DegronMD - Q6P444(MTFR2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R180H	TCGA-A6-6781	COAD	TCGA	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.8244
p.R180H	DO8858	COAD	ICGC	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.8244
p.R180H	DO8447	COAD	ICGC	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.8244
p.R180H	SIDM00602	Gastric Carcinoma	GDSC	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.8244
p.R180H	ACH-000919	Gastric Cancer	CCLE	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.8244
p.R180H	IM-95	stomach	COSMIC	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.8244
p.A322T	TCGA-AA-3977	COAD	TCGA	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation rewiring degron network	0.1111
p.A322T	DO8730	COAD	ICGC	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation rewiring degron network	0.1111
p.S188P	TCGA-B5-A0K6	UCEC	TCGA	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.3056
p.S188P	DO40808	UCEC	ICGC	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.3056
p.D326G	TCGA-UY-A78K	BLCA	TCGA	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation rewiring degron network	0.2222
p.D326G	DO219031	BLCA	ICGC	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation rewiring degron network	0.2222
p.D326G	SIDM01608	Endometrial Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation rewiring degron network	0.2222
p.D326G	ACH-000990	Endometrial/Uterine Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation rewiring degron network	0.2222
p.S195T	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1111
p.S195T	ACH-000893	Lung Cancer	CCLE	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1111
p.S195T	NCI-H1651	lung	COSMIC	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1111
p.E179K	SIDM00534	Colorectal Carcinoma	GDSC	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.591
p.E332D	SIDM00118	Colorectal Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation altering degron motif	0.6758
p.E332D	ACH-001081	Colon/Colorectal Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation altering degron motif	0.6758
p.E332D	HCC2998	large intestine	COSMIC	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation altering degron motif	0.6758
p.K320N	SIDM00118	Colorectal Carcinoma	GDSC	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation blocking ubiquitination signal	0.5
p.K320N	ACH-001081	Colon/Colorectal Cancer	CCLE	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation blocking ubiquitination signal	0.5
p.K320N	HCC2998	large intestine	COSMIC	EKENR	DEG_APCC_KENBOX_2	330:334	Mutation blocking ubiquitination signal	0.5
p.S187L	ACH-000503	Head and Neck Cancer	CCLE	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.6556
p.S187T	ACH-001414	Bladder Cancer	CCLE	ERISLGQLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.6005

Kaplan plot for MTFR2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTFR2

UniProt ID: Q6P444

Entrez ID: 113115

Protein name: Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTFR2 in