DegronMD - Q6UXI7(VIT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P201L	TCGA-19-1388	GBM	TCGA	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1667
p.P201L	DO13797	GBM	ICGC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1667
p.S206F	TCGA-4Z-AA7M	BLCA	TCGA	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.3056
p.S206F	DO218976	BLCA	ICGC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.3056
p.V219E	TCGA-50-5049	LUAD	TCGA	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1111
p.V219E	DO23705	LUAD	ICGC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1111
p.R202S	TCGA-A5-A2K5	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1944
p.R202S	DO41379	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1944
p.T211I	TCGA-AN-A04D	BRCA	TCGA	AASTT	DEG_SPOP_SBC_1	207:211	Mutation altering degron motif	0.7078
p.T211I	DO2222	BRCA	ICGC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation altering degron motif	0.7078
p.P205H	TCGA-ER-A19B	SKCM	TCGA	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.2778
p.P205H	DO47491	SKCM	ICGC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.2778
p.S209Y	TCGA-F5-6814	READ	TCGA	AASTT	DEG_SPOP_SBC_1	207:211	Mutation altering degron motif	0.712
p.S209Y	DO36556	READ	ICGC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation altering degron motif	0.712
p.G220C	DO229019	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.0833
p.P216T	SIDM00445	Esophageal Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1944
p.L198V	SIDM00999	Bladder Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.0833
p.L198V	639-V	urinary tract	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.0833
p.S201R	ACH-000766	Lung Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1667
p.S201R	NCI-H1648	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1667
p.Y208H	C-33-A	cervix	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation altering degron motif	0.7229
p.G204V	NCI-H23	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.25
p.E211K	23132-87	stomach	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation altering degron motif	0.7022
p.E211K	IGR-1	skin	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation altering degron motif	0.7022
p.T201R	NCI-H1793	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1667
p.R202C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1944
p.R202C	COR-L311	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1944
p.D200Y	HARA	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1389
p.D198N	SW684	soft tissue	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.0833
p.T201K	Hs746T	stomach	COSMIC	AASTT	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1667

Kaplan plot for VIT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VIT

UniProt ID: Q6UXI7

Entrez ID: 5212

Protein name: Vitrin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VIT in