DegronMD

Uniprot ID: Q7Z6Z7

Source protein: E3 ubiquitin-protein ligase HUWE1

Source gene: HUWE1

Class: DEG_SPOP_SBC_1

Location: 3497:3501

E3 ligase: SPOP

DEGRON score: 0.9452

ASA_SCORE: 92.12

COIL: 0.941

CONS_SCORE: 0.3706

DSS_SCORE: 0.6564

HELIX: 0.0544

FCONS_SCORE: 1.1297

RIG_SCORE: 0.6584

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3501M	TCGA-BR-8487	STAD	TCGA	AASTT	DEG_SPOP_SBC_1	0.7423
p.T3501M	DO47867	STAD	ICGC	AASTT	DEG_SPOP_SBC_1	0.7423
p.S3491Y	TCGA-EY-A215	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	0.1667
p.S3491Y	TCGA-ND-A4WC	UCS	TCGA	AASTT	DEG_SPOP_SBC_1	0.1667
p.S3491Y	DO42665	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	0.1667
p.T3506I	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	0.1944
p.T3506I	SIDM01622	Breast Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	0.1944
p.T3506I	ACH-000647	Esophageal Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	0.1944
p.T3506I	ACH-000721	Breast Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	0.1944
p.T3506I	TE-1	oesophagus	COSMIC	AASTT	DEG_SPOP_SBC_1	0.1944
p.P3501L	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	AASTT	DEG_SPOP_SBC_1	0.7582
p.T3497I	TE-1	oesophagus	COSMIC	AASTT	DEG_SPOP_SBC_1	0.7078
p.A3505V	NCI-H630	large_intestine	COSMIC	AASTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8K4G0	CMRF35-like molecule 7	DEG_SPOP_SBC_1	126:130	AASTT	SPOP	0.5335	More...
O00592	Podocalyxin	DEG_SPOP_SBC_1	320:324	AASTT	SPOP	0.9973	More...
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	642:646	AASTT	SPOP	0.9917	More...
P28356	Homeobox protein Hox-D9	DEG_SPOP_SBC_1	173:177	AASTT	SPOP	0.9609	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	237:241	AASTT	SPOP	0.7405	More...
Q02086	Transcription factor Sp2	DEG_SPOP_SBC_1	23:27	AASTT	SPOP	0.9884	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	959:963	AASTT	SPOP	0.869	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2203:2207	AASTT	SPOP	0.7885	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1974:1978	AASTT	SPOP	0.5287	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	1087:1091	AASTT	SPOP	0.5559	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3497:3501	AASTT	SPOP	0.9452	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3529:3533	AASTT	SPOP	0.6297	More...
Q96DR8	Mucin-like protein 1	DEG_SPOP_SBC_1	64:68	AASTT	SPOP	0.9933	More...
Q9Y4G6	Talin-2	DEG_SPOP_SBC_1	1141:1145	AASTT	SPOP	0.6347	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	225:229	AASTT	SPOP	0.9923	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	186:190	AASTT	SPOP	0.8941	More...
Q6UXI7	Vitrin	DEG_SPOP_SBC_1	207:211	AASTT	SPOP	0.5243	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	449:453	AASTT	SPOP	0.9591	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	418:422	AASTT	SPOP	0.9307	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	537:541	AASTT	SPOP	0.7877	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1527:1531	AASTT	SPOP	0.6149	More...
Q9NRJ2	Putative uncharacterized protein GSN-AS1	DEG_SPOP_SBC_1	133:137	AASTT	SPOP	0.9628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASTT

Degron related mutations and impact score

Drug responses associated with HUWE1 mutations

All proteins holding degron of AASTT