DegronMD

Uniprot ID: Q6P444

Source protein: Mitochondrial fission regulator 2

Source gene: MTFR2

Class: DEG_APCC_DBOX_1

Location: 179:187

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9257

ASA_SCORE: 77.3111

COIL: 0.7482

CONS_SCORE: 0.2411

DSS_SCORE: 0.4136

HELIX: 0.1574

FCONS_SCORE: 0.9006

RIG_SCORE: 0.6872

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R180H	TCGA-A6-6781	COAD	TCGA	ERISLGQLS	DEG_APCC_DBOX_1	0.8244
p.R180H	DO8858	COAD	ICGC	ERISLGQLS	DEG_APCC_DBOX_1	0.8244
p.R180H	DO8447	COAD	ICGC	ERISLGQLS	DEG_APCC_DBOX_1	0.8244
p.R180H	SIDM00602	Gastric Carcinoma	GDSC	ERISLGQLS	DEG_APCC_DBOX_1	0.8244
p.R180H	ACH-000919	Gastric Cancer	CCLE	ERISLGQLS	DEG_APCC_DBOX_1	0.8244
p.R180H	IM-95	stomach	COSMIC	ERISLGQLS	DEG_APCC_DBOX_1	0.8244
p.S188P	TCGA-B5-A0K6	UCEC	TCGA	ERISLGQLS	DEG_APCC_DBOX_1	0.3056
p.S188P	DO40808	UCEC	ICGC	ERISLGQLS	DEG_APCC_DBOX_1	0.3056
p.S195T	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	ERISLGQLS	DEG_APCC_DBOX_1	0.1111
p.S195T	ACH-000893	Lung Cancer	CCLE	ERISLGQLS	DEG_APCC_DBOX_1	0.1111
p.S195T	NCI-H1651	lung	COSMIC	ERISLGQLS	DEG_APCC_DBOX_1	0.1111
p.E179K	SIDM00534	Colorectal Carcinoma	GDSC	ERISLGQLS	DEG_APCC_DBOX_1	0.591
p.S187L	ACH-000503	Head and Neck Cancer	CCLE	ERISLGQLS	DEG_APCC_DBOX_1	0.6556
p.S187T	ACH-001414	Bladder Cancer	CCLE	ERISLGQLS	DEG_APCC_DBOX_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P444	Mitochondrial fission regulator 2	DEG_APCC_DBOX_1	179:187	ERISLGQLS	APC,CDC20,FZR1	0.9257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons