DegronMD

Uniprot ID: O14974

Source protein: Protein phosphatase 1 regulatory subunit 12A

Source gene: PPP1R12A

Class: DEG_APCC_KENBOX_2

Location: 815:819

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.698

ASA_SCORE: 96.78

COIL: 0.4248

CONS_SCORE: 0.3535

DSS_SCORE: 0.5531

HELIX: 0.5702

FCONS_SCORE: 0.9697

RIG_SCORE: 0.6578

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T807I	TCGA-55-8511	LUAD	TCGA	TKENE	DEG_APCC_KENBOX_2	0.1111
p.T807I	DO24940	LUAD	ICGC	TKENE	DEG_APCC_KENBOX_2	0.1111
p.I814L	TCGA-77-7463	LUSC	TCGA	TKENE	DEG_APCC_KENBOX_2	0.3056
p.I814L	DO26716	LUSC	ICGC	TKENE	DEG_APCC_KENBOX_2	0.3056
p.T807P	TCGA-CK-4951	COAD	TCGA	TKENE	DEG_APCC_KENBOX_2	0.1111
p.T807P	DO10582	COAD	ICGC	TKENE	DEG_APCC_KENBOX_2	0.1111
p.G813V	DO222750	ESCA	ICGC	TKENE	DEG_APCC_KENBOX_2	0.2778
p.K829E	DO229052	LICA	ICGC	TKENE	DEG_APCC_KENBOX_2	0.1667
p.R820K	SIDM00998	Glioblastoma	GDSC	TKENE	DEG_APCC_KENBOX_2	0.3056
p.R820K	SIDM00391	Plasma Cell Myeloma	GDSC	TKENE	DEG_APCC_KENBOX_2	0.3056
p.R820K	8-MG-BA	central_nervous_system	COSMIC	TKENE	DEG_APCC_KENBOX_2	0.3056
p.R820K	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	TKENE	DEG_APCC_KENBOX_2	0.3056
p.I814T	SIDM00720	Mesothelioma	GDSC	TKENE	DEG_APCC_KENBOX_2	0.3056
p.I814T	SIDM01664	Prostate Carcinoma	GDSC	TKENE	DEG_APCC_KENBOX_2	0.3056
p.R820H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	TKENE	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_APCC_KENBOX_2	815:819	TKENE	APC,CDC20,FZR1	0.698	More...
P13591	Neural cell adhesion molecule 1	DEG_APCC_KENBOX_2	851:855	TKENE	APC,CDC20,FZR1	0.7019	More...
Q9Y5Z4	Heme-binding protein 2	DEG_APCC_KENBOX_2	201:205	TKENE	APC,CDC20,FZR1	0.5191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons