DegronMD

Uniprot ID: Q6UXI7

Source protein: Vitrin

Source gene: VIT

Class: DEG_SPOP_SBC_1

Location: 207:211

E3 ligase: SPOP

DEGRON score: 0.5243

ASA_SCORE: 56.98

COIL: 0.722

CONS_SCORE: 0.476

DSS_SCORE: 0.6973

HELIX: 0.212

FCONS_SCORE: 0.9856

RIG_SCORE: 0.6282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P201L	TCGA-19-1388	GBM	TCGA	AASTT	DEG_SPOP_SBC_1	0.1667
p.P201L	DO13797	GBM	ICGC	AASTT	DEG_SPOP_SBC_1	0.1667
p.S206F	TCGA-4Z-AA7M	BLCA	TCGA	AASTT	DEG_SPOP_SBC_1	0.3056
p.S206F	DO218976	BLCA	ICGC	AASTT	DEG_SPOP_SBC_1	0.3056
p.V219E	TCGA-50-5049	LUAD	TCGA	AASTT	DEG_SPOP_SBC_1	0.1111
p.V219E	DO23705	LUAD	ICGC	AASTT	DEG_SPOP_SBC_1	0.1111
p.R202S	TCGA-A5-A2K5	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	0.1944
p.R202S	DO41379	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	0.1944
p.T211I	TCGA-AN-A04D	BRCA	TCGA	AASTT	DEG_SPOP_SBC_1	0.7078
p.T211I	DO2222	BRCA	ICGC	AASTT	DEG_SPOP_SBC_1	0.7078
p.P205H	TCGA-ER-A19B	SKCM	TCGA	AASTT	DEG_SPOP_SBC_1	0.2778
p.P205H	DO47491	SKCM	ICGC	AASTT	DEG_SPOP_SBC_1	0.2778
p.S209Y	TCGA-F5-6814	READ	TCGA	AASTT	DEG_SPOP_SBC_1	0.712
p.S209Y	DO36556	READ	ICGC	AASTT	DEG_SPOP_SBC_1	0.712
p.G220C	DO229019	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	0.0833
p.P216T	SIDM00445	Esophageal Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	0.1944
p.L198V	SIDM00999	Bladder Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	0.0833
p.L198V	639-V	urinary_tract	COSMIC	AASTT	DEG_SPOP_SBC_1	0.0833
p.S201R	ACH-000766	Lung Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	0.1667
p.S201R	NCI-H1648	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	0.1667
p.Y208H	C-33-A	cervix	COSMIC	AASTT	DEG_SPOP_SBC_1	0.7229
p.G204V	NCI-H23	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	0.25
p.E211K	23132-87	stomach	COSMIC	AASTT	DEG_SPOP_SBC_1	0.7022
p.E211K	IGR-1	skin	COSMIC	AASTT	DEG_SPOP_SBC_1	0.7022
p.T201R	NCI-H1793	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	0.1667
p.R202C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	AASTT	DEG_SPOP_SBC_1	0.1944
p.R202C	COR-L311	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	0.1944
p.D200Y	HARA	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	0.1389
p.D198N	SW684	soft_tissue	COSMIC	AASTT	DEG_SPOP_SBC_1	0.0833
p.T201K	Hs746T	stomach	COSMIC	AASTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8K4G0	CMRF35-like molecule 7	DEG_SPOP_SBC_1	126:130	AASTT	SPOP	0.5335	More...
O00592	Podocalyxin	DEG_SPOP_SBC_1	320:324	AASTT	SPOP	0.9973	More...
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	642:646	AASTT	SPOP	0.9917	More...
P28356	Homeobox protein Hox-D9	DEG_SPOP_SBC_1	173:177	AASTT	SPOP	0.9609	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	237:241	AASTT	SPOP	0.7405	More...
Q02086	Transcription factor Sp2	DEG_SPOP_SBC_1	23:27	AASTT	SPOP	0.9884	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	959:963	AASTT	SPOP	0.869	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2203:2207	AASTT	SPOP	0.7885	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1974:1978	AASTT	SPOP	0.5287	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	1087:1091	AASTT	SPOP	0.5559	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3497:3501	AASTT	SPOP	0.9452	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3529:3533	AASTT	SPOP	0.6297	More...
Q96DR8	Mucin-like protein 1	DEG_SPOP_SBC_1	64:68	AASTT	SPOP	0.9933	More...
Q9Y4G6	Talin-2	DEG_SPOP_SBC_1	1141:1145	AASTT	SPOP	0.6347	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	225:229	AASTT	SPOP	0.9923	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	186:190	AASTT	SPOP	0.8941	More...
Q6UXI7	Vitrin	DEG_SPOP_SBC_1	207:211	AASTT	SPOP	0.5243	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	449:453	AASTT	SPOP	0.9591	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	418:422	AASTT	SPOP	0.9307	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	537:541	AASTT	SPOP	0.7877	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1527:1531	AASTT	SPOP	0.6149	More...
Q9NRJ2	Putative uncharacterized protein GSN-AS1	DEG_SPOP_SBC_1	133:137	AASTT	SPOP	0.9628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASTT

Degron related mutations and impact score

Drug responses associated with VIT mutations

All proteins holding degron of AASTT