DegronMD

Uniprot ID: P55318

Source protein: Hepatocyte nuclear factor 3-gamma

Source gene: FOXA3

Class: DEG_SPOP_SBC_1

Location: 237:241

E3 ligase: SPOP

DEGRON score: 0.7405

ASA_SCORE: 81.26

COIL: 0.8674

CONS_SCORE: 0.3237

DSS_SCORE: 0.7188

HELIX: 0.098

FCONS_SCORE: 0.8674

RIG_SCORE: 0.5853

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T242P	DO218914	SKCA	ICGC	AASTT	DEG_SPOP_SBC_1	0.3056
p.G235R	TCGA-XK-AAIW	PRAD	TCGA	AASTT	DEG_SPOP_SBC_1	0.2778
p.G235R	DO51407	PRAD	ICGC	AASTT	DEG_SPOP_SBC_1	0.2778
p.G235V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	0.2778
p.G235V	ACH-000951	Lung Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	0.2778
p.A244T	TCGA-GS-A9TT	DLBC	TCGA	AASTT	DEG_SPOP_SBC_1	0.25
p.A244T	DO219912	DLBC	ICGC	AASTT	DEG_SPOP_SBC_1	0.25
p.A244T	ACH-001719	Ovarian Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	0.25
p.G233R	TCGA-AA-3821	COAD	TCGA	AASTT	DEG_SPOP_SBC_1	0.2222
p.G233R	DO9314	COAD	ICGC	AASTT	DEG_SPOP_SBC_1	0.2222
p.A245T	SIDM02035	Colorectal Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	0.2222
p.N232S	DO222644	MELA	ICGC	AASTT	DEG_SPOP_SBC_1	0.1944
p.T248N	SIDM00431	T-Lymphoblastic Leukemia	GDSC	AASTT	DEG_SPOP_SBC_1	0.1389
p.T248N	SIDM00736	Non-Cancerous	GDSC	AASTT	DEG_SPOP_SBC_1	0.1389
p.T248N	SIDM00720	Mesothelioma	GDSC	AASTT	DEG_SPOP_SBC_1	0.1389
p.P250L	DO233766	GACA	ICGC	AASTT	DEG_SPOP_SBC_1	0.0833

Showing 1 to 16 of 16 entries

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Drug responses associated with FOXA3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AASTT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8K4G0	CMRF35-like molecule 7	DEG_SPOP_SBC_1	126:130	AASTT	SPOP	0.5335	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	1087:1091	AASTT	SPOP	0.5559	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3497:3501	AASTT	SPOP	0.9452	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3529:3533	AASTT	SPOP	0.6297	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	237:241	AASTT	SPOP	0.7405	More...
P28356	Homeobox protein Hox-D9	DEG_SPOP_SBC_1	173:177	AASTT	SPOP	0.9609	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	449:453	AASTT	SPOP	0.9591	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	959:963	AASTT	SPOP	0.869	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	225:229	AASTT	SPOP	0.9923	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1974:1978	AASTT	SPOP	0.5287	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	418:422	AASTT	SPOP	0.9307	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	537:541	AASTT	SPOP	0.7877	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1527:1531	AASTT	SPOP	0.6149	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2203:2207	AASTT	SPOP	0.7885	More...
Q96DR8	Mucin-like protein 1	DEG_SPOP_SBC_1	64:68	AASTT	SPOP	0.9933	More...
O00592	Podocalyxin	DEG_SPOP_SBC_1	320:324	AASTT	SPOP	0.9973	More...
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	642:646	AASTT	SPOP	0.9917	More...
Q9NRJ2	Putative uncharacterized protein GSN-AS1	DEG_SPOP_SBC_1	133:137	AASTT	SPOP	0.9628	More...
Q9Y4G6	Talin-2	DEG_SPOP_SBC_1	1141:1145	AASTT	SPOP	0.6347	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	186:190	AASTT	SPOP	0.8941	More...
Q02086	Transcription factor Sp2	DEG_SPOP_SBC_1	23:27	AASTT	SPOP	0.9884	More...
Q6UXI7	Vitrin	DEG_SPOP_SBC_1	207:211	AASTT	SPOP	0.5243	More...

Showing 1 to 22 of 22 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASTT

Degron related mutations and impact score

Drug responses associated with FOXA3 mutations

All proteins holding degron of AASTT