DegronMD

Uniprot ID: Q02086

Source protein: Transcription factor Sp2

Source gene: SP2

Class: DEG_SCF_FBW7_1

Location: 166:172

E3 ligase: FBXW7

DEGRON score: 0.9504

ASA_SCORE: 65.5143

COIL: 0.6751

CONS_SCORE: 0.3383

DSS_SCORE: 0.615

HELIX: 0.012

FCONS_SCORE: 0.7679

RIG_SCORE: 0.6374

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K180N	TCGA-AP-A059	UCEC	TCGA	IITPSPS	DEG_SCF_FBW7_1	0.2222
p.K180N	DO41361	UCEC	ICGC	IITPSPS	DEG_SCF_FBW7_1	0.2222
p.P176H	TCGA-CD-A4MI	STAD	TCGA	IITPSPS	DEG_SCF_FBW7_1	0.2222
p.P176H	DO47717	STAD	ICGC	IITPSPS	DEG_SCF_FBW7_1	0.2222
p.V177I	TCGA-CK-4951	COAD	TCGA	IITPSPS	DEG_SCF_FBW7_1	0.1944
p.V177I	DO10582	COAD	ICGC	IITPSPS	DEG_SCF_FBW7_1	0.1944
p.P181S	DO233882	GACA	ICGC	IITPSPS	DEG_SCF_FBW7_1	0.0833
p.N163K	SIDM00586	Hepatocellular Carcinoma	GDSC	IITPSPS	DEG_SCF_FBW7_1	0.25
p.N163K	ACH-000475	Liver Cancer	CCLE	IITPSPS	DEG_SCF_FBW7_1	0.25
p.N163K	huH-1	liver	COSMIC	IITPSPS	DEG_SCF_FBW7_1	0.25
p.I158N	SIDM00850	Gastric Carcinoma	GDSC	IITPSPS	DEG_SCF_FBW7_1	0.1111
p.I158N	ACH-000880	Gastric Cancer	CCLE	IITPSPS	DEG_SCF_FBW7_1	0.1111
p.I158N	AGS	stomach	COSMIC	IITPSPS	DEG_SCF_FBW7_1	0.1111
p.N156K	huH-1	liver	COSMIC	IITPSPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02086	Transcription factor Sp2	DEG_SCF_FBW7_1	166:172	IITPSPS	FBXW7	0.9504	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons