DegronMD

Uniprot ID: Q02086

Source protein: Transcription factor Sp2

Source gene: SP2

Class: DEG_SCF_FBW7_2

Location: 356:362

E3 ligase: FBXW7

DEGRON score: 0.868

ASA_SCORE: 75.7429

COIL: 0.6377

CONS_SCORE: 0.4511

DSS_SCORE: 0.5017

HELIX: 0.0231

FCONS_SCORE: 1.1235

RIG_SCORE: 0.7225

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P351H	TCGA-AP-A051	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.1944
p.P351H	DO42673	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.1944
p.R357C	TCGA-AP-A059	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.719
p.R357C	DO41361	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.719
p.R357H	TCGA-AP-A0LM	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.7133
p.R357H	DO229259	THCA	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.7133
p.R357H	DO43306	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.7133
p.V366I	TCGA-BF-AAOU	SKCM	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.2222
p.V366I	DO219460	SKCM	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.2222
p.P349L	TCGA-XK-AAIW	PRAD	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.1389
p.P349L	DO51407	PRAD	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons