DegronMD - Q7Z6Z7(HUWE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S2184N	TCGA-04-1356	OV	TCGA	PSTSS	DEG_SPOP_SBC_1	2191:2195	Mutation rewiring degron network	0.1389
p.S2184N	DO29568	OV	ICGC	PSTSS	DEG_SPOP_SBC_1	2191:2195	Mutation rewiring degron network	0.1389
p.A3516S	TCGA-05-4382	LUAD	TCGA	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.25
p.A3516S	DO24900	LUAD	ICGC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.25
p.G3477V	TCGA-19-1386	GBM	TCGA	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation rewiring degron network	0.25
p.G3477V	TCGA-19-1386	GBM	TCGA	ATSTT	DEG_SPOP_SBC_1	3486:3490	Mutation rewiring degron network	0.0833
p.G3477V	DO10902	GBM	ICGC	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation rewiring degron network	0.25
p.G3477V	DO10902	GBM	ICGC	ATSTT	DEG_SPOP_SBC_1	3486:3490	Mutation rewiring degron network	0.0833
p.V3528L	TCGA-21-1070	LUSC	TCGA	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.3056
p.V3528L	DO27088	LUSC	ICGC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.3056
p.Q3231K	TCGA-29-1777	OV	TCGA	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.0833
p.Q3231K	DO28071	OV	ICGC	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.0833
p.T3483A	TCGA-33-4532	LUSC	TCGA	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation altering degron motif	0.7139
p.T3483A	DO26626	LUSC	ICGC	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation altering degron motif	0.7139
p.T3532N	TCGA-43-2578	LUSC	TCGA	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation altering degron motif	0.7055
p.T3532N	TCGA-77-8140	LUSC	TCGA	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation altering degron motif	0.7055
p.T3532N	DO26834	LUSC	ICGC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation altering degron motif	0.7055
p.T3532N	DO26662	LUSC	ICGC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation altering degron motif	0.7055
p.D2752H	TCGA-85-A4CL	LUSC	TCGA	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.3056
p.D2752H	DO45454	LUSC	ICGC	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.3056
p.P1096S	TCGA-90-A59Q	LUSC	TCGA	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1944
p.P1096S	DO50103	LUSC	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1944
p.Q2882H	TCGA-97-7938	LUAD	TCGA	AGSST	DEG_SPOP_SBC_1	2885:2889	Mutation rewiring degron network	0.25
p.Q2882H	DO24329	LUAD	ICGC	AGSST	DEG_SPOP_SBC_1	2885:2889	Mutation rewiring degron network	0.25
p.A1088T	TCGA-A5-A0G1	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation altering degron motif	0.6028
p.A1088T	DO42472	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation altering degron motif	0.6028
p.R3232C	TCGA-AJ-A8CW	UCEC	TCGA	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.1111
p.R3232C	TCGA-BR-8296	STAD	TCGA	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.1111
p.R3232C	DO38539	STAD	ICGC	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.1111
p.R3232C	DO52400	UCEC	ICGC	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.1111
p.R3232C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.1111
p.R3232C	ACH-002256	Leukemia	CCLE	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.1111
p.R3232C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.1111
p.V3528I	TCGA-AN-A046	BRCA	TCGA	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.3056
p.V3528I	DO1285	BRCA	ICGC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.3056
p.V3528I	SIDM02015	Colorectal Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.3056
p.S3513F	TCGA-AP-A0LM	UCEC	TCGA	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation altering degron motif	0.7982
p.S3513F	DO43306	UCEC	ICGC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation altering degron motif	0.7982
p.K2759N	TCGA-AP-A0LM	UCEC	TCGA	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation substituting flanking lysine	0.2222
p.K2759N	DO43306	UCEC	ICGC	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation substituting flanking lysine	0.2222
p.A1098V	TCGA-AU-6004	COAD	TCGA	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1389
p.A1098V	DO7780	COAD	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1389
p.P2947L	TCGA-AX-A0J1	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.2778
p.P2947L	DO41199	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.2778
p.P2947L	SIDM00781	Colorectal Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.2778
p.P2947L	SIDM00780	Colorectal Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.2778
p.P2947L	ACH-000967	Colon/Colorectal Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.2778
p.P2947L	ACH-001199	Colon/Colorectal Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.2778
p.P2947L	SNU-C2B	large intestine	COSMIC	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.2778
p.S1707N	TCGA-AX-A2HC	UCEC	TCGA	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation blocking phosphorylation signal	0.5833
p.S1707N	DO41572	UCEC	ICGC	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation blocking phosphorylation signal	0.5833
p.S2593N	TCGA-B5-A11E	UCEC	TCGA	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation blocking phosphorylation signal	0.6389
p.S2593N	DO41644	UCEC	ICGC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation blocking phosphorylation signal	0.6389
p.G1719D	TCGA-B5-A1MR	UCEC	TCGA	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation rewiring degron network	0.3056
p.G1719D	DO41758	UCEC	ICGC	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation rewiring degron network	0.3056
p.P1723L	TCGA-B5-A1MX	UCEC	TCGA	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation rewiring degron network	0.1944
p.P1723L	TCGA-FW-A3R5	SKCM	TCGA	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation rewiring degron network	0.1944
p.P1723L	DO37406	SKCM	ICGC	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation rewiring degron network	0.1944
p.P1723L	DO41999	UCEC	ICGC	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation rewiring degron network	0.1944
p.R2603Q	TCGA-BR-4368	STAD	TCGA	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.6218
p.R2603Q	DO38715	STAD	ICGC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.6218
p.R2605H	TCGA-BR-7707	STAD	TCGA	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.7133
p.R2605H	DO38487	STAD	ICGC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.7133
p.T3501M	TCGA-BR-8487	STAD	TCGA	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation altering degron motif	0.7423
p.T3501M	DO47867	STAD	ICGC	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation altering degron motif	0.7423
p.V3527A	TCGA-BR-8680	STAD	TCGA	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.2778
p.V3527A	DO47769	STAD	ICGC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.2778
p.V1079F	TCGA-BR-A4PD	STAD	TCGA	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1111
p.V1079F	DO47831	STAD	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1111
p.R2941Q	TCGA-C5-A1MK	CESC	TCGA	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.1111
p.R2941Q	DO6290	CESC	ICGC	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.1111
p.R2601W	TCGA-D1-A167	UCEC	TCGA	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.8634
p.R2601W	DO40978	UCEC	ICGC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.8634
p.S3470L	TCGA-D1-A16B	UCEC	TCGA	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation rewiring degron network	0.0556
p.S3470L	DO41722	UCEC	ICGC	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation rewiring degron network	0.0556
p.G2737W	TCGA-D3-A2JN	SKCM	TCGA	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.1111
p.G2737W	TCGA-DA-A1I7	SKCM	TCGA	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.1111
p.G2737W	TCGA-EE-A3AG	SKCM	TCGA	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.1111
p.G2737W	DO37471	SKCM	ICGC	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.1111
p.G2737W	DO37951	SKCM	ICGC	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.1111
p.G2737W	DO47590	SKCM	ICGC	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.1111
p.E3237D	TCGA-DF-A2KU	UCEC	TCGA	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.25
p.E3237D	DO223286	UCEC	ICGC	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.25
p.S3233R	TCGA-DX-A6YV	SARC	TCGA	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.1389
p.S3233R	DO220011	SARC	ICGC	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.1389
p.P2947T	TCGA-DX-A6YV	SARC	TCGA	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.2778
p.P2947T	DO220011	SARC	ICGC	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.2778
p.Q3473R	TCGA-EB-A42Y	SKCM	TCGA	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation rewiring degron network	0.1389
p.Q3473R	DO37691	SKCM	ICGC	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation rewiring degron network	0.1389
p.A2753T	TCGA-EC-A24G	UCEC	TCGA	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.2778
p.A2753T	DO40996	UCEC	ICGC	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.2778
p.P1124L	TCGA-EE-A29L	SKCM	TCGA	PPPY	ITCH	1117:1120	Mutation rewiring degron network	0.2222
p.P1124L	DO222599	MELA	ICGC	PPPY	ITCH	1117:1120	Mutation rewiring degron network	0.2222
p.P1124L	DO37835	SKCM	ICGC	PPPY	ITCH	1117:1120	Mutation rewiring degron network	0.2222
p.P1094Q	TCGA-EE-A2MD	SKCM	TCGA	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.25
p.P1094Q	DO37851	SKCM	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.25
p.T3533K	TCGA-EO-A22R	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation altering degron motif	0.7306
p.T3533K	DO42713	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation altering degron motif	0.7306
p.F1130L	TCGA-EO-A22U	UCEC	TCGA	PPPY	ITCH	1117:1120	Mutation rewiring degron network	0.0556
p.F1130L	DO43755	UCEC	ICGC	PPPY	ITCH	1117:1120	Mutation rewiring degron network	0.0556
p.S3476A	TCGA-EO-A3AY	UCEC	TCGA	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation rewiring degron network	0.2222
p.S3476A	TCGA-EO-A3AY	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	3486:3490	Mutation rewiring degron network	0.0556
p.S3476A	DO43202	UCEC	ICGC	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation rewiring degron network	0.2222
p.S3476A	DO43202	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	3486:3490	Mutation rewiring degron network	0.0556
p.A1725V	TCGA-EY-A1GU	UCEC	TCGA	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation rewiring degron network	0.1389
p.A1725V	DO41518	UCEC	ICGC	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation rewiring degron network	0.1389
p.S3491Y	TCGA-EY-A215	UCEC	TCGA	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation rewiring degron network	0.1389
p.S3491Y	TCGA-EY-A215	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	3486:3490	Mutation rewiring degron network	0.3056
p.S3491Y	TCGA-EY-A215	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation rewiring degron network	0.1667
p.S3491Y	TCGA-ND-A4WC	UCS	TCGA	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation rewiring degron network	0.1389
p.S3491Y	TCGA-ND-A4WC	UCS	TCGA	ATSTT	DEG_SPOP_SBC_1	3486:3490	Mutation rewiring degron network	0.3056
p.S3491Y	TCGA-ND-A4WC	UCS	TCGA	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation rewiring degron network	0.1667
p.S3491Y	DO42665	UCEC	ICGC	ASSTT	DEG_SPOP_SBC_1	3480:3484	Mutation rewiring degron network	0.1389
p.S3491Y	DO42665	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	3486:3490	Mutation rewiring degron network	0.3056
p.S3491Y	DO42665	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation rewiring degron network	0.1667
p.K1713E	TCGA-G4-6302	COAD	TCGA	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation blocking ubiquitination signal	0.75
p.K1713E	DO8778	COAD	ICGC	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation blocking ubiquitination signal	0.75
p.G2737V	TCGA-G7-6797	KIRP	TCGA	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.1111
p.G2737V	DO20917	KIRP	ICGC	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.1111
p.E2881K	TCGA-JW-A5VL	CESC	TCGA	AGSST	DEG_SPOP_SBC_1	2885:2889	Mutation rewiring degron network	0.2222
p.E2881K	DO49976	CESC	ICGC	AGSST	DEG_SPOP_SBC_1	2885:2889	Mutation rewiring degron network	0.2222
p.L2590I	TCGA-KO-8404	KICH	TCGA	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation rewiring degron network	0.1111
