DegronMD

Uniprot ID: Q9UNN5

Source protein: FAS-associated factor 1

Source gene: FAF1

Class: DEG_SCF_FBW7_2

Location: 578:584

E3 ligase: FBXW7

DEGRON score: 0.9581

ASA_SCORE: 60.0714

COIL: 0.702

CONS_SCORE: 0.6453

DSS_SCORE: 0.2829

HELIX: 0.003

FCONS_SCORE: 1.2994

RIG_SCORE: 0.7435

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S582I	TCGA-17-Z031	LUAD	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.7341
p.R588W	TCGA-A5-A0G2	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.2222
p.R588W	DO41235	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.2222
p.R577W	TCGA-A5-A1OF	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.3056
p.R577W	DO42568	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.3056
p.F585L	TCGA-D1-A16X	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.3056
p.F585L	DO229008	LICA	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.3056
p.F585L	DO41799	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.3056
p.P581S	TCGA-DX-AB2E	SARC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.6752
p.P581S	DO220073	SARC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.6752
p.S582N	TCGA-EO-A22U	UCEC	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.7069
p.S582N	DO43755	UCEC	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.7069
p.A592V	TCGA-HU-A4GN	STAD	TCGA	IRTPSGE	DEG_SCF_FBW7_2	0.1111
p.A592V	DO47833	STAD	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.1111
p.R589C	DO233885	GACA	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.1944
p.T580N	DO229025	LICA	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.8166
p.R589S	DO229031	LICA	ICGC	IRTPSGE	DEG_SCF_FBW7_2	0.1944
p.A570V	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	IRTPSGE	DEG_SCF_FBW7_2	0.1111
p.A570V	ACH-000777	Esophageal Cancer	CCLE	IRTPSGE	DEG_SCF_FBW7_2	0.1111
p.A570T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	IRTPSGE	DEG_SCF_FBW7_2	0.1111
p.A570T	ACH-000777	Esophageal Cancer	CCLE	IRTPSGE	DEG_SCF_FBW7_2	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons