DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
AASTT
Uniprot ID:
O14974
Source protein:
Protein phosphatase 1 regulatory subunit 12A
Source gene:
PPP1R12A
Class:
DEG_SPOP_SBC_1
Location:
642:646
E3 ligase:
SPOP
DEGRON score:
0.9917
ASA_SCORE:
84.82
COIL:
0.9084
CONS_SCORE:
0.3682
DSS_SCORE:
0.468
HELIX:
0.0772
FCONS_SCORE:
1.1494
RIG_SCORE:
0.7573
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T646R
TCGA-59-2351
OV
TCGA
AASTT
DEG_SPOP_SBC_1
0.7876
p.T646R
DO31240
OV
ICGC
AASTT
DEG_SPOP_SBC_1
0.7876
p.R638T
DO6254
CESC
ICGC
AASTT
DEG_SPOP_SBC_1
0.2222
p.T650K
DO229036
LICA
ICGC
AASTT
DEG_SPOP_SBC_1
0.2222
p.Q649K
DO229041
LICA
ICGC
AASTT
DEG_SPOP_SBC_1
0.25
p.R633T
D-423MG
central_nervous_system
COSMIC
AASTT
DEG_SPOP_SBC_1
0.0833
Drug responses associated with PPP1R12A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AASTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8K4G0
CMRF35-like molecule 7
DEG_SPOP_SBC_1
126:130
AASTT
SPOP
0.5335
More...
O00592
Podocalyxin
DEG_SPOP_SBC_1
320:324
AASTT
SPOP
0.9973
More...
O14974
Protein phosphatase 1 regulatory subunit 12A
DEG_SPOP_SBC_1
642:646
AASTT
SPOP
0.9917
More...
P28356
Homeobox protein Hox-D9
DEG_SPOP_SBC_1
173:177
AASTT
SPOP
0.9609
More...
P55318
Hepatocyte nuclear factor 3-gamma
DEG_SPOP_SBC_1
237:241
AASTT
SPOP
0.7405
More...
Q02086
Transcription factor Sp2
DEG_SPOP_SBC_1
23:27
AASTT
SPOP
0.9884
More...
Q5JR59
Microtubule-associated tumor suppressor candidate 2
DEG_SPOP_SBC_1
959:963
AASTT
SPOP
0.869
More...
Q6W4X9
Mucin-6
DEG_SPOP_SBC_1
2203:2207
AASTT
SPOP
0.7885
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
1974:1978
AASTT
SPOP
0.5287
More...
Q7Z6Z7
E3 ubiquitin-protein ligase HUWE1
DEG_SPOP_SBC_1
1087:1091
AASTT
SPOP
0.5559
More...
Q7Z6Z7
E3 ubiquitin-protein ligase HUWE1
DEG_SPOP_SBC_1
3497:3501
AASTT
SPOP
0.9452
More...
Q7Z6Z7
E3 ubiquitin-protein ligase HUWE1
DEG_SPOP_SBC_1
3529:3533
AASTT
SPOP
0.6297
More...
Q96DR8
Mucin-like protein 1
DEG_SPOP_SBC_1
64:68
AASTT
SPOP
0.9933
More...
Q9Y4G6
Talin-2
DEG_SPOP_SBC_1
1141:1145
AASTT
SPOP
0.6347
More...
Q504T8
Midnolin
DEG_SPOP_SBC_1
225:229
AASTT
SPOP
0.9923
More...
Q53QW1
Testis-expressed protein 44
DEG_SPOP_SBC_1
186:190
AASTT
SPOP
0.8941
More...
Q6UXI7
Vitrin
DEG_SPOP_SBC_1
207:211
AASTT
SPOP
0.5243
More...
Q8WUT4
Leucine-rich repeat neuronal protein 4
DEG_SPOP_SBC_1
449:453
AASTT
SPOP
0.9591
More...
E2RYF6
Mucin-22
DEG_SPOP_SBC_1
418:422
AASTT
SPOP
0.9307
More...
E2RYF6
Mucin-22
DEG_SPOP_SBC_1
537:541
AASTT
SPOP
0.7877
More...
E2RYF6
Mucin-22
DEG_SPOP_SBC_1
1527:1531
AASTT
SPOP
0.6149
More...
Q9NRJ2
Putative uncharacterized protein GSN-AS1
DEG_SPOP_SBC_1
133:137
AASTT
SPOP
0.9628
More...