DegronMD

Uniprot ID: O60237

Source protein: Protein phosphatase 1 regulatory subunit 12B

Source gene: PPP1R12B

Class: DEG_SCF_FBW7_1

Location: 595:602

E3 ligase: FBXW7

DEGRON score: 0.9888

ASA_SCORE: 81.2

COIL: 0.8548

CONS_SCORE: 0.4042

DSS_SCORE: 0.4766

HELIX: 0.0201

FCONS_SCORE: 1.0709

RIG_SCORE: 0.765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G594R	TCGA-19-1790	GBM	TCGA	VTATPVLS	DEG_SCF_FBW7_1	0.3056
p.G594R	DO12328	GBM	ICGC	VTATPVLS	DEG_SCF_FBW7_1	0.3056
p.L588F	TCGA-55-7911	LUAD	TCGA	VTATPVLS	DEG_SCF_FBW7_1	0.1389
p.L588F	TCGA-DS-A0VM	CESC	TCGA	VTATPVLS	DEG_SCF_FBW7_1	0.1389
p.L588F	DO6258	CESC	ICGC	VTATPVLS	DEG_SCF_FBW7_1	0.1389
p.L588F	DO24821	LUAD	ICGC	VTATPVLS	DEG_SCF_FBW7_1	0.1389
p.R586H	TCGA-AA-3842	COAD	TCGA	VTATPVLS	DEG_SCF_FBW7_1	0.0833
p.R586H	TCGA-BR-4184	STAD	TCGA	VTATPVLS	DEG_SCF_FBW7_1	0.0833
p.R586H	DO9394	COAD	ICGC	VTATPVLS	DEG_SCF_FBW7_1	0.0833
p.R586H	DO38328	STAD	ICGC	VTATPVLS	DEG_SCF_FBW7_1	0.0833
p.L601F	DO229003	COCA	ICGC	VTATPVLS	DEG_SCF_FBW7_1	0.587
p.A592D	DO229036	LICA	ICGC	VTATPVLS	DEG_SCF_FBW7_1	0.25
p.I605V	SIDM00845	Burkitt's Lymphoma	GDSC	VTATPVLS	DEG_SCF_FBW7_1	0.25
p.I605V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	0.25
p.A607T	SIDM00845	Burkitt's Lymphoma	GDSC	VTATPVLS	DEG_SCF_FBW7_1	0.1944
p.A607T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	0.1944
p.T609S	SIDM00856	Other Solid Cancers	GDSC	VTATPVLS	DEG_SCF_FBW7_1	0.1389
p.T609S	G-401	soft_tissue	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	0.1389
p.T589S	SIDM00461	Acute Myeloid Leukemia	GDSC	VTATPVLS	DEG_SCF_FBW7_1	0.1667
p.T589S	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	0.1667
p.V610L	ACH-000443	Ovarian Cancer	CCLE	VTATPVLS	DEG_SCF_FBW7_1	0.1111
p.V610L	OVKATE	ovary	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	0.1111
p.A592P	ACH-000806	Lymphoma	CCLE	VTATPVLS	DEG_SCF_FBW7_1	0.25
p.A592P	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	VTATPVLS	DEG_SCF_FBW7_1	0.25
p.N593S	ACH-001131	Skin Cancer	CCLE	VTATPVLS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_SCF_FBW7_1	595:602	VTATPVLS	FBXW7	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTATPVLS

Degron related mutations and impact score

Drug responses associated with PPP1R12B mutations

All proteins holding degron of VTATPVLS