p.L2590I	DO220545	KICH	ICGC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation rewiring degron network	0.1111
p.P2739L	TCGA-L9-A444	LUAD	TCGA	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.1667
p.P2739L	DO26015	LUAD	ICGC	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.1667
p.P3515T	TCGA-NA-A4R0	UCS	TCGA	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.2778
p.S3248N	TCGA-VS-A9UY	CESC	TCGA	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.2778
p.S3248N	DO219742	CESC	ICGC	IETPKLT	DEG_SCF_FBW7_1	3240:3246	Mutation rewiring degron network	0.2778
p.T3521A	TCGA-ZP-A9CY	LIHC	TCGA	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.1111
p.T3521A	TCGA-ZP-A9CY	LIHC	TCGA	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.1111
p.T3521A	DO52329	LIHC	ICGC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.1111
p.T3521A	DO52329	LIHC	ICGC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.1111
p.T2889N	DO225319	BRCA	ICGC	AGSST	DEG_SPOP_SBC_1	2885:2889	Mutation altering degron motif	0.8166
p.S1707R	DO1235	BRCA	ICGC	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation blocking phosphorylation signal	0.5833
p.P2895Q	DO223368	CLLE	ICGC	AGSST	DEG_SPOP_SBC_1	2885:2889	Mutation rewiring degron network	0.1667
p.V2613I	DO227549	COCA	ICGC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation rewiring degron network	0.1111
p.D2939H	DO227988	COCA	ICGC	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.0556
p.S1084N	DO222718	COCA	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation blocking phosphorylation signal	0.6944
p.S1084G	DO50398	ESAD	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation blocking phosphorylation signal	0.6944
p.R2603W	DO228732	GACA	ICGC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.7523
p.A1098T	DO233151	GACA	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1389
p.A2202V	DO233088	GACA	ICGC	PSTSS	DEG_SPOP_SBC_1	2191:2195	Mutation rewiring degron network	0.1389
p.R1714H	DO228946	LICA	ICGC	RKENK	DEG_APCC_KENBOX_2	1714:1718	Mutation altering degron motif	0.7133
p.A1093E	DO228948	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.2778
p.P2958L	DO228998	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.1944
p.Q1081K	DO229015	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1667
p.T3541N	DO229029	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.1111
p.H1086N	DO229045	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.3056
p.V3511I	DO229050	LICA	ICGC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation altering degron motif	0.5965
p.A2754D	DO229006	LICA	ICGC	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.25
p.S1084R	DO229009	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation blocking phosphorylation signal	0.6944
p.A1098S	DO50893	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1389
p.I2186V	DO50804	LIRI	ICGC	PSTSS	DEG_SPOP_SBC_1	2191:2195	Mutation rewiring degron network	0.1944
p.S2963C	DO45269	LIRI	ICGC	PSTSS	DEG_SPOP_SBC_1	2949:2953	Mutation rewiring degron network	0.0556
p.S3488T	DO48727	LIRI	ICGC	ATSTT	DEG_SPOP_SBC_1	3486:3490	Mutation altering degron motif	0.6005
p.P3510S	DO220875	MELA	ICGC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation altering degron motif	0.6752
p.T3542A	DO232761	PBCA	ICGC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.0833
p.R1080H	DO229257	THCA	ICGC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.1389
p.P2883L	DO229221	THCA	ICGC	AGSST	DEG_SPOP_SBC_1	2885:2889	Mutation rewiring degron network	0.2778
p.R2605C	DO229234	THCA	ICGC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.719
p.R2605C	SIDM01088	Endometrial Carcinoma	GDSC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.719
p.R2605C	ACH-000965	Endometrial/Uterine Cancer	CCLE	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.719
p.R2605C	ACH-001786	Colon/Colorectal Cancer	CCLE	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.719
p.R2605C	RL95-2	endometrium	COSMIC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation altering degron motif	0.719
