DegronMD

Uniprot ID: Q7Z6Z7

Source protein: E3 ubiquitin-protein ligase HUWE1

Source gene: HUWE1

Class: DEG_SCF_FBW7_1

Location: 3508:3513

E3 ligase: FBXW7

DEGRON score: 0.7023

ASA_SCORE: 86.5

COIL: 0.896

CONS_SCORE: 0.3369

DSS_SCORE: 0.5286

HELIX: 0.0557

FCONS_SCORE: 0.964

RIG_SCORE: 0.7436

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3516S	TCGA-05-4382	LUAD	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.25
p.A3516S	DO24900	LUAD	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.25
p.S3513F	TCGA-AP-A0LM	UCEC	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.7982
p.S3513F	DO43306	UCEC	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.7982
p.P3515T	TCGA-NA-A4R0	UCS	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.2778
p.T3521A	TCGA-ZP-A9CY	LIHC	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.1111
p.T3521A	DO52329	LIHC	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.1111
p.V3511I	DO229050	LICA	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.5965
p.P3510S	DO220875	MELA	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.6752
p.P3510L	SIDM00689	B-Lymphoblastic Leukemia	GDSC	PTPVTS	DEG_SCF_FBW7_1	0.7582
p.P3510L	ACH-000151	Leukemia	CCLE	PTPVTS	DEG_SCF_FBW7_1	0.7582
p.P3510L	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPVTS	DEG_SCF_FBW7_1	0.7582
p.T3506I	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PTPVTS	DEG_SCF_FBW7_1	0.2778
p.T3506I	SIDM01622	Breast Carcinoma	GDSC	PTPVTS	DEG_SCF_FBW7_1	0.2778
p.T3506I	ACH-000647	Esophageal Cancer	CCLE	PTPVTS	DEG_SCF_FBW7_1	0.2778
p.T3506I	ACH-000721	Breast Cancer	CCLE	PTPVTS	DEG_SCF_FBW7_1	0.2778
p.T3506I	TE-1	oesophagus	COSMIC	PTPVTS	DEG_SCF_FBW7_1	0.2778
p.A3514V	ACH-002287	Colon/Colorectal Cancer	CCLE	PTPVTS	DEG_SCF_FBW7_1	0.3056
p.A3514V	NCI-H630	large_intestine	COSMIC	PTPVTS	DEG_SCF_FBW7_1	0.3056
p.A3505V	NCI-H630	large_intestine	COSMIC	PTPVTS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01196	Runt-related transcription factor 1	DEG_SCF_FBW7_1	330:335	PTPVTS	FBXW7	0.9977	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SCF_FBW7_1	908:913	PTPVTS	FBXW7	0.9937	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SCF_FBW7_1	3508:3513	PTPVTS	FBXW7	0.7023	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons