DegronMD - O75116(ROCK2)

GO - Biological processes (BP): actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; aortic valve morphogenesis [GO:0003180]; blood vessel diameter maintenance [GO:0097746]; cellular response to acetylcholine [GO:1905145]; cellular response to testosterone stimulus [GO:0071394]; centrosome duplication [GO:0051298]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; mitotic cytokinesis [GO:0000281]; mRNA destabilization [GO:0061157]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of gene expression [GO:0010629]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein localization to lysosome [GO:0150033]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell migration [GO:0030335]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of connective tissue growth factor production [GO:0032723]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of cell adhesion [GO:0030155]; regulation of cell junction assembly [GO:1901888]; regulation of cell motility [GO:2000145]; regulation of cellular response to hypoxia [GO:1900037]; regulation of circadian rhythm [GO:0042752]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of nervous system process [GO:0031644]; regulation of protein metabolic process [GO:0051246]; regulation of stress fiber assembly [GO:0051492]; response to angiotensin [GO:1990776]; response to ischemia [GO:0002931]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; rhythmic process [GO:0048511]; smooth muscle contraction [GO:0006939]; viral RNA genome replication [GO:0039694] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1072C	TCGA-77-6843	LUSC	TCGA	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.1111
p.S1072C	DO27588	LUSC	ICGC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.1111
p.E1062D	TCGA-AA-A00N	COAD	TCGA	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation altering degron motif	0.6758
p.E1062D	DO224847	BRCA	ICGC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation altering degron motif	0.6758
p.E1062D	DO227473	BRCA	ICGC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation altering degron motif	0.6758
p.M1068V	TCGA-DF-A2KN	UCEC	TCGA	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.2222
p.M1068V	DO223282	UCEC	ICGC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.2222
p.R1074S	DO229029	LICA	ICGC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.0556
p.I1069V	DO23448	LINC	ICGC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.1944
p.K1061R	DO229470	SKCA	ICGC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation altering degron motif	0.7237
p.N1052S	SIDM00845	Burkitt's Lymphoma	GDSC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.1111
p.N1052S	SIDM01519	Head and Neck Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.1111
p.N1052S	ACH-000786	Lymphoma	CCLE	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.1111
p.N1052S	ACH-000992	Head and Neck Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.1111
p.R1057W	SIDM00893	Breast Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.25
p.R1057W	ACH-000536	Breast Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.25
p.R1057W	BT-20	breast	COSMIC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.25
p.R1057Q	SIDM00363	Acute Myeloid Leukemia	GDSC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.25
p.R1057Q	ACH-000770	Leukemia	CCLE	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.25
p.R1057Q	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.25
p.D1053Y	SIDM01588	Endometrial Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.1389
p.D1053Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation rewiring degron network	0.1389
p.K1064R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	EKENR	DEG_APCC_KENBOX_2	1060:1064	Mutation altering degron motif	0.7237

Kaplan plot for ROCK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ROCK2

UniProt ID: O75116

Entrez ID: 9475

Protein name: Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ROCK2 in