DegronMD

Uniprot ID: Q9Y5Z4

Source protein: Heme-binding protein 2

Source gene: HEBP2

Class: DEG_APCC_KENBOX_2

Location: 201:205

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5191

ASA_SCORE: 133.38

COIL: 0.9456

CONS_SCORE: 0.3961

DSS_SCORE: 0.8448

HELIX: 0.0408

FCONS_SCORE: 0.6335

RIG_SCORE: 0.704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E205K	TCGA-A5-A0G2	UCEC	TCGA	TKENE	DEG_APCC_KENBOX_2	0.591
p.E205K	DO41235	UCEC	ICGC	TKENE	DEG_APCC_KENBOX_2	0.591
p.Q196P	TCGA-CN-6988	HNSC	TCGA	TKENE	DEG_APCC_KENBOX_2	0.1944
p.Q196P	DO14208	HNSC	ICGC	TKENE	DEG_APCC_KENBOX_2	0.1944
p.Q196K	TCGA-KQ-A41N	BLCA	TCGA	TKENE	DEG_APCC_KENBOX_2	0.1944
p.Q196K	DO223588	BLCA	ICGC	TKENE	DEG_APCC_KENBOX_2	0.1944
p.Q196K	ACH-000649	Kidney Cancer	CCLE	TKENE	DEG_APCC_KENBOX_2	0.1944
p.L194S	DO233854	GACA	ICGC	TKENE	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_APCC_KENBOX_2	815:819	TKENE	APC,CDC20,FZR1	0.698	More...
P13591	Neural cell adhesion molecule 1	DEG_APCC_KENBOX_2	851:855	TKENE	APC,CDC20,FZR1	0.7019	More...
Q9Y5Z4	Heme-binding protein 2	DEG_APCC_KENBOX_2	201:205	TKENE	APC,CDC20,FZR1	0.5191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons