	SKCM\|melanoma	p.Y1174fs*7 (No)	GDSC	GSK429286A	200.53
SIDM00175	SKCM\|melanoma	p.Y1174fs*7 (No)	GDSC	WZ3105	6.3067
SIDM00175	SKCM\|melanoma	p.Y1174fs*7 (No)	GDSC	GSK269962A	13.0364
SIDM01088	UNCLASSIFIED\|endometrium	p.A1013T (No)	GDSC	GSK269962A	7.4197
SIDM01088	UNCLASSIFIED\|endometrium	p.A1013T (No)	GDSC	GSK429286A	167.9332
SIDM01088	UNCLASSIFIED\|endometrium	p.A1013T (No)	GDSC	WZ3105	1.6912
SIDM01088	UNCLASSIFIED\|endometrium	p.A1013T (No)	GDSC	GSK269962A	5.1945
SIDM01088	UNCLASSIFIED\|endometrium	p.A1013T (No)	GDSC	AZD5363	1.1696
SIDM00101	MESO\|mesothelioma	p.I1298_H1301delIKCH (No)	GDSC	GSK429286A	109.1258
SIDM00101	MESO\|mesothelioma	p.I1298_H1301delIKCH (No)	GDSC	WZ3105	0.9477
SIDM00101	MESO\|mesothelioma	p.I1298_H1301delIKCH (No)	GDSC	GSK269962A	14.2554
SIDM00101	MESO\|mesothelioma	p.I1298_H1301delIKCH (No)	GDSC	AZD5363	147.56
SIDM00187	KIRC\|kidney	p.A145T (No)	GDSC	GSK269962A	7.4872
SIDM00187	KIRC\|kidney	p.A145T (No)	GDSC	GSK429286A	175.8682
SIDM00187	KIRC\|kidney	p.A145T (No)	GDSC	WZ3105	23.5843
SIDM00187	KIRC\|kidney	p.A145T (No)	GDSC	GSK269962A	3.6011
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.S457N (No)	GDSC	GSK429286A	19.5631
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.S457N (No)	GDSC	WZ3105	0.7645
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.S457N (No)	GDSC	GSK269962A	2.6514
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.S457N (No)	GDSC	AZD5363	98.033
SIDM00156	NB\|neuroblastoma	p.E320Q (No)	GDSC	GSK269962A	11.098
SIDM00156	NB\|neuroblastoma	p.E320Q (No)	GDSC	GSK429286A	159.561
SIDM00156	NB\|neuroblastoma	p.E320Q (No)	GDSC	WZ3105	0.452
SIDM00156	NB\|neuroblastoma	p.E320Q (No)	GDSC	GSK269962A	11.138
SIDM00156	NB\|neuroblastoma	p.E320Q (No)	GDSC	AZD5363	45.829
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R1377Q (No)	GDSC	GSK429286A	120.711
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R1377Q (No)	GDSC	WZ3105	0.696
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R1377Q (No)	GDSC	GSK269962A	1.7768
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R1377Q (No)	GDSC	AZD5363	37.363
SIDM00946	ALL\|T_cell_leukemia	p.T1323A (No)	GDSC	GSK269962A	8.02
SIDM00946	ALL\|T_cell_leukemia	p.T1323A (No)	GDSC	GSK429286A	21.5441
SIDM00946	ALL\|T_cell_leukemia	p.T1323A (No)	GDSC	WZ3105	0.3785
SIDM00946	ALL\|T_cell_leukemia	p.T1323A (No)	GDSC	GSK269962A	3.5338
SIDM00946	ALL\|T_cell_leukemia	p.T1323A (No)	GDSC	AZD5363	37.737
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.K310N (No)	GDSC	GSK429286A	24.3089
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.K310N (No)	GDSC	WZ3105	0.1728
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.K310N (No)	GDSC	GSK269962A	4.7298
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.K310N (No)	GDSC	AZD5363	7.8033
SIDM01059	SKCM\|melanoma	p.A710V (No)	GDSC	GSK429286A	196.802
SIDM01059	SKCM\|melanoma	p.A710V (No)	GDSC	WZ3105	1.0505
SIDM01059	SKCM\|melanoma	p.A710V (No)	GDSC	GSK269962A	8.2921
SIDM00129	SKCM\|melanoma	p.A196V (No)	GDSC	GSK429286A	61.8175
SIDM00129	SKCM\|melanoma	p.A196V (No)	GDSC	WZ3105	1.4833
SIDM00129	SKCM\|melanoma	p.A196V (No)	GDSC	GSK269962A	2.6367
SIDM00999	BLCA\|bladder	p.Y194C (No)	GDSC	GSK429286A	78.4958
SIDM00999	BLCA\|bladder	p.Y194C (No)	GDSC	WZ3105	0.8258
SIDM00999	BLCA\|bladder	p.Y194C (No)	GDSC	GSK269962A	5.9472
SIDM00999	BLCA\|bladder	p.Y194C (No)	GDSC	AZD5363	21.897
SIDM00217	COREAD\|large_intestine	p.T967I (No)	GDSC	GSK429286A	167.3896
SIDM00217	COREAD\|large_intestine	p.T967I (No)	GDSC	WZ3105	0.1618
SIDM00217	COREAD\|large_intestine	p.T967I (No)	GDSC	GSK269962A	26.5742
SIDM00893	BRCA\|breast	p.R1057W (Yes)	GDSC	GSK429286A	472.7388
SIDM00893	BRCA\|breast	p.R1057W (Yes)	GDSC	WZ3105	1.6502
SIDM00893	BRCA\|breast	p.R1057W (Yes)	GDSC	GSK269962A	85.1789
SIDM00893	BRCA\|breast	p.R1057W (Yes)	GDSC	GSK269962A	13.506
SIDM00893	BRCA\|breast	p.R1057W (Yes)	GDSC	AZD5363	3.9796
SIDM00893	BRCA\|breast	p.Y166D (No)	GDSC	GSK429286A	472.7388
SIDM00893	BRCA\|breast	p.Y166D (No)	GDSC	WZ3105	1.6502
SIDM00893	BRCA\|breast	p.Y166D (No)	GDSC	GSK269962A	85.1789
SIDM00893	BRCA\|breast	p.Y166D (No)	GDSC	GSK269962A	13.506
SIDM00893	BRCA\|breast	p.Y166D (No)	GDSC	AZD5363	3.9796
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1147A (No)	GDSC	GSK269962A	9.432
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1147A (No)	GDSC	GSK429286A	204.9826
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1147A (No)	GDSC	WZ3105	0.3876
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1147A (No)	GDSC	GSK269962A	7.2023
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1147A (No)	GDSC	AZD5363	18.371
SIDM00082	SKCM\|melanoma	p.N622S (No)	GDSC	GSK269962A	21.1804
SIDM00082	SKCM\|melanoma	p.N622S (No)	GDSC	GSK429286A	66.6875
SIDM00082	SKCM\|melanoma	p.N622S (No)	GDSC	WZ3105	0.5048
SIDM00082	SKCM\|melanoma	p.N622S (No)	GDSC	GSK269962A	16.1085
SIDM00082	SKCM\|melanoma	p.N622S (No)	GDSC	AZD5363	86.97
SIDM01042	BRCA\|breast	p.G49D (No)	GDSC	GSK269962A	20.7766
SIDM01042	BRCA\|breast	p.G49D (No)	GDSC	GSK429286A	192.9463
SIDM01042	BRCA\|breast	p.G49D (No)	GDSC	WZ3105	0.7461
SIDM01042	BRCA\|breast	p.G49D (No)	GDSC	GSK269962A	7.5639
SIDM01042	BRCA\|breast	p.G49D (No)	GDSC	GSK269962A	7.8097
SIDM01042	BRCA\|breast	p.G49D (No)	GDSC	AZD5363	0.2825
SIDM00839	COREAD\|large_intestine	p.D1110N (No)	GDSC	GSK429286A	257.4486
SIDM00839	COREAD\|large_intestine	p.D1110N (No)	GDSC	WZ3105	4.3026
SIDM00839	COREAD\|large_intestine	p.D1110N (No)	GDSC	GSK269962A	4.4261
SIDM00839	COREAD\|large_intestine	p.D1110N (No)	GDSC	AZD5363	3.8912
SIDM01141	OV\|ovary	p.A663T (No)	GDSC	GSK429286A	278.3911
SIDM01141	OV\|ovary	p.A663T (No)	GDSC	WZ3105	0.9709
SIDM01141	OV\|ovary	p.A663T (No)	GDSC	GSK269962A	17.2857
SIDM01141	OV\|ovary	p.A663T (No)	GDSC	AZD5363	40.022
SIDM00216	COREAD\|large_intestine	p.S381N (No)	GDSC	GSK429286A	173.174
SIDM00216	COREAD\|large_intestine	p.S381N (No)	GDSC	WZ3105	0.1819
SIDM00216	COREAD\|large_intestine	p.S381N (No)	GDSC	AZD5363	22.042
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.T1026I (No)	GDSC	GSK429286A	347.4765
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.T1026I (No)	GDSC	WZ3105	0.193
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.T1026I (No)	GDSC	GSK269962A	34.2822
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.T1026I (No)	GDSC	AZD5363	3.4142
SIDM00282	COREAD\|large_intestine	p.P1248S (No)	GDSC	GSK269962A	43.0734
SIDM00282	COREAD\|large_intestine	p.P1248S (No)	GDSC	GSK429286A	150.6915
SIDM00282	COREAD\|large_intestine	p.P1248S (No)	GDSC	WZ3105	68.4683
SIDM00282	COREAD\|large_intestine	p.P1248S (No)	GDSC	GSK269962A	13.4125
SIDM00282	COREAD\|large_intestine	p.P1248S (No)	GDSC	AZD5363	48.594
SIDM01088	UNCLASSIFIED\|endometrium	p.M822fs*6 (No)	GDSC	GSK269962A	7.4197
SIDM01088	UNCLASSIFIED\|endometrium	p.M822fs*6 (No)	GDSC	GSK429286A	167.9332
SIDM01088	UNCLASSIFIED\|endometrium	p.M822fs*6 (No)	GDSC	WZ3105	1.6912
SIDM01088	UNCLASSIFIED\|endometrium	p.M822fs*6 (No)	GDSC	GSK269962A	5.1945
SIDM01088	UNCLASSIFIED\|endometrium	p.M822fs*6 (No)	GDSC	AZD5363	1.1696
SIDM00220	OV\|ovary	p.W138fs*31 (No)	GDSC	GSK429286A	35.2208
SIDM00220	OV\|ovary	p.W138fs*31 (No)	GDSC	WZ3105	0.3011
SIDM00220	OV\|ovary	p.W138fs*31 (No)	GDSC	GSK269962A	2.7279
SIDM00220	OV\|ovary	p.W138fs*31 (No)	GDSC	AZD5363	10.066
SIDM00363	LAML\|acute_myeloid_leukaemia	p.R1057Q (Yes)	GDSC	GSK269962A	16.9159
SIDM00363	LAML\|acute_myeloid_leukaemia	p.R1057Q (Yes)	GDSC	GSK429286A	68.8145
SIDM00363	LAML\|acute_myeloid_leukaemia	p.R1057Q (Yes)	GDSC	WZ3105	1.5488
SIDM00363	LAML\|acute_myeloid_leukaemia	p.R1057Q (Yes)	GDSC	GSK269962A	0.0399
SIDM00363	LAML\|acute_myeloid_leukaemia	p.R1057Q (Yes)	GDSC	AZD5363	5.1592
SIDM00128	HNSC\|head_and_neck	p.D601V (No)	GDSC	GSK429286A	150.1778
SIDM00128	HNSC\|head_and_neck	p.D601V (No)	GDSC	WZ3105	0.3456
SIDM00128	HNSC\|head_and_neck	p.D601V (No)	GDSC	GSK269962A	20.54
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q798H (No)	GDSC	GSK269962A	5.7854
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q798H (No)	GDSC	GSK429286A	41.8291
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q798H (No)	GDSC	WZ3105	0.1976
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q798H (No)	GDSC	GSK269962A	29.8337
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q798H (No)	GDSC	AZD5363	10.941
SIDM00534	COREAD\|large_intestine	p.K1325N (No)	GDSC	GSK429286A	93.4991
SIDM00534	COREAD\|large_intestine	p.K1325N (No)	GDSC	WZ3105	12.498
SIDM00534	COREAD\|large_intestine	p.K1325N (No)	GDSC	GSK269962A	2.1446
SIDM00217	COREAD\|large_intestine	p.N65fs*4 (No)	GDSC	GSK429286A	167.3896
SIDM00217	COREAD\|large_intestine	p.N65fs*4 (No)	GDSC	WZ3105	0.1618
SIDM00217	COREAD\|large_intestine	p.N65fs*4 (No)	GDSC	GSK269962A	26.5742
SIDM01112	UNCLASSIFIED\|bone_other	p.V1048I (No)	GDSC	GSK269962A	2.3992
SIDM01112	UNCLASSIFIED\|bone_other	p.V1048I (No)	GDSC	GSK429286A	226.594
SIDM01112	UNCLASSIFIED\|bone_other	p.V1048I (No)	GDSC	WZ3105	0.7342
SIDM01112	UNCLASSIFIED\|bone_other	p.V1048I (No)	GDSC	GSK269962A	14.6522
SIDM01112	UNCLASSIFIED\|bone_other	p.V1048I (No)	GDSC	AZD5363	10.777
SIDM00120	PRAD\|prostate	p.V215L (No)	GDSC	GSK429286A	242.1882
SIDM00120	PRAD\|prostate	p.V215L (No)	GDSC	WZ3105	5.5969
SIDM00120	PRAD\|prostate	p.V215L (No)	GDSC	GSK269962A	3.2789
SIDM00120	PRAD\|prostate	p.V215L (No)	GDSC	AZD5363	37.208
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E942Q (No)	GDSC	GSK429286A	266.9702
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E942Q (No)	GDSC	WZ3105	40.7427
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E942Q (No)	GDSC	GSK269962A	10.7183
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E942Q (No)	GDSC	AZD5363	27.517
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.M736I (No)	GDSC	GSK429286A	266.9702
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.M736I (No)	GDSC	WZ3105	40.7427
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.M736I (No)	GDSC	GSK269962A	10.7183
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.M736I (No)	GDSC	AZD5363	27.517
SIDM00614	LIHC\|liver	p.H1258fs*21 (No)	GDSC	GSK429286A	140.6985
SIDM00614	LIHC\|liver	p.H1258fs*21 (No)	GDSC	WZ3105	17.064
SIDM00614	LIHC\|liver	p.H1258fs*21 (No)	GDSC	GSK269962A	2.3784
SIDM00614	LIHC\|liver	p.H1258fs*21 (No)	GDSC	AZD5363	125.04
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D854V (No)	GDSC	GSK429286A	107.4332
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D854V (No)	GDSC	WZ3105	23.2143
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D854V (No)	GDSC	GSK269962A	4.277
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.M859I (No)	GDSC	GSK269962A	5.5119
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.M859I (No)	GDSC	GSK429286A	112.3642
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.M859I (No)	GDSC	WZ3105	9.4683
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.M859I (No)	GDSC	GSK269962A	5.8056
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.M859I (No)	GDSC	AZD5363	68.521
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P1357H (No)	GDSC	GSK269962A	4.6059
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P1357H (No)	GDSC	GSK429286A	205.3761
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P1357H (No)	GDSC	WZ3105	1.6705
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P1357H (No)	GDSC	GSK269962A	5.3021
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P1357H (No)	GDSC	AZD5363	36.393
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G267D (No)	GDSC	GSK429286A	107.836
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G267D (No)	GDSC	WZ3105	0.0826
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G267D (No)	GDSC	GSK269962A	32.5445
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G267D (No)	GDSC	AZD5363	8.1443
SIDM00120	PRAD\|prostate	p.R546fs*10 (No)	GDSC	GSK429286A	242.1882
SIDM00120	PRAD\|prostate	p.R546fs*10 (No)	GDSC	WZ3105	5.5969
SIDM00120	PRAD\|prostate	p.R546fs*10 (No)	GDSC	GSK269962A	3.2789
SIDM00120	PRAD\|prostate	p.R546fs*10 (No)	GDSC	AZD5363	37.208
SIDM00374	DLBC\|B_cell_lymphoma	p.T1323M (No)	GDSC	GSK269962A	5.9895
SIDM00374	DLBC\|B_cell_lymphoma	p.T1323M (No)	GDSC	GSK429286A	34.6294
SIDM00374	DLBC\|B_cell_lymphoma	p.T1323M (No)	GDSC	WZ3105	0.0637
SIDM00374	DLBC\|B_cell_lymphoma	p.T1323M (No)	GDSC	GSK269962A	10.814
SIDM00374	DLBC\|B_cell_lymphoma	p.T1323M (No)	GDSC	AZD5363	7.4283
SIDM00900	MM\|myeloma	p.M953I (No)	GDSC	GSK269962A	23.2778
SIDM00900	MM\|myeloma	p.M953I (No)	GDSC	GSK429286A	104.2093
SIDM00900	MM\|myeloma	p.M953I (No)	GDSC	WZ3105	0.4563
