DegronMD - Q02086(SP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P351H	TCGA-AP-A051	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	356:362	Mutation rewiring degron network	0.1944
p.P351H	DO42673	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	356:362	Mutation rewiring degron network	0.1944
p.K180N	TCGA-AP-A059	UCEC	TCGA	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation substituting flanking lysine	0.2222
p.K180N	DO41361	UCEC	ICGC	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation substituting flanking lysine	0.2222
p.R357C	TCGA-AP-A059	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	356:362	Mutation altering degron motif	0.719
p.R357C	DO41361	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	356:362	Mutation altering degron motif	0.719
p.R357H	TCGA-AP-A0LM	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	356:362	Mutation altering degron motif	0.7133
p.R357H	DO229259	THCA	ICGC	IRTPSGE	DEG_SCF_FBW7_2	356:362	Mutation altering degron motif	0.7133
p.R357H	DO43306	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	356:362	Mutation altering degron motif	0.7133
p.V366I	TCGA-BF-AAOU	SKCM	TCGA	IRTPSGE	DEG_SCF_FBW7_2	356:362	Mutation rewiring degron network	0.2222
p.V366I	DO219460	SKCM	ICGC	IRTPSGE	DEG_SCF_FBW7_2	356:362	Mutation rewiring degron network	0.2222
p.P176H	TCGA-CD-A4MI	STAD	TCGA	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.2222
p.P176H	DO47717	STAD	ICGC	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.2222
p.V177I	TCGA-CK-4951	COAD	TCGA	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.1944
p.V177I	DO10582	COAD	ICGC	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.1944
p.P349L	TCGA-XK-AAIW	PRAD	TCGA	IRTPSGE	DEG_SCF_FBW7_2	356:362	Mutation rewiring degron network	0.1389
p.P349L	DO51407	PRAD	ICGC	IRTPSGE	DEG_SCF_FBW7_2	356:362	Mutation rewiring degron network	0.1389
p.P181S	DO233882	GACA	ICGC	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.0833
p.N163K	SIDM00586	Hepatocellular Carcinoma	GDSC	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.25
p.N163K	ACH-000475	Liver Cancer	CCLE	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.25
p.N163K	huH-1	liver	COSMIC	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.25
p.I158N	SIDM00850	Gastric Carcinoma	GDSC	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.1111
p.I158N	ACH-000880	Gastric Cancer	CCLE	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.1111
p.I158N	AGS	stomach	COSMIC	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.1111
p.N156K	huH-1	liver	COSMIC	IITPSPS	DEG_SCF_FBW7_1	166:172	Mutation rewiring degron network	0.0556

Kaplan plot for SP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SP2

UniProt ID: Q02086

Entrez ID: 6668

Protein name: Transcription factor Sp2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SP2 in