DegronMD - P13591(NCAM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R841Q	TCGA-B5-A0JY	UCEC	TCGA	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation rewiring degron network	0.0556
p.E843K	DO229453	SKCA	ICGC	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation rewiring degron network	0.1111
p.V849I	SIDM00578	Neuroblastoma	GDSC	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation blocking phosphorylation signal	0.7222
p.V849I	NB1	autonomic ganglia	COSMIC	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation blocking phosphorylation signal	0.7222
p.A863V	SIDM00216	Colorectal Carcinoma	GDSC	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation rewiring degron network	0.1111
p.A863V	SNU-175	large intestine	COSMIC	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation rewiring degron network	0.1111
p.E845K	SIDM00947	Glioblastoma	GDSC	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation rewiring degron network	0.1667
p.E845K	DK-MG	central nervous system	COSMIC	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation rewiring degron network	0.1667
p.A848V	ACH-000811	Ovarian Cancer	CCLE	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation rewiring degron network	0.25
p.A848V	SK-OV-3	ovary	COSMIC	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation rewiring degron network	0.25
p.V844I	HCC-44	lung	COSMIC	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation rewiring degron network	0.1389
p.A851E	JIMT-1	breast	COSMIC	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation altering degron motif	0.7701
p.A858V	SK-OV-3	ovary	COSMIC	TKENE	DEG_APCC_KENBOX_2	851:855	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons