DegronMD

Uniprot ID: P13591

Source protein: Neural cell adhesion molecule 1

Source gene: NCAM1

Class: DEG_APCC_KENBOX_2

Location: 851:855

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7019

ASA_SCORE: 120.6

COIL: 0.7916

CONS_SCORE: 0.2773

DSS_SCORE: 0.8803

HELIX: 0.1808

FCONS_SCORE: 0.9651

RIG_SCORE: 0.6863

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R841Q	TCGA-B5-A0JY	UCEC	TCGA	TKENE	DEG_APCC_KENBOX_2	0.0556
p.E843K	DO229453	SKCA	ICGC	TKENE	DEG_APCC_KENBOX_2	0.1111
p.V849I	SIDM00578	Neuroblastoma	GDSC	TKENE	DEG_APCC_KENBOX_2	0.7222
p.V849I	NB1	autonomic_ganglia	COSMIC	TKENE	DEG_APCC_KENBOX_2	0.7222
p.A863V	SIDM00216	Colorectal Carcinoma	GDSC	TKENE	DEG_APCC_KENBOX_2	0.1111
p.A863V	SNU-175	large_intestine	COSMIC	TKENE	DEG_APCC_KENBOX_2	0.1111
p.E845K	SIDM00947	Glioblastoma	GDSC	TKENE	DEG_APCC_KENBOX_2	0.1667
p.E845K	DK-MG	central_nervous_system	COSMIC	TKENE	DEG_APCC_KENBOX_2	0.1667
p.A848V	ACH-000811	Ovarian Cancer	CCLE	TKENE	DEG_APCC_KENBOX_2	0.25
p.A848V	SK-OV-3	ovary	COSMIC	TKENE	DEG_APCC_KENBOX_2	0.25
p.V844I	HCC-44	lung	COSMIC	TKENE	DEG_APCC_KENBOX_2	0.1389
p.A851E	JIMT-1	breast	COSMIC	TKENE	DEG_APCC_KENBOX_2	0.7701
p.A858V	SK-OV-3	ovary	COSMIC	TKENE	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_APCC_KENBOX_2	815:819	TKENE	APC,CDC20,FZR1	0.698	More...
P13591	Neural cell adhesion molecule 1	DEG_APCC_KENBOX_2	851:855	TKENE	APC,CDC20,FZR1	0.7019	More...
Q9Y5Z4	Heme-binding protein 2	DEG_APCC_KENBOX_2	201:205	TKENE	APC,CDC20,FZR1	0.5191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons