DegronMD - Q9UNN5(FAF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S582I	TCGA-17-Z031	LUAD	TCGA	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation altering degron motif	0.7341
p.S70T	TCGA-55-7726	LUAD	TCGA	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.1944
p.S70T	DO25594	LUAD	ICGC	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.1944
p.S82L	TCGA-85-8664	LUSC	TCGA	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.25
p.S82L	DO45469	LUSC	ICGC	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.25
p.R588W	TCGA-A5-A0G2	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.2222
p.R588W	DO41235	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.2222
p.R577W	TCGA-A5-A1OF	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.3056
p.R577W	DO42568	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.3056
p.F585L	TCGA-D1-A16X	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.3056
p.F585L	DO229008	LICA	ICGC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.3056
p.F585L	DO41799	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.3056
p.P581S	TCGA-DX-AB2E	SARC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation altering degron motif	0.6752
p.P581S	DO220073	SARC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation altering degron motif	0.6752
p.R85Q	TCGA-EJ-7783	PRAD	TCGA	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.1667
p.R85Q	DO36362	PRAD	ICGC	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.1667
p.S582N	TCGA-EO-A22U	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation altering degron motif	0.7069
p.S582N	DO43755	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation altering degron motif	0.7069
p.A592V	TCGA-HU-A4GN	STAD	TCGA	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.1111
p.A592V	DO47833	STAD	ICGC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.1111
p.R589C	DO233885	GACA	ICGC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.1944
p.R85P	DO229346	LAML	ICGC	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.1667
p.R85P	SIDM00556	Neuroblastoma	GDSC	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.1667
p.R85P	KP-N-YN	autonomic ganglia	COSMIC	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.1667
p.T580N	DO229025	LICA	ICGC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation altering degron motif	0.8166
p.R589S	DO229031	LICA	ICGC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.1944
p.P89S	SIDM00053	Pancreatic Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.0556
p.P89S	ACH-001850	Gallbladder Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.0556
p.P89S	ACH-002164	Pancreatic Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.0556
p.P89S	MZ1-PC	pancreas	COSMIC	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.0556
p.A570V	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.1111
p.A570V	ACH-000777	Esophageal Cancer	CCLE	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.1111
p.A570T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.1111
p.A570T	ACH-000777	Esophageal Cancer	CCLE	IRTPSGE	DEG_SCF_FBW7_2	578:584	Mutation rewiring degron network	0.1111
p.P81S	MZ1-PC	pancreas	COSMIC	APTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2778
p.R77P	KP-N-YN	autonomic ganglia	COSMIC	APTSS	DEG_SPOP_SBC_1	75:79	Mutation altering degron motif	0.7512

Kaplan plot for FAF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAF1

UniProt ID: Q9UNN5

Entrez ID: 11124

Protein name: FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAF1 in