SIDM00900	MM\|myeloma	p.M953I (No)	GDSC	GSK269962A	15.1307
SIDM00900	MM\|myeloma	p.M953I (No)	GDSC	AZD5363	2.9808
SIDM00193	COREAD\|large_intestine	p.R1044Q (No)	GDSC	GSK429286A	493.6422
SIDM00193	COREAD\|large_intestine	p.R1044Q (No)	GDSC	WZ3105	0.4941
SIDM00193	COREAD\|large_intestine	p.R1044Q (No)	GDSC	GSK269962A	19.609
SIDM00193	COREAD\|large_intestine	p.E430* (No)	GDSC	GSK429286A	493.6422
SIDM00193	COREAD\|large_intestine	p.E430* (No)	GDSC	WZ3105	0.4941
SIDM00193	COREAD\|large_intestine	p.E430* (No)	GDSC	GSK269962A	19.609
SIDM00193	COREAD\|large_intestine	p.K326N (No)	GDSC	GSK429286A	493.6422
SIDM00193	COREAD\|large_intestine	p.K326N (No)	GDSC	WZ3105	0.4941
SIDM00193	COREAD\|large_intestine	p.K326N (No)	GDSC	GSK269962A	19.609
SIDM00193	COREAD\|large_intestine	p.R273Q (No)	GDSC	GSK429286A	493.6422
SIDM00193	COREAD\|large_intestine	p.R273Q (No)	GDSC	WZ3105	0.4941
SIDM00193	COREAD\|large_intestine	p.R273Q (No)	GDSC	GSK269962A	19.609
SIDM00193	COREAD\|large_intestine	p.D142Y (No)	GDSC	GSK429286A	493.6422
SIDM00193	COREAD\|large_intestine	p.D142Y (No)	GDSC	WZ3105	0.4941
SIDM00193	COREAD\|large_intestine	p.D142Y (No)	GDSC	GSK269962A	19.609
SIDM00118	COREAD\|large_intestine	p.K941N (No)	GDSC	GSK269962A	11.5528
SIDM00118	COREAD\|large_intestine	p.K941N (No)	GDSC	GSK429286A	225.5816
SIDM00118	COREAD\|large_intestine	p.K941N (No)	GDSC	WZ3105	0.4527
SIDM00118	COREAD\|large_intestine	p.K941N (No)	GDSC	GSK269962A	56.652
SIDM00118	COREAD\|large_intestine	p.K941N (No)	GDSC	AZD5363	5.9152
SIDM00118	COREAD\|large_intestine	p.D385N (No)	GDSC	GSK269962A	11.5528
SIDM00118	COREAD\|large_intestine	p.D385N (No)	GDSC	GSK429286A	225.5816
SIDM00118	COREAD\|large_intestine	p.D385N (No)	GDSC	WZ3105	0.4527
SIDM00118	COREAD\|large_intestine	p.D385N (No)	GDSC	GSK269962A	56.652
SIDM00118	COREAD\|large_intestine	p.D385N (No)	GDSC	AZD5363	5.9152
SIDM00118	COREAD\|large_intestine	p.N327T (No)	GDSC	GSK269962A	11.5528
SIDM00118	COREAD\|large_intestine	p.N327T (No)	GDSC	GSK429286A	225.5816
SIDM00118	COREAD\|large_intestine	p.N327T (No)	GDSC	WZ3105	0.4527
SIDM00118	COREAD\|large_intestine	p.N327T (No)	GDSC	GSK269962A	56.652
SIDM00118	COREAD\|large_intestine	p.N327T (No)	GDSC	AZD5363	5.9152
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.R476L (No)	GDSC	GSK269962A	1.4697
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.R476L (No)	GDSC	GSK429286A	97.6391
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.R476L (No)	GDSC	WZ3105	0.7926
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.R476L (No)	GDSC	GSK269962A	1.9187

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_APCC_KENBOX_2	510:514	EKENR	APC,CDC20,FZR1	0.6136	More...
O75116	Rho-associated protein kinase 2	DEG_APCC_KENBOX_2	1060:1064	EKENR	APC,CDC20,FZR1	0.9504	More...
Q6P444	Mitochondrial fission regulator 2	DEG_APCC_KENBOX_2	330:334	EKENR	APC,CDC20,FZR1	0.9887	More...
Q8NBI3	Draxin	DEG_APCC_KENBOX_2	121:125	EKENR	APC,CDC20,FZR1	0.7139	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EKENR

Degron related mutations and impact score

Drug responses associated with ROCK2 mutations

All proteins holding degron of EKENR