p.P3510L	SIDM00689	B-Lymphoblastic Leukemia	GDSC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation altering degron motif	0.7582
p.P3510L	ACH-000151	Leukemia	CCLE	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation altering degron motif	0.7582
p.P3510L	JM1	haematopoietic and lymphoid tissue	COSMIC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation altering degron motif	0.7582
p.T3506I	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.2778
p.T3506I	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation rewiring degron network	0.1944
p.T3506I	SIDM01622	Breast Carcinoma	GDSC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.2778
p.T3506I	SIDM01622	Breast Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation rewiring degron network	0.1944
p.T3506I	ACH-000647	Esophageal Cancer	CCLE	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.2778
p.T3506I	ACH-000647	Esophageal Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation rewiring degron network	0.1944
p.T3506I	ACH-000721	Breast Cancer	CCLE	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.2778
p.T3506I	ACH-000721	Breast Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation rewiring degron network	0.1944
p.T3506I	TE-1	oesophagus	COSMIC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.2778
p.T3506I	TE-1	oesophagus	COSMIC	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation rewiring degron network	0.1944
p.T1129I	SIDM00818	Kidney Carcinoma	GDSC	PPPY	ITCH	1117:1120	Mutation rewiring degron network	0.0833
p.T1129I	ACH-002190	Kidney Cancer	CCLE	PPPY	ITCH	1117:1120	Mutation rewiring degron network	0.0833
p.T1129I	RCC-JF	kidney	COSMIC	PPPY	ITCH	1117:1120	Mutation rewiring degron network	0.0833
p.R1083S	SIDM00772	Breast Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.2222
p.R1083S	ACH-000755	Breast Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.2222
p.R1083S	HCC2218	breast	COSMIC	AASTT	DEG_SPOP_SBC_1	1087:1091	Mutation rewiring degron network	0.2222
p.T3541S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.1111
p.T3541S	ACH-000900	Lung Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.1111
p.T3541S	NCI-H23	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation rewiring degron network	0.1111
p.T1110I	SIDM01394	Kidney Carcinoma	GDSC	PPPY	ITCH	1117:1120	Mutation rewiring degron network	0.1389
p.T1110I	ACH-000907	Kidney Cancer	CCLE	PPPY	ITCH	1117:1120	Mutation rewiring degron network	0.1389
p.A3486T	ACH-000990	Endometrial/Uterine Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	3486:3490	Mutation altering degron motif	0.7139
p.P2895L	ACH-001369	Ovarian Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	2885:2889	Mutation rewiring degron network	0.1667
p.A3514V	ACH-002287	Colon/Colorectal Cancer	CCLE	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.3056
p.A3514V	NCI-H630	large intestine	COSMIC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.3056
p.R2609C	SNU-1040	large intestine	COSMIC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation rewiring degron network	0.2222
p.P3501L	JM1	haematopoietic and lymphoid tissue	COSMIC	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation altering degron motif	0.7582
p.R2596C	RL95-2	endometrium	COSMIC	LQSRGRAR	SCF_FBXL2	2598:2605	Mutation rewiring degron network	0.2778
p.T3497I	TE-1	oesophagus	COSMIC	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation altering degron motif	0.7078
p.R2894S	KLE	endometrium	COSMIC	AGSST	DEG_SPOP_SBC_1	2885:2889	Mutation rewiring degron network	0.1944
p.T1120I	RCC-JF	kidney	COSMIC	PPPY	ITCH	1117:1120	Mutation altering degron motif	0.7078
p.A3505V	NCI-H630	large intestine	COSMIC	PTPVTS	DEG_SCF_FBW7_1	3508:3513	Mutation rewiring degron network	0.25
p.A3505V	NCI-H630	large intestine	COSMIC	AASTT	DEG_SPOP_SBC_1	3497:3501	Mutation rewiring degron network	0.2222
p.T3532S	NCI-H23	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	3529:3533	Mutation altering degron motif	0.6005
p.G2754D	AN3-CA	endometrium	COSMIC	PTTPSST	DEG_SCF_FBW7_1	2745:2751	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HUWE1

UniProt ID: Q7Z6Z7

Entrez ID: 10075

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HUWE